Publication Date:
2014-08-23
Description:
Article The ‘funny’ current ( I f ) is important for the generation and regulation of the heart’s automaticity. Here the authors show that I f silencing through genetic modification of the f -channel component HCN4 causes heart arrhythmia by altering Ca 2+ handling in pacemaker myocytes. Nature Communications doi: 10.1038/ncomms5664 Authors: Pietro Mesirca, Jacqueline Alig, Angelo G. Torrente, Jana Christina Müller, Laurine Marger, Anne Rollin, Claire Marquilly, Anne Vincent, Stefan Dubel, Isabelle Bidaud, Anne Fernandez, Anika Seniuk, Birgit Engeland, Jasmin Singh, Lucile Miquerol, Heimo Ehmke, Thomas Eschenhagen, Joel Nargeot, Kevin Wickman, Dirk Isbrandt, Matteo E. Mangoni
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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