Publication Date:
2015-11-29
Description:
Article How breast cancer cells adapt to individual therapies targeting the oestrogen receptor alpha is poorly understood. Here the authors show resistance emerging through differential epigenetic reprogramming that activates the cholesterol biosynthesis pathway. Nature Communications doi: 10.1038/ncomms10044 Authors: Van T. M. Nguyen, Iros Barozzi, Monica Faronato, Ylenia Lombardo, Jennifer H. Steel, Naina Patel, Philippa Darbre, Leandro Castellano, Balázs Győrffy, Laura Woodley, Alba Meira, Darren K. Patten, Valentina Vircillo, Manikandan Periyasamy, Simak Ali, Gianmaria Frige, Saverio Minucci, R. Charles Coombes, Luca Magnani
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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