Publication Date:
2015-05-24
Description:
Article Chronic myeloid leukaemia is characterized by the genetic translocation t(9;22) encoding for BCR-ABL oncogene; however, the molecular mechanisms of disease progression are poorly understood. Here Amabile et al . show that aberrant methylation is promoted by BCR-ABL, driving the evolution of the disease. Nature Communications doi: 10.1038/ncomms8091 Authors: Giovanni Amabile, Annalisa Di Ruscio, Fabian Müller, Robert S. Welner, Henry Yang, Alexander K. Ebralidze, Hong Zhang, Elena Levantini, Lihua Qi, Giovanni Martinelli, Thijn Brummelkamp, Michelle M. Le Beau, Maria E. Figueroa, Christoph Bock, Daniel G. Tenen
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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