Publication Date:
2015-12-05
Description:
Article Osteosarcomas are a heterogenous group of tumours and little is known about how these tumours evolve. Here, Kovac et al . use exome sequencing and discover that although no driver gene explains the majority of these tumours, they are characterized by specific mutation signatures and genomic instability typical of BRCA1/2-deficient tumours. Nature Communications doi: 10.1038/ncomms9940 Authors: Michal Kovac, Claudia Blattmann, Sebastian Ribi, Jan Smida, Nikola S. Mueller, Florian Engert, Francesc Castro-Giner, Joachim Weischenfeldt, Monika Kovacova, Andreas Krieg, Dimosthenis Andreou, Per-Ulf Tunn, Hans Roland Dürr, Hans Rechl, Klaus-Dieter Schaser, Ingo Melcher, Stefan Burdach, Andreas Kulozik, Katja Specht, Karl Heinimann, Simone Fulda, Stefan Bielack, Gernot Jundt, Ian Tomlinson, Jan O. Korbel, Michaela Nathrath, Daniel Baumhoer
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
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Natural Sciences in General
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Physics
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