Publikationsdatum:
2016-12-11
Beschreibung:
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells Nature Communications, Published online: 9 December 2016; doi:10.1038/ncomms13602 Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic development in vitro but is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak-like priming in hPSCs via secreted LEFTY/CERBERUS.
Digitale ISSN:
2041-1723
Thema:
Biologie
,
Chemie und Pharmazie
,
Allgemeine Naturwissenschaft
,
Physik
Permalink