Publication Date:
2015-03-19
Description:
Article The lipid kinase PI3KC2α is essential for embryogenesis, yet its role in adult homeostasis is unknown. Here, the authors show that PI3KC2α regulates the structure of the internal membrane reserves of murine megakaryocytes and platelets, affecting the platelets’ adhesiveness and prothrombotic function. Nature Communications doi: 10.1038/ncomms7535 Authors: Jessica K. Mountford, Claire Petitjean, Harun W. Kusuma Putra, Jonathan A. McCafferty, Natasha M. Setiabakti, Hannah Lee, Lotte L. Tønnesen, James D. McFadyen, Simone M. Schoenwaelder, Anita Eckly, Christian Gachet, Sarah Ellis, Anne K. Voss, Ross A. Dickins, Justin R. Hamilton, Shaun P. Jackson
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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