Publication Date:
2016-06-30
Description:
A combinatorial strategy for treating KRAS-mutant lung cancer Nature 534, 7609 (2016). doi:10.1038/nature18600 Authors: Eusebio Manchado, Susann Weissmueller, John P. Morris, Chi-Chao Chen, Ramona Wullenkord, Amaia Lujambio, Elisa de Stanchina, John T. Poirier, Justin F. Gainor, Ryan B. Corcoran, Jeffrey A. Engelman, Charles M. Rudin, Neal Rosen & Scott W. Lowe Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of compensatory or parallel pathways that limit their efficacy as
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink