Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉Identification of a conserved chromatin crosstalk, in which histone deacetylases Rpd3/HDAC1 restrict H3K79 methylation, uncovers a DOT1L-dose dependency of thymic lymphoma in HDAC1-deficient mice.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉Yeast histone deacetylase and transcriptional repressor Rpd3 restricts Dot1-mediated histone H3K79 methylation at its target genes.〈/p〉〈/li〉
〈li〉〈p〉The murine Rpd3 homolog HDAC1 negatively regulates DOT1L-mediated H3K79 methylation in thymocytes.〈/p〉〈/li〉
〈li〉〈p〉Murine thymic lymphomas caused by the loss of HDAC1 depend on proper DOT1L dosage.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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