Publication Date:
2015-02-20
Description:
Article Duchenne muscular dystrophy is caused by mutations in the dystrophin gene. Here, Ousterout et al . use multiplexed CRISPR/Cas9 genome editing to excise a large portion of the gene that carries over 60% of known dystrophin mutations. They show that this excision restores dystrophin expression in patient-derived cells. Nature Communications doi: 10.1038/ncomms7244 Authors: David G. Ousterout, Ami M. Kabadi, Pratiksha I. Thakore, William H. Majoros, Timothy E. Reddy, Charles A. Gersbach
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink