Publication Date:
2015-08-06
Description:
Article Dysfunctional redox regulation in cancer can damage dNTPs so inhibiting dNTP pool sanitizing enzymes, such as MTH1, is a potential cancer treatment. Here, Carter et al. characterize MTH2 (NUDT15) and show that it is not a dNTP sanitizer, and so is unlikely to influence the efficacy of MTH1 inhibitors. Nature Communications doi: 10.1038/ncomms8871 Authors: Megan Carter, Ann-Sofie Jemth, Anna Hagenkort, Brent D. G. Page, Robert Gustafsson, Julia J. Griese, Helge Gad, Nicholas C. K. Valerie, Matthieu Desroses, Johan Boström, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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