Publication Date:
2016-11-17
Description:
Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors Nature Communications, Published online: 16 November 2016; doi:10.1038/ncomms13509 Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in microcephaly in mice.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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