Publication Date:
2015-03-29
Description:
Article Most radical SAM enzymes use a [4Fe-4S] cluster to generate a 5′-deoxyadenosyl radical. Here the authors show the radical SAM thiamin pyrimidine synthase ThiC comprises an additional active site metal, probably representing an evolutionary link between the radical SAM and adenosylcobalamin-dependent enzyme superfamilies. Nature Communications doi: 10.1038/ncomms7480 Authors: Michael K. Fenwick, Angad P. Mehta, Yang Zhang, Sameh H. Abdelwahed, Tadhg P. Begley, Steven E. Ealick
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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