Publication Date:
2018-10-26
Description:
Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex, Published online: 25 October 2018; doi:10.1038/s41467-018-06953-0 Oncoprotein E6 facilitates the E6AP-catalyzed ubiquitination of p53. Here, the authors study the structural basis of this process by qualitative and quantitative cross-linking mass spectrometry, providing insights into E6AP-E6-p53 complex assembly and the conformational dynamics that enable p53 ubiquitination.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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