ALBERT

Description: Phosphorylation of the translation initiation factor eIF2α within the mediobasal hypothalamus is known to suppress food intake, but the role of the eIF2α phosphatases in regulating body weight is poorly understood. Mice deficient in active PPP1R15A, a stress-inducible eIF2α phosphatase, are healthy and more resistant to endoplasmic reticulum stress than wild type controls. We report that when female Ppp1r15a mutant mice are fed a high fat diet they gain less weight than wild type littermates owing to reduced food intake. This results in healthy leaner Ppp1r15a mutant animals with reduced hepatic steatosis and improved insulin sensitivity, albeit with a possible modest defect in insulin secretion. By contrast, no weight differences are observed between wild type and Ppp1r15a deficient mice fed a standard diet. We conclude that female mice lacking the C-terminal PP1-binding domain of PPP1R15A show reduced dietary intake and preserved glucose tolerance. Our data indicate that this results in reduced weight gain and protection from diet-induced obesity.

Description: Abstract Coastal back‐barrier perched lakes are freshwater bodies that are elevated over sea‐level and are not directly subjected to the inflow of seawater. This study provides a detailed reconstruction of the Doniños back‐barrier perched lake that developed at the end of a small river valley in the rocky coast of the north‐west Iberian Peninsula during the Holocene transgression. Its sequence stratigraphy was reconstructed based on a core transect across the system, the analyses of its lithofacies and microfossil assemblages, and a high‐resolution radiocarbon‐based chronology. The Doniños perched lake was formed ca 4·5 ka bp. The setting of the perched lake was favoured by Late Holocene sea‐level stabilization and the formation of a barrier and back‐barrier basin, which was contemporaneous with the high systems tract period. This basin developed over marine and lagoonal sediments deposited between 10·2 ka bp and 8·0 ka bp, during rapidly rising sea‐level characteristic of the transgressive systems track period. At 1·1 ka bp, the barrier was breached and the perched lake was partially emptied, causing the erosion of the back‐barrier basin sediments and a significant sedimentary hiatus. Both enhanced storminess and human intervention were likely to be responsible for this event. After 1 ka bp, the barrier reclosed and the present‐day lake was reformed, with the water level reaching as high as 5 m above mean sea‐level. The depositional evolution of the Doniños system serves as a model of coastal back‐barrier perched lakes in coastal clastic systems that have developed over gently seaward‐dipping rugged substrates at small distances from the shoreline and under conditions of rising sea‐level and high sediment supply. A review of estuaries, back‐barrier lagoons, pocket beaches and back‐barrier perched lakes in the rocky coast of north‐west Spain shows that the elevation of the bedrock is the main factor controlling the origin and evolution of these systems.

Description: Abstract The Medieval Climate Anomaly (MCA) is a pre‐industrial phase of pronounced natural climate variability with a core period from 1000 to 1200 CE. The paper presents a synthesis that integrates palaeotemperature records from the Greater Mediterranean Region encompassing the past 1500 years based on multiproxy data from 79 published land and marine sites. MCA warming dominated the Western Mediterranean (Iberia, NW Africa) as well as the northern land areas of the Central and Eastern Mediterranean region. MCA cooling prevailed in the Canary Current Upwelling System, southern Levant and some sea areas of the Central and Eastern Mediterranean. Previous palaeoreconstructions suggest persistent positive Atlantic Multidecadal Oscillation (AMO+) and North Atlantic Oscillation (NAO+) conditions during the MCA, whilst the LIA was dominated by an AMO‐ and NAO‐ regime. During the past 150 years, AMO+ conditions are typically associated with warming episodes in the Mediterranean area. A similar relationship appears to have also been established during the MCA as the majority of all Mediterranean land sites experienced warm climate conditions. In contrast, the NAO typically leads to a characteristic west‐east temperature dipole pattern in the basin, as documented for the last decades. During NAO+ conditions the Western Mediterranean is generally warm (and dry), whilst large parts of the Central and Eastern Mediterranean are cold. Similar trends seem to have been developed during the MCA when the NAO+ regime led to consistent warming in the Western Mediterranean, whilst a significant number of sites with MCA cooling existed in the Central and Eastern Mediterranean.

Description: ABSTRACT We present a source-to-sink environmental magnetic study of a sediment core from Lake Sanabria (north-west Iberian Peninsula) and rocks of its catchment. The results indicate the occurrence of magnetite, and probably also pyrrhotite, in sediments accumulated between ca. 26 and 13 cal ka BP in a proglacial lake environment. These minerals also appear to dominate the magnetic assemblage of Palaeozoic rocks from the lake catchment. This indicates that sedimentation was then driven by the erosion of glacial flour, which suffered minimal chemical transformation due to a rapid and short routing to the lake. A sharp change in magnetic properties observed in the lake sediments between 13 and 12.6 cal ka BP reflects the rapid retreat of glaciers from the lake catchment. Sediments from the upper half of the studied sequence, accumulated after 12.6 cal ka BP in a lacustrine environment with strong fluvial influence, contain magnetite and smaller amounts of maghemite and greigite. We suggest that greigite grew authigenically under anoxic conditions caused by enhanced accumulation of organic matter into the lake. The occurrence of maghemite in these sediments suggests pedogenic activity in the then deglaciated lake catchment before the erosion and transportation of detrital material into the lake.

Description: Unpleasant emotional distraction can impair the retention of non-emotional information in working memory (WM). Research links the prefrontal cortex with the successful control of such biologically relevant distractors, although the temporal changes in this brain mechanism remain unexplored. We use magnetoencephalography to investigate the temporal dynamics of the cognitive control of both unpleasant and pleasant distraction, in the millisecond (ms) scale. Behavioral results demonstrate that pleasant events do not affect WM maintenance more than neutral ones. Neuroimaging results show that prefrontal cortices are recruited for the rapid detection of emotional distraction, at early latencies of the processing (70-130 ms). Later in the processing (360-450 ms), the dorsolateral, the medial and the orbital sections of the prefrontal cortex mediate the effective control of emotional distraction. In accordance with the behavioral performance, pleasant distractors do not require higher prefrontal activity than neutral ones. These findings extend our knowledge about the brain mechanisms of coping with emotional distraction in WM. In particular, they show for the first time that overriding the attentional capture triggered by emotional distractors, while maintaining task-relevant elements in mind, is based on the early detection of such linked-to-survival information and on its later cognitive control by the prefrontal cortex. Scientific Reports 5 doi: 10.1038/srep10046

Description: The February 2014 eruption of Kelud volcano (Indonesia) destroyed most of the instruments near it. We use remote seismic and infrasound sensors to reconstruct the eruptive sequence. The first explosions were relatively weak seismic and infrasound events. A major stratospheric ash injection occurred a few minutes later and produced long-lasting atmospheric and ground-coupled acoustic waves that were detected as far as 11,000 km by infrasound sensors, and up to 2,300 km away on seismometers. A seismic event followed ~12 minutes later and was recorded 7,000 km away by seismometers. We estimate a volcanic intensity [ Pyle , 2000] around 10.9, placing the 2014 Kelud eruption between the 1980 Mount St. Helens and 1991 Pinatubo eruptions intensities. We demonstrate how remote infrasound and seismic sensors are critical for the early detection of volcanic explosions, and how they can help to constrain and understand eruptive sequences

Description: Monitoring stations around the globe routinely detect microbarom signals with a dominant frequency of ∼0.2 Hz from regions of marine storminess. International Monitoring System (IMS) infrasound array IS59 in Kailua-Kona, Hawaii recorded clear signals in close proximity of Hurricanes Felicia and Neki of 2009 for a first-hand investigation of the detailed source mechanism through a hindcast analysis. A spectral wave model describes the tropical cyclone and ambient sea states through a system of two-way nested grids with forcing from a blended data set of global, regional, and cyclonic winds. The computed wave conditions are validated with altimetry measurements and utilized in an acoustic model to estimate the intensity and spatial distribution of the microbarom source. The model results elucidate origins of infrasound signals from the tropical cyclone waves as well as their interactions with the ambient conditions consisting of swells, wind seas, and storm waves from nearby systems. The positive correlation between the IS59 observations and the theoretical microbarom estimates, and the saturation of recorded signals from high-energy sources support the use of infrasound signals for inference of tropical cyclone waves.

Description: Varied acoustic signals were recorded at Kīlauea Volcano in mid-2007, coincident with dramatic changes in the volcano's activity. Prior to this time period, Pu'u 'Ō'ō crater produced near-continuous infrasonic tremor and was the primary source of degassing and lava effusion at Kīlauea. Collapse and draining of Pu'u 'Ō'ō crater in mid-June produced impulsive infrasonic signals and fluctuations in infrasonic tremor. Fissure eruptions on 19 June and 21 July were clearly located spatially and temporally using infrasound arrays. The 19 June eruption from a fissure approximately mid-way between Kīlauea's summit and Pu'u 'Ō'ō produced infrasound for ∼30 minutes—the only observed geophysical signal associated with the fissure opening. The infrasound signal from the 21 July eruption just east of Pu'u 'Ō'ō shows a clear azimuthal progression over time, indicative of fissure propagation over 12.9 hours. The total fissure propagation rate is relatively slow at 164 m/hr, although the fissure system ruptured discontinuously. Individual fissure rupture times are estimated using the acoustic data combined with visual observations.

Description: Microbaroms are continuous infrasonic signals with a dominant frequency around 0.2 Hz produced by ocean surface waves. Monitoring stations around the globe routinely detect strong microbaroms in the lee of tropical cyclones. We utilize a parametric wind model and a spectral wave model to construct the tropical cyclone wave field and a theoretical acoustic source model to describe the intensity, spatial distribution, and dynamics of microbarom sources. This approach excludes ambient wave conditions and facilitates a parametric analysis to elucidate the source mechanism within the storm. A stationary tropical cyclone produces the strongest microbarom signals at the center, where the waves generated by the cyclonic winds converge. As the tropical cyclone moves forward, the converging wave field becomes less coherent and lags and expands behind the storm center. The models predict a direct relation between the storm forward speed and the location of maximum microbarom source intensity consistent with the infrasonic observations from Hurricane Felicia 2009 in the North Central Pacific.