Publication Date:
2015-12-16
Description:
Article Down syndrome is associated with both central and peripheral nervous system dysfunction. Here, the authors report reduced sympathetic neural innervation in human Down syndrome tissues and a mouse model, and propose a role for RCAN1 trisomy in disrupted NGF receptor trafficking and neurotrophic support. Nature Communications doi: 10.1038/ncomms10119 Authors: Ami Patel, Naoya Yamashita, Maria Ascaño, Daniel Bodmer, Erica Boehm, Chantal Bodkin-Clarke, Yun Kyoung Ryu, Rejji Kuruvilla
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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