Publication Date:
2015-12-05
Description:
Article Drug molecules operate through physical interaction with specific cellular targets, and understanding this interaction is important for mechanisms and the potential therapeutic effect of drug candidates. Here, the authors show that bioluminescence resonance energy transfer can be used to monitor the intracellular engagement of a drug with its target. Nature Communications doi: 10.1038/ncomms10091 Authors: Matthew B. Robers, Melanie L. Dart, Carolyn C. Woodroofe, Chad A. Zimprich, Thomas A. Kirkland, Thomas Machleidt, Kevin R. Kupcho, Sergiy Levin, James R. Hartnett, Kristopher Zimmerman, Andrew L. Niles, Rachel Friedman Ohana, Danette L. Daniels, Michael Slater, Monika G. Wood, Mei Cong, Yi-Qiang Cheng, Keith V. Wood
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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