ISSN:
1573-6881
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract Results are presented which, taken with evidence developed by others, suggest a general mechanism for the entry and binding of exogenous ligands (including O2) at the “binuclear site” (CuB Fe a3) of the heme-copper oxidases. The mechanism includes a “ligand shuttle” wherein the obligatory waystation for incoming ligands is CuB and the binding of exogenous ligands at this site triggers the exchange and displacement of endogenous ligands at Fe a3. It is suggested that these ligand shuttle reactions might be functionally important in providing a coupling mechanism for electron transfer and proton translocation. Scenarios as to how this might happen are delineated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00762859
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