ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
4,5-Epoxymorphinan
;
Nalbuphine hydrochloride injection
;
Stability assays
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A stability-indicating liquid chromatographic method has been developed for the determination of nalbuphine hydrochloride, methylparaben, and propylparaben in nalbuphine hydrochloride injection. Reversed-phase chromatography was carried out using a mobile phase containing 0.05 % trifuoroacetic acid, acetonitrile, and tetrahydrofuran. Quantitation was achieved with UV detection at 280 nm. Validation data for linearity, accuracy, precision, specificity, and robustness are presented. The chromatographic system resolves nalbuphine from synthetic impurities and degradation products.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02467488
Permalink