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  • 1
    Electronic Resource
    Electronic Resource
    Hsp70 and aging (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 1092-1098 
    Details
    ISSN: 1420-9071
    Keywords: Aging ; liver ; transcription ; heat shock transcription factor ; rat ; senescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An alteration in the ability of cells to express heat shock proteins could be physiologically important in aging because all living organisms show a reduced ability to respond to stress with increasing age. Using hepatocytes freshly isolated from young adult and old rats, we have shown that the induction of hsp70 expression by heat shock is reduced approximately 50% with age. The decrease in hsp70 expression occurs at the level of transcription and appears to arise from a defect in the heat shock transcription factor. Other investigators have also shown that the induction of hsp70 expression by heat shock as well as other stresses declines significantly with age in a variety of tissues from rats as well as mononuclear cells from human subjects. In addition, a decrease in the inducibility of hsp70 is observed with cell senescence in cultured cells. Therefore, it appears that a reduced ability to express hsp70 in response to stress may be a common phenomenon underlying the aging process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923466
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  • 2
    Electronic Resource
    Electronic Resource
    Acetylcholine content in brain white matter as determined after extraction with a new solvent mixture (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 566-567 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Eine stark verbesserte Methode zur Extraktion und damit zur Bestimmung von Acetylcholin in der weissen Substanz von Ratten- und Meerschweinchengehirn, die bis zu 20–40% höhere Werte ergibt als die bisherigen Verfahren, wird beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01898519
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  • 3
    Electronic Resource
    Electronic Resource
    Determination method for residual 1,3-dichloro-and 1,3,5-trichloro-2-(4-nitrophenoxy) benzene (nip and cnp) in fish and shellfish (1979)
    Springer
    Bulletin of environmental contamination and toxicology 23 (1979), S. 57-63 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01769916
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  • 4
    Electronic Resource
    Electronic Resource
    Application of LGA to solve mixing in a simplified stirred tank by a parallel computer (1999)
    Springer
    Computational mechanics 23 (1999), S. 182-189 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Application of lattice gas automaton (LGA) to engineering will be examined by dealing with mixing of two component flow without chemical reaction in a simplified stirred tank. In mechanical engineering, it is important to know quality and accumulation rate of products which depend essentially on mixing of raw materials. Mixing is usually formulated by partial differential equations of conservation laws and empirical formulae, and solved numerically by derived finite difference equations. LGA will be capable of calculating the fine structure of time-dependent interfacial behavior mesoscopically, since this has advantages of describing pattern formation of mixture in detail and is good at parallel computation. Parallel computation must now be a selected issue to determine whether LGA is applicable to practical problems. Computing power intends us to approach complex flow by new concept. This means that days of pure fluid dynamics are over and chemical process, phase change, material behavior must now be taken into account. The present example can described as a numerically intensive parallel computing problem as far as the number of PEs is increased up to 32 in the present numerical experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004660050399
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  • 5
    Electronic Resource
    Electronic Resource
    Numerical experiment on interaction of solitons describing recurrence of initial state (1989)
    Springer
    Computational mechanics 5 (1989), S. 273-281 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A soliton is the wave which propagates in the form of stable bulk with concentrated energy. Zabusky and Kruskal discovered it in 1965 by solving numerically the K-dV equation, and consequently a variety of analytical methods were established for studying its physical property to introduce the new field of modern physics. This paper succeeds in demonstrating computationally interaction of solitons concerning recurrence of the initial state suggested by Zabusky and Kruskal where ambiguity about their numerical analysis has prevented us from obtaining stable solution representing recurrent phenomenon for a long time. Here numerical experiment enables us to examine instability occasioning in the leapfrog method with a function of the initial condition which served as a key parameter. It is clarified that: (i) this finite difference approximation is available to describe only weakly coupled interaction of solitons, (ii) on linear analysis point of view, instability results from increasing unstable numerical mode of the higher Fourier components which was attributed to dispersive property of this difference method and (iii) instability originates in a sharp solitary wave which was standing still at the point of its birth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01046944
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  • 6
    Electronic Resource
    Electronic Resource
    Preservation of glycogen in decalcified hard tissues (1970)
    Springer
    Histochemistry and cell biology 21 (1970), S. 249-256 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Various fixatives and fixation procedures were tested to evaluate their effects on the preservation of glycogen in sections of decalcified hard tissues. Lower jaws from 1-day-old rats were chosen for the observations. An aqueous solution of glutaraldehyde showed poor preservation of glycogen in the tissues even when employed in the perfusion procedure. Freeze-drying and formaldehyde vapour fixation preserved it much better, but glycogen was still lost to some extent. Freeze-substitution with acetone and various alcoholic fixatives gave a poor result, unless the tissues were fixed with cyanuric chloride. Cyanuric chloride in methanol containing N-methyl morphorine was the best fixative for the preservation of glycogen in the sections. A combination of freeze-substitution with the cyanuric chloride solution, decalcification with the Jenkins's fluid, and subsequent double-embedding in celloidin and paraffin was recommendable for an excellent glycogen preservation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304216
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  • 7
    Electronic Resource
    Electronic Resource
    Circadian fluctuation of susceptibility to haloperidol under constant conditions (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 625-626 
    Details
    ISSN: 1420-9071
    Keywords: Haloperidol ; circadian rhythm ; sedation ; antiapomorphine effect ; constant condition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An endogenous circadian rhythm of the sedative and antiapomorphine effects of haloperidol was observed under constant conditions for 7 days as well as under an entrained light-dark cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02126357
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  • 8
    Electronic Resource
    Electronic Resource
    Quantitative analysis by thin-layer chromatography with secondary ion mass spectrometry (1991)
    Springer
    Chromatographia 32 (1991), S. 179-181 
    Details
    ISSN: 1612-1112
    Keywords: Thin-layer chromatography ; Secondary ion mass spectrometry ; Nicergoline ; Semisynthetic alkaloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A direct combination of thin-layer chromatography with secondary ion mass spectrometry (TLC/SIMS) provides a method for the quantitative analysis of thermally unstable compounds or compounds of low volatility such as nicergoline. The method is very simple and has excellent precision. The analysis was performed by using an aluminium TLC plate and a mixture of methylene chloride, acetone, and distilled water as a developing solvent. After development the portion of the plate with the nicergoline and the internal standard spots was cut off the TLC plate, and was attached to the SIMS holder directly. The amount of nicergoline was determined from the ratio of the fragment ion intensity of the nicergoline to the internal standard. The calibration curve was linear, and the detection limit was 10 ng at a signal-to-noise ratio of 5. This method should be considered for application to the determination of drugs in biological samples and also for the determination of possible impurities and decomposition products in drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02325023
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  • 9
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    Hsp70 and aging (1994)
    Springer
    Details
    Publication Date: 1994-11-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 10
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    Circadian fluctuation of susceptibility to haloperidol under constant conditions (1987)
    Springer
    Details
    Publication Date: 1987-06-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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