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  • Springer  (3)
  • 1
    Digitale Medien
    Digitale Medien
    The calmodulin content of normal and leukaemic lymphocytes (1985)
    Springer
    Bioscience reports 5 (1985), S. 721-727 
    Details
    ISSN: 1573-4935
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Normal human peripheral blood mononuclear cells (PBMC) and leukaemic cell lines (three of human and one of gibbon origin) were found to contain similar levels of calmodulin (CaM) when expressed relative to the total cell protein. Two of the cell lines examined further were found to contain much higher amounts of CaM per cell (up to 5-fold) than PBMC but this was readily explained by their much greater cell size. Variations in CaM levels were noted during culture of both PBMC and leukaemic cells which were apparently independent of the percentage of cells undergoing active division in these cultures. These results do not support, the contention that transformed cells contain a higher proportion of CaM than normal cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01119869
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The influence of interferon alpha and gamma, singly or in combination on human natural cell mediated cytotoxicity (1989)
    Springer
    Bioscience reports 9 (1989), S. 549-557 
    Details
    ISSN: 1573-4935
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The influence of interferon alpha and gamma alone or in combination on the augmentation of human natural cytotoxicity was studied. Treatment of peripheral blood lymphocytes with IFN-α led to a rapid augmentation of NK activity, in contrast to IFN-γ where target cell killing was observed only following 18 hrs exposure of lymphocytes to IFN-γ. The results of the single cell assay paralleled those obtained using the Chromium release test, but neither interferon type caused an increase in the number of target binding lymphocytes. The combined effect of IFN-α and IFN-γ in stimulating human natural cytotoxicity demonstrated individual lymphocyte responses to be variable. Exposure of lymphocytes to IFN-α and IFN-γ for 18 hrs prior to assay for cytotoxicity usually decreased the level of cytotoxicity compared with control values, whereas other treatment regimes gave an additive and sometimes synergistic effect. Only treatment with IFN-α for 18 hrs and IFN-γ for one hr produced a synergistic response in the majority of individuals tested. We conclude from this study that individual responses to IFN-α and IFN-γ alone or in combination are variable and dependent upon timing of exposure of lymphocytes to individual interferon types, and possibly reflects the donor status at the time of sampling.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01119797
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    Evidence for the involvement of calmodulin in natural cytotoxicity using a range of calmodulin antagonists of varying potency and improved specificity (1987)
    Springer
    Bioscience reports 7 (1987), S. 771-775 
    Details
    ISSN: 1573-4935
    Schlagwort(e): calmodulin ; cytotoxicity ; NK cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The calmodulin antagonist W7 and 4 of its analogues were examined for their ability to inhibit human NK cell mediated cytotoxicity. With the exception of one of these compounds, which is extremely hydrophobic, there was a good correlation between the ability of drugs to inhibit human NK antitumour cytotoxicity and calmodulin-dependent phosphodiesterase activity in vitro. The most potent of the compounds, 5-iodo-l-C8, an analogue of W7, has an IC50 of 3 μM upon biological and biochemical assay. This particular compound is both more potent and specific than the parent compound W7, is non-toxic to cells over the range used and is also capable of inhibiting the biological activity of NK cells upon pre-treatment of the effector cells, inferring the mechanism of NK cytotoxicity to be calmodulin dependent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01116749
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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