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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 20 (1991), S. 366-370 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Levels of 2,3,7,8 tetrachlorodibenzodioxin (TCDD) were determined in both striated muscle (fillets) and whole body extracts of fish specimens harvested during a two-year period (1987–1989) from the Pigeon River (between Hartford and Newport) of Eastern Tennessee (USA). Whole body (wet weight) fish extract levels as high as 117 μg/kg body weight and composite fish fillet (wet weight) extract levels as high as 87 μg/kg fillet weight were observed. Pure TCDD was found to be highly toxic to theSalmonella typhimurium strains TA97, TA98, and TA100 at dosages which exceeded 825 ng TCDD/ml in the top agar of the Ames Salmonella assay. An 825 ng/ml TCDD dosage was not mutagenic to any of the tested Salmonella strains, either with or without metabolic activation (S9 mix). However, when acidic fish extracts from the Pigeon River were tested for mutagenicity, most of the fish extracts were mutagenic to Salmonella strains TA97, TA98, and TA100. These mutagenic extracts also demonstrated mutagenic dose-response curves. Other chemicals within the extracts as well as synergistic effects may account for the mutagenicity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 25 (1993), S. 260-266 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The interaction between carcinogens and DNA is believed to initiate neoplastic transformation, but evidence suggests that epigenetic mechanisms may also be of importance. Because the histone proteins have important roles in chromatin structure and cellular function, they provide a reasonably well understood epigenetically-based system for the detection of carcinogens. In this study, human foreskin fibroblastic cells were exposed to one of several mutagens and/or carcinogens for 3, 12, or 24 h to determine if induced histone modification may be a means of predicting chemical carcinogenicity. Butyric acid (5 mM), known to result in acetylation of histones H3 and H4, and 12-O-tetradecanoylphorbol-13-acetate (3 μM), known to result in phosphorylated histone H1, were tested initially. Electrophoresis of the histone fractions was capable of resolving multiple forms of histones H1, H3, and H4. Propane sultone (0.1 mM) induced a broadening of the H2A and H2B bands after a 24 h exposure and carbon tetrachloride (1 mM) induced the formation of new histone forms in the H1 fraction after 24 h and in the H3 fraction after 3 h. Experimental variability limited the statistically significant modifications to carbon tetrachloride and propane sultone, two known carcinogens, where new forms of modified histone were detected. Therefore, the histone modification assay, with further experimentation, may be an alternate method of detecting carcinogens, especially when conventional genotoxic tests prove unreliable.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 19 (1990), S. 657-664 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The mutagenic activity of wastewater was followed during conventional activated sludge treatment at a municipal plant. Raw wastewater was initially screened for mutagenic potential, using the AmesSalmonella/mammalian microsomal test and employer tester strains. The combined raw wastewater produced dose-related mutagenic responses in the presence of S9 metabolic activation. Raw wastewater from domestic sources alone was not mutagenic. Mutagenic activity was observed throughout the treatment process. Activated sludge prior to chlorination contained the highest specific mutagenic activity. Chlorination decreased the specific mutagenic activity at pH 11. Mutagenic activity in municipal wastewater containing industrial discharges is not removed by conventional treatment processes and can be enhanced by activated sludge treatment.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of regulatory economics 16 (1999), S. 297-306 
    ISSN: 1573-0468
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Strategic positioning and potential cost savings are popular explanations for growing consolidation in the wireless telephone industry. This research estimates economies of scale for a large panel of GTE Wireless cellular market areas. Contrary to previous findings, our results indicate scale economies exist throughout the system and provide a rationale for the industry trend of consolidation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 11 (1979), S. 71-75 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Muscular tissue specimens of adult grouse, quail and woodcock from the rural counties of upper East Tennessee have been analyzed by gas chromatography for the organochlorine pesticides lindane, heptachlor, endrin, aldrin, dieldrin, DDT (total) and methoxychlor. Procedures for the analyses are described. The pesticidal levels in the muscle of all gamebirds exceeded the acceptable levels shown in governmental sources and professional journals. The observed concentrations constitute a serious threat to the wildlife of the region and permit accumulation and magnification even in man, who eats gamebirds as a part of his diet.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 29 (1986), S. 361-371 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Heavy metal residues (i.e., As, Cd, Cu, Pb, Mn, Hg, and Zn) were determined in striated muscle of 268 fish specimens harvested during a 5-yr period (1980–1984) from several aquatic systems in east Tennessee (U.S.A.). Elevated concentrations of Hg, Mn, and Cd were found in the muscle of fish from several of the aquatic systems studied; concentrations of Hg exceeded the U.S. Food and Drug Administration action level of 1.0 ppm for food intended for human consumption. In general, the concentrations of the other metals in fish muscle were low. Moreover, muscle metal content did not vary among the three fish groups (i.e., game fish, catfish, and rough fish) investigated at any one of the nine sampling stations established. The results of this study are in agreement with the 1978–1979 pilot survey of Young and Blevins (1981) conducted at the same sampling stations. It appears that, in this region of Tennessee, heavy metal contamination of fish tissues has neither improved nor deteriorated during the last 5 yr.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1572-9540
    Keywords: high-pressure ; Mössbauer spectroscopy ; Mott insulators ; magnetism ; spin crossover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Combining the methods of Mössbauer spectroscopy, synchrotron XRD, and resistivity and using diamond-anvil cells enables the discovery and studies of new phenomena in magnetism and electronic correlation at high density. It is shown that Hund's rule concerning the high-spin state in TM-compounds does not hold in this regime resulting in spin-crossover and collapse of the magnetic state for even-valence TM ions and for the decline of magnetic exchange in the odd-valence species. This mechanism competes with the breakdown of the d–d electron correlation (Mott transition) in transforming the Mott insulators into normal metals. The experimental issues are described and examples of magnetic studies at very high-pressures are portrayed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 53 (1990), S. 385-390 
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The Mössbauer effect in129I in conjunction with Diamond-Anvil-Cell high pressure techniques was applied to investigate the high pressure phase(s) of the molecular crystal GeI4. The129IQuadrupole Interaction was the main probe for characterizing theintermolecular structural transformation with pressure. With increasing pressure, at about 15 GPa, the onset of a partial molecular-association phase (HP1) is first observed. In HP1 two out of the four iodines strongly overlap to form linear chains of GeI4. The HP1 phase coexists with the low pressure (LP) molecular phase, but its population increases with increasing pressure. AtP=20 GPa a second high pressure phase (HP2) is identified where all four iodines strongly overlap to form a three dimensional, fully molecular-associated structure. With increasing pressure and atP〉20 GPa, HP2 is the only phase up toP=34 GPa, the highest pressure used. A significant hysteresis of the relative abundances with pressure is observed. The isomer shift of the HP2 and HP1 structures is considerably larger than that of the LP one.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 58 (1990), S. 2513-2518 
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The 40-sec, 88-keV, first-excited state of109Ag provides a difficult case for the observation of the Mössbauer effect. The major difficulty is associated with the long lifetime which corresponds to a natural linewidth of only 10−17 eV. Our results indicate a 0.2% Mössbauer effect.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 93 (1994), S. 1445-1451 
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract After perfecting a technique to manufacture extremely pure, homogeneous, smallconcentration Sn in Pb samples, we have measured the Debye-Waller factor over the temperature range of 4 to 300 K. Our data show some evidence of a line broadening between 4 and 50 K which may be accounted for by the spin-density wave model of lead proposed by A. Overhauser. [1]. Between 77 K and room temperature, we find a temperature dependence to the recoilless fraction consistent with a Debye model (Debye temperature = 107(2) K). Moreover, we find no evidence of a sudden precipitous falloff of the recoilless fraction, as was reported by Schechter et al. in 1989. The origin of this difference is discussed.
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