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  • 1
    Electronic Resource
    Electronic Resource
    Progesterone receptors are expressed in human osteoblast-like cell lines and in primary human osteoblast cultures (1995)
    Springer
    Calcified tissue international 57 (1995), S. 436-441 
    Details
    ISSN: 1432-0827
    Keywords: Human osteoblast ; Progesterone receptor ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Expression of progesterone receptors (PR) was studied in human osteoblast-like cell lines and primary human osteoblast cultures at the molecular level. Using the sensitive reverse transcriptase polymerase chain reaction (RT-PCR) and oligonucleotide primers which flank the progesterone-binding domain of human PR, progesterone receptor (PR) mRNA was detected in three osteoblast-like cell lines-HOS-TE85, MG-63, and SAOS-2. When compared with β-actin gene expression, levels of PRmRNA transcripts varied between cell lines (PRmRNA in HOS-TE85〉MG-63 ≫ SAOS-2). In addition, RT-PCR confirmed the presence of PRmRNA transcripts in primary human osteoblast cells cultured from collagenase-treated bone. Immunostaining was used to visualize PR protein in cells. All osteoblast-like cell lines showed specific staining for PR. Immunoreactivity was distributed equally in the nucleus and cytoplasm. The level of staining was significantly lower than that detected in PR-positive MCF-7 breast cancer cells though well above background levels obtained for PR-negative HeLa cells. The finding that PR is expressed at both the level of mRNA and protein in several osteoblast-like cell lines as well as in human primary osteoblast cultures indicates that bone-forming osteoblast cells are direct targets for progesterone action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301947
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  • 2
    Electronic Resource
    Electronic Resource
    Interfacial reaction kinetics (2000)
    Springer
    The European physical journal 1 (2000), S. 159-177 
    Details
    ISSN: 1292-895X
    Keywords: PACS. 05.40.-a Fluctuation phenomena, random processes, noise, and Brownian motion - 68.45.Da Adsorption and desorption kinetics; evaporation and condensation - 82.35.+t Polymer reactions and polymerization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We study irreversible A-B reaction kinetics at a fixed interface separating two immiscible bulk phases, A and B. Coupled equations are derived for the hierarchy of many-body correlation functions. Postulating physically motivated bounds, closed equations result without the need for ad hoc decoupling approximations. We consider general dynamical exponent z, where is the rms diffusion distance after time t. At short times the number of reactions per unit area, , is 2nd order in the far-field reactant densities . For spatial dimensions dabove a critical value , simple mean field (MF) kinetics pertain, where Qb is the local reactivity. For low dimensions , this MF regime is followed by 2nd order diffusion controlled (DC) kinetics, , provided . Logarithmic corrections arise in marginal cases. At long times, a cross-over to 1st order DC kinetics occurs: . A density depletion hole grows on the more dilute A side. In the symmetric case ( ), when the long time decay of the interfacial reactant density, , is determined by fluctuations in the initial reactant distribution, giving . Correspondingly, A-rich and B-rich regions develop at the interface analogously to the segregation effects established by other authors for the bulk reaction . For fluctuations are unimportant: local mean field theory applies at the interface (joint density distribution approximating the product of A and B densities) and . We apply our results to simple molecules (Fickian diffusion, z=2) and to several models of short-time polymer diffusion (z〉2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014596
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  • 3
    Electronic Resource
    Electronic Resource
    Purification of RBF-2, a transcription factor with specificity for the most conservedcis-element of naturally occurring HIV-1 LTRs (1999)
    Springer
    Journal of biomedical science 6 (1999), S. 320-332 
    Details
    ISSN: 1423-0127
    Keywords: RBF-2 purification ; HIV-1 LTR ; Transcription factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The combination of high turnover and error-prone reverse transcription results in naturally occurring human immunodeficiency virus-1 long terminal repeats that differ considerably from the prototype sequence. Although no transcription-factor-binding site escapes mutation, the only mutated site that appears to be invariably compensated by co-occurrence of its duplication is the RBE III site, a target for the transcription factor RBF-2. In this work, we characterize RBF-2 further by biochemical purification. RBF-2 was purified by chromatography on heparin agarose and Mono-Q ion exchange chromatography, followed by affinity chromatography on mutant and wild-type RBE III oligonucleotide columns. The purified RBF-2 preparation contained 4 major and 1 minor polypeptides of 50, 100, 110, 120 and 125 kD, as detected by silver staining in SDS-PAGE gels. UV cross-linking revealed a specific 100-kD species, indicating that this protein likely represents the DNA-binding component of a complex. A second factor with DNA-binding specificity similar to that of RBF-2, called RBF-B, was also identified by heparin-agarose fractionation, which suggests that effects of the RBE IIIcis-element may be mediated by a combination of factors in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253521
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  • 4
    Electronic Resource
    Electronic Resource
    Pericentric inversion of “fluorescent” segment in chromosome No. 3 (1974)
    Springer
    Human genetics 〈Berlin〉 22 (1974), S. 343-346 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Während einer kurzen Zeitspanne wurden 3 Fälle einer perizentrischen Inversion des “Fluorescenz”-Segments eines Chromosomes Nr. 3 identifiziert. Alle 3 Probandinnen hatten leichten Schwachsinn und waren die Patientinnen eines Psychiatrischen Krankenhauses. 1 Patientin hat die Inversion von ihrem Vater und Großvater geerb; die phenotypisch normal waren.
    Notes: Abstract During a short time span we identified 3 unrelated cases of pericentric inversion of the “fluorescent” segment in one chromosome No. 3. All 3 propositae were mentally defective female patients of a mental hospital; 1 case was familial with phenotypically normal father and grandfather.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295495
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  • 5
    Electronic Resource
    Electronic Resource
    Reaction kinetics in polymer melts (1998)
    Springer
    The European physical journal 6 (1998), S. 363-372 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 82.35.+t Polymer reactions and polymerization - 05.40.+j Fluctuation phenomena, random processes, and Brownian motion - 05.70.Ln Nonequilibrium thermodynamics, irreversible processes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We study the reaction kinetics of end-functionalized polymer chains dispersed in an unreactive polymer melt. Starting from an infinite hierarchy of coupled equations for many-chain correlation functions, a closed equation is derived for the 2nd order rate constant k after postulating simple physical bounds. Our results generalize previous 2-chain treatments (valid in dilute reactants limit) by Doi [#!doi:inter2!#], de Gennes [#!gennes:polreactionsiandii!#], and Friedman and O'Shaughnessy [#!ben:interdil_all_aip!#], to arbitrary initial reactive group density n0 and local chemical reactivity Q. Simple mean field (MF) kinetics apply at short times, .For high Q, a transition occurs to diffusion-controlled (DC) kinetics with (where xt is rms monomer displacement in time t) leading to a density decay . If n0 exceeds the chain overlap threshold, this behavior is followed by a regime where during which k has the same power law dependence in time, , but possibly different numerical coefficient. For unentangled melts this gives while for entangled cases one or more of the successive regimes ,t -3/8 and t -3/4 may be realized depending on the magnitudes of Q and n0. Kinetics at times longer than the longest polymer relaxation time are always MF. If a DC regime has developed before then the long time rate constant is where R is the coil radius. We propose measuring the above kinetics in a model experiment where radical end groups are generated by photolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050562
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  • 6
    Electronic Resource
    Electronic Resource
    Towards a new way to measure power: Applying conjoint analysis to group decisions (1989)
    Springer
    Marketing letters 1 (1989), S. 37-46 
    Details
    ISSN: 1573-059X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract This paper presents some preliminary development towards a methodology for measuring power in a group purchase decision. We define power as the capacity of an individual to change the probability of an alternative being chosen by expressing an opinion about that alternative. We present a linear model that relates the group members' preferences to the probability that a given alternative will be chosen. The model parameters reflect specific measures of power and can be estimated by conjoint analysis. We present the results of a pilot field study, conducted on a sample of purchasing managers, which favorably assesses certain psychometric properties of the resulting measures for dyads.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436147
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  • 7
    Electronic Resource
    Electronic Resource
    Single-beam atmospheric transverse velocity measurement (1978)
    Springer
    Optical and quantum electronics 10 (1978), S. 270-272 
    Details
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208859
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  • 8
    Electronic Resource
    Electronic Resource
    Long range anemometry using a CO2 laser (1972)
    Springer
    Optical and quantum electronics 4 (1972), S. 379-384 
    Details
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract A CO2 laser anemometer is described which gives a real-time, continuous, measure of one component of wind velocity. Results are presented of a series of trials in which the laser anemometer is compared with a conventional propeller anemometer at ranges up to 50 m from the laser. Very good agreement is observed between the outputs of the two devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01414142
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  • 9
    Electronic Resource
    Electronic Resource
    A reexamination of the Internal Auditors' Code of Ethics (1995)
    Springer
    Journal of business ethics 14 (1995), S. 949-957 
    Details
    ISSN: 1573-0697
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Economics
    Notes: Abstract This study empirically examined the views of Certified Internal Auditors (CIAs) concerning the role of Code of Ethics for members of the Institute of Internal Auditors. It is a continuation of an earlier study which examined the usefulness of the Code to CIAs. Among the questions asked were what is the primary reason for the Code of Ethics, how useful is it, have you used it, should more enforcement actions be taken against members who violate the Code, and what are the legal and moral responsibilities of the CIA to report serious ethical violations, e.g., environmental pollution, to outsiders when top management and the board of directors are aware of the matter but are not doing anything to correct it. The results indicate strong support for the Code, its enforcement, and use as an instrument to encourage the internal flow of ethical behavior by embers and others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00882073
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  • 10
    Electronic Resource
    Electronic Resource
    Phase II study of fazarabine (NSC 281272) in patients with metastatic colon cancer (1993)
    Springer
    Investigational new drugs 11 (1993), S. 71-74 
    Details
    ISSN: 1573-0646
    Keywords: fazarabine (arabinofuranosyl-5-azacytosine ara-AC, NSC 281272) ; phase II ; colon cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fazarabine (Arabinofuranosyl-5-azacytosine) is a synthetic pyrimidine nucleoside which combines the arabinose sugar of cytosine arabinoside with the triazine base of 5-azacytidine. It has demonstrated activity against a variety of human solid tumor xenografts including colon, lung and breast cancers. Eighteen patients with refractory metastatic colon cancer were enrolled in a phase II trial of fazarabine. The drug was administered as a 72 hr continuous infusion every 3–4 weeks; the starting dose was 2 mg/m2/hr as established in a previous phase I study. The major toxicity was neutropenia, as predicted from the phase I study. The median time to nadir for cycle 1 was 20 days, with a median granulocyte count of 437/μl (range 36–1600/μl); recovery was within 2–4 days, with only one incidence of fever and neutropenia in 42 cycles. Especially noted for their absence were thrombocytopenia, nausea, vomiting and stomatitis. No objective clinical responses were seen; one patient had stabilization of rapidly growing liver metastases for a period of 7 months. In view of fazarabine's narrow range of toxicities, future dose intensification trials utilizing fazarabine in combination with hematopoietic growth factors are worthy of consideration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873915
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