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  • 1
    Electronic Resource
    Electronic Resource
    Expression of ecdysteroid-regulated genes is reduced specifically in the wing discs of the wing-deficient mutant (fl) of Bombyx mori (2000)
    Springer
    Development genes and evolution 210 (2000), S. 120-128 
    Details
    ISSN: 1432-041X
    Keywords: Key words Key words: Wing-deficient mutant fl ; Bombyx mori ; Wing imaginal discs ; Ecdysteroid ; Metamorphosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The wing-deficient mutant, flügellos (fl), of the silkworm, lacks four wings in the pupa and the adult. Previous studies have suggested that the fl wing discs lose responsiveness to ecdysteroid during metamorphosis. To test this hypothesis at the molecular level we compared the expression of 12 genes when the wing discs from the wild-type (WT) and fl larvae were cultured in the presence or absence of 20-hydroxyecdysone (20E). Most of the genes tested here, ecdysteroid-inducible (EcR-A, -B1,and E75) and noninducible genes (actin A3, β-tubulin, apterous (ap), USP, and BHR38) were normally expressed in the fl wing discs. However, the amounts of mRNAs of two ecdysteroid-inducible genes, BHR3 (early-late gene; Bombyx homologue to DHR3 and MHR3) and Urbain (wing-specific late gene), were reduced to about 50% and 20% of WT in the cultured fl wing discs, respectively. We analyzed developmental profiles of these mRNAs during metamorphosis. They also demonstrated decreased BHR3 and Urbain mRNA 2 days after the onset of wandering. This reduction in transcription of BHR3 in the fl mutant was observed only in the wing disc, not in the testis and fatbody. These results imply that the aberrant expression of the fl gene affects the downstream pathway of ecdysteroid signaling specifically in the wing discs and thus leads to a deficiency in wing formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050018
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction between valproate formulation and phenytoin concentrations (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 61-63 
    Details
    ISSN: 1432-1041
    Keywords: Valproate ; Phenytoin ; drug interaction ; slow-release tablet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was replaced by the same dose as a slow-release tablet. The mean plasma phenytoin level rose significantly from 14.4 to 18.7 μg·ml−1. Nine of eleven patients had markedly increased phenytoin levels (by 21 to 72%), and two developed toxic symptoms. The results indicate that changing valproate formulations can cause major alterations in the plasma concentration of co-administered phenytoin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202174
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  • 3
    Electronic Resource
    Electronic Resource
    Establishment and Characterization of a Culture System for Enzymatically Released Rat Dental Pulp Cells (2000)
    Springer
    Calcified tissue international 66 (2000), S. 139-144 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Dental pulp cells — Cell culture — Odontoblast-like cells — Differentiation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. To establish a cell culture system that reflects the dentin formation in dental pulp tissue, we used dental pulp cells enzymatically isolated from rat incisor teeth. During the 20-day culture period, the cells exhibited various phenotypes of the odontoblast differentiation process, from the immature stage to the terminal mineralization stage. The cells began to form the mineralized nodules from day 10, and the nodules became larger by day 20. Alkaline phosphatase (ALP)-positive cells surrounded the mineralized nodules. The ALP activity in the cell layers was maximal on day 5, and gradually decreased to day 20. The calcium content in the cell layers was very low by day 10, and significantly increased from day 15. Sulfated glycosaminoglycans (GAGs) contained in the cell layers increased by day 15, but the content then decreased by day 20. The dental pulp cells produced a small amount of osteocalcin that was released into the culture medium by day 10, and the amount secreted increased markedly from day 15. The expression of osteocalcin and parathyroid hormone/parathyroid hormone-related peptide (PTH/PTHrP) receptor mRNA was evident as early as day 5, and the expression of each gradually increased with the number of days in culture. Dentin matrix protein (Dmp1) mRNA gene transcripts were identified by use of the reverse transcription polymerase chain reaction (RT-PCR) in the cells throughout the culture period. The present results demonstrate that this culture system is useful for studying the differentiation process of the odontoblast-like cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230010028
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  • 4
    Electronic Resource
    Electronic Resource
    Coulomb excitation of154Sm (1992)
    Springer
    The European physical journal 343 (1992), S. 373-374 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Re ; 23.20.Lv ; 27.70.+q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The deformed nucleus154Sm was studied by Coulomb excitation with NORDBALL by using a58Ni beam. The ground-state band, the beta band, the gamma band and the octupole band (K=0-) were excited up to the 16+ state, the 6+ state, the 6+ state and the 13-state, respectively. A new band was established from 6+ to 14+ on the basis of the gamma-gamma coincidence spectra. The excitation probability of the new band is larger than that of the beta band.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291541
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  • 5
    Electronic Resource
    Electronic Resource
    Differential effects of the serotonin receptors on cultured rat cerebral cortical neurons (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 233-236 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Serotonin; ligand-gated receptor; G-protein-coupled receptor; patch-clamp; cerebral cortical neuron.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Effects of serotonin (5-HT) on cerebral cortical neurons were examined by patch clamp techniques. 5-HT produced a variety of responses such as outward (19/73 patches/neurons), slow inward (15/73 patches/neurons), fast inward (8/73 patches/neurons), and mixed currents (initially fast inward deflection followed by an outward response: 2/73 patches/neurons), with a latency of 12 sec, 15 sec, 0 sec, and 0 sec respectively, at a holding potential of −60 mV in whole-cell patches. The fast inward currents were again evoked by a selective 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (CPBG). In the cell-attached patch clamp configuration, 5-HT inside the patch pipette elicited single channel currents with slope conductances of 42 pS and 132 pS (4/42 patches/neurons). CPBG inside the patch pipette evoked inward single channel currents with a lower slope conductance of 41 pS (3/23 patches/neurons). In contrast, application of 5-HT or a 5-HT2 receptor agonist, α-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope conductance of 140 pS (8/30 patches/neurons) or 135 pS (6/20 patches/neurons), respectively. These results indicate that the outward and fast inward currents may be mediated respectively by the 5-HT2 receptor, which is coupled to a G-protein, and by the 5-HT3 receptor, which contains the non-selective cation channel, and that the mixed type may be caused by both the 5-HT2 and 5-HT3 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000596
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  • 6
    Electronic Resource
    Electronic Resource
    High-pressure Reaction of Propargyl Alcohol (1998)
    Springer
    Journal of materials science 17 (1998), S. 1539-1540 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006545811442
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  • 7
    Electronic Resource
    Electronic Resource
    Electro-rheological properties of suspension of carbonaceous particles (1995)
    Springer
    Journal of materials science 14 (1995), S. 623-625 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586159
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  • 8
    Electronic Resource
    Electronic Resource
    Crystallization of a nylon-6-clay hybrid by injection moulding under elevated pressure (1993)
    Springer
    Journal of materials science 12 (1993), S. 1714-1715 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418841
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  • 9
    Electronic Resource
    Electronic Resource
    Optical limiting property of fullerene-containing polystyrene (1997)
    Springer
    Journal of materials science 16 (1997), S. 2029-2031 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018500531390
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  • 10
    Electronic Resource
    Electronic Resource
    High-pressure synthesis of polyphenylacetylene (1995)
    Springer
    Journal of materials science 14 (1995), S. 1583-1584 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455422
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