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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 81 (1984), S. 83-87 
    ISSN: 1432-1424
    Keywords: pancreatic acinar cells ; nonselective cation channel ; Ca2+-sensitivity ; patch clamp ; single-channel recording
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The Ca2+-activated nonselective cation channel in mouse pancreatic acini has been studied with the help of patch-clamp single-channel current recording in both the cell-attached conformation and in excised inside-out membrane patches. In intact resting mouse pancreatic acinar cells no unitary activity was observed. Adding saponin to the bath solution to disrupt the plasma membrane (apart from the isolated patch membrane from which current recording was made) evoked unitary inward current steps when the free ionized Ca2+ concentration in the bath ([Ca2+] i ) was 5×10−8 m or above. When an electrically isolated patch membrane was excised and the internal aspects of the plasma membrane were exposed to the bath solution, channel activation could be obtained when [Ca2+] i was 10−7 m or above. However, with the passage of time the total inward current declined and about 1 min after excision no unitary current steps could be observed. At this stage Ca2+ in micromolar concentration was needed to open the channels and several hundred micromoles of Ca2+ per liter were required for maximal channel activation. Our results indicate that the Ca2+-activated nonselective cation channel is more sensitive to internal Ca2+ than hitherto understood and that it may therefore play a role under physiological conditions in intact cells.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 28 (1982), S. 73-76 
    ISSN: 1432-0649
    Keywords: 35
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A lithium isotope separation was performed using a laser isotope separation method. It was found that the lithium atoms with a natural isotopic abundance enhanced its6Li concentration up to over 90% by tuning the laser wavelength to the2 P 1/2 of6Li. Too high power, however, leads to a loss of enrichment due to the power broadening effect which was analysed by the equation of motion of density matrices.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 28 (1985), S. 53-59 
    ISSN: 1432-1041
    Keywords: furosemide ; respiratory failure ; furosemide glucuronide ; first-pass metabolism ; diuretic effect ; bioavailability ; food effect ; chronic treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The bioavailability and diuretic effect of furosemide 40 mg administered orally for at least 6 months have been compared in patients with chronic respiratory failure and in healthy controls. The mean urinary recovery of unchanged drug was 11.5 mg and 9.41 mg in 24 h after pre- and postprandial administration to 10 patients, whereas the recovery was 14.4 mg in 10 healthy subjects. The diuretic effect, in terms of urine flow and sodium ion excretion in the 6 h after administration, was also less in patients than in healthy subjects. This was ascribed to the lower bioavailability of furosemide in patients, based on the urinary recovery of unchanged drug, and not to a lower level of response to furosemide than in healthy subjects. The mean absolute bioavailability of furosemide in 6 patients was 41.3% and 63.4%, respectively, calculated from unchanged drug and total drug (unchanged plus glucuronide conjugate). Approximately 53.9% of the dose of furosemide was excreted as the glucuronide conjugate after oral administration, and 34.2% after i.v. injection in the 6 patients. In 3 of the 6 patients studied, a distinct first-pass effect for glucuronidation of furosemide was observed after oral administration. In another study, the mean glucuronide fraction recovered in 24-h urine was 20.7% and 7.3% (p〈0.01) in 38 patients and 12 healthy subjects, respectively. The fraction in urine was not affected by changing the dose of furosemide from 20 to 120 mg. The lower bioavailability in patients as compared to healthy subjects is ascribed to enhanced glucuronidation and incomplete drug absorption.
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  • 4
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cationic antigens have been observed to bind with the negatively charged glomerular basement membrane (GBM). Using the cationic reagent polyethyleneimine (PEI), the distribution of glomerular anionic sites was evaluated ultrastructurally in the early stage (2 h-day 7) of cationic antigen mediated in-situ immune complex formation type glomerulonephritis (GN) in the rat. — Renal perfusion via the renal artery with 100 μg of cationized human IgG (pl〉9.5), followed by the i.v. injection of specific antibodies, led to an initial increase in urinary albumin excretion, subsequent massive globulinuria and the formation of numerous subepithelial deposits on day 7. — The most striking alteration in glomerular anionic sites was observed on the epithelial cell surface coat; the PEI deposition on the epithelial cell surface was almost identical to that in control glomeruli at 2 and 4 h after the induction of GN; thereafter, on day 7, a broad loss of anionic sites was obseryed on flattened epithelial foot processes. In contrast, fixed anionic sites of the laminae rarae of the GBM showed no apparent alterations in the distribution and number from 2 h to day 7 and did not disappear even in the lamina rara externa adjacent to subepithelial deposits. — These findings not only show that fixed anionic sites of the GBM, in contrast to the rapid decrease in those of the epithelial cell surface, are not completely neutralized or destroyed even in GN, in which cationic antigen participates in the in-situ formation of GBM-deposits. This also indicates that initial impairment of the charge-selective barrier of the GBM by the in-situ interaction between cationic antigen and antibody, is followed by the disfunction of the size-selective permselectivity of the GBM, ultimately causing massive proteinuria.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 170 (1993), S. 347-351 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The solutions of carrier-free125mTe(VI) have been prepared by oxidizing125mTe(IV) with bromine. Using carrier-free125mTe(VI) as a tracer, the effects of pH, NaCl concentration, and tellurium(VI) concentration on the adsorption and colloidal properties of tellurium(VI) in NaCl solution have been studied. It has been found that traces of tellurium(VI) are adsorbed on filter paper and show colloidal behavior in the basic region. A method has been devised for the separation of carrier-free125mTe from its parent nuclide125Sb, based on the adsorption properties of125mTe(VI) in basic solutions.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1199-1200 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Interaction between the slow negative-positive waves of human evoked electrospinograms produced by descending and segmental volleys was tested under general anaesthesia. A partial occlusion was demonstrated in these slow waves.
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  • 7
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of tetraethylammonium (TEA) on the action potential in cultured chick embryonic heart muscle cells were investigated. The onset of prolongation of the action potential occurred within 10 min following intracellular iontophoretic application of TEA, but after more than 50 min following extracellular application. These facts suggest that the major site of action of TEA is on the inner surface of the membrane in these cells.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 21 (1983), S. 265-274 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The RBE of Cf-252 neutron irradiation was determined for hemopoietic tissue using spleen CFU-S. Radiosensitivity was compared to acute Cobalt-60 radiation and low dose rate Cesium-137 under identical irradiation conditions. The RBE for the neutron component of the Cf-252 radiation was 2.1. No dose rate effect was observed for hemopoietic CFU-S to acute doses or low dose rate photon irradiation.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 44 (1987), S. 163-166 
    ISSN: 1432-0649
    Keywords: 32.80.Fb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Titanium isotopes were selectively excited and photoionized using a two-step photoionization method, and the isotope separation was demonstrated, in which a separation factor of around 15 for50Ti was obtained. Spectroscopic parameters such as isotope shifts, photo-ionization cross section and excited state lifetimes were also measured. Isotope shifts up to 0.92 GHz were obtained for the transitions between 0 and 19938 cm−1 or between 170 and 20006 cm−1 among five isotopes. The cross section is 7.4×10−17 cm2 for the photo-ionization. The excited state lifetimes are 330±20 ns for 19938 cm−1, 260±15 ns for 20006 cm−1 and 250±15 ns for 20126 cm−1.
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  • 10
    ISSN: 1432-0649
    Keywords: 33
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Energy efficiency has been discussed in the multi-stage laser separation of13C in the ir laser photolysis of CF3I. The comparison has been made between the two methods, i.e., the photolysis of13C molecules (ordinary method) and the photolysis of12C molecules (elimination method). The former recycles the photolyzed product after the regeneration of feed molecules, while the latter recycles the residue after the elimination of the photolyzed product. The analysis of the energy consumption using theoretical models has shown that the elimination method consumes more energy, but the difference is far less than expected; the overall energy consumption may reach the same level at a lower pressure according to our estimation which includes the factors of the quantum efficiency for the dissociation, the energy difference between the laser lines and the material loss for the regeneration. It may imply that the elimination method is more favored in a practical application because it is free from the regeneration procedure.
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