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  • 1
    Electronic Resource
    Electronic Resource
    Changes in sea urchin populations after the destruction of kelp beds (1976)
    Springer
    Marine biology 36 (1976), S. 321-326 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In St. Margaret's Bay, Nova Scotia, Canada, there are large areas in which sea urchins (Strongylocentrotus droebachiensis) have eliminated beds of kelp (Laminaria spp.). Sites were identified where destruction of kelp beds had taken place 1, 2, 3, 3.5 and 4 years ago. With increase of time since kelp disappearance, the sea urchins showed decreased growth rate, reduced gonad size, but an increase in numbers resulting from high recruitment rates in the first two years after kelp bed destruction. These sea urchin populations, by their browsing, effectively prevent the regeneration of kelp. There is, as yet, no evidence of the sea urchin populations being starved out to allow the kelp to return.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389193
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  • 2
    Electronic Resource
    Electronic Resource
    Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 429-434 
    Details
    ISSN: 1432-1041
    Keywords: Atrial natriuretic factor ; Cyclosporin A ; heart transplantation ; renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The mechanism(s) causing high levels of plasma atrial natriuretic factor (ANF) in cardiac allograft recipients is(are) unclear. The kidney is important for the clearance of ANF and renal function may decline with cyclosporin A therapy in these patients. The relationship between plasma ANF level and renal function and also the pharmacokinetics of a continuous infusion of ANF (15.5 ng·kg−1·min−1 for 60 min) was examined in 6 cardiac allograft recipients on cyclosporin A therapy. Resting plasma ANF levels were significantly higher in these patients than in 8 healthy subjects (71 vs. 21 ng·l−1). Both effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were significantly lower in these patients than in healthy subjects (215 vs. 617 ml·min−1 and 55 vs. 102 ml·min−1 respectively). There was a significant inverse correlation between plasma ANF and ERPF (r=-0.86) and between plasma ANF and GFR (r=-0.81). During the period of ANF infusion, steady state plasma ANF levels were significantly higher in cardiac allograft recipients. Total body clearance of ANF was marginally lower in these patients than in healthy subjects (60 vs. 10.0 l·min−1) although this difference did not reach statistical significance. Derived endogenous secretion rate of ANF was threefold higher in patients when compared to healthy subjects (633 vs. 208 ng·min−1). We have therefore shown that cardiac allograft recipients on cyclosporin A have elevated plasma ANF levels and also decreased renal function. Pharmacokinetic analysis have shown that this increase in plasma ANF levels is due more to increased ANF secretion than to decreased ANF clearance in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194330
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of lisinopril on congestive heart failure in normotensive patients with diastolic dysfunction but intact systolic function (1995)
    Springer
    European journal of clinical pharmacology 49 (1995), S. 15-19 
    Details
    ISSN: 1432-1041
    Keywords: Lisinopril ; Diastolic dysfunction ; congestive heart failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract This study examined the effects of lisinopril on diastolic function in 12 normotensive patients (mean age 72 years) with symptomatic congestive heart failure, intact left ventricular systolic function and abnormal diastolic function secondary to ischaemic heart disease in a placebo-controlled double blind crossover study, with each treatment dosed orally for 5 continuous weeks. Compared to placebo, lisinopril significantly decreased blood pressure, increased plasma renin activity without altering heart rate or plasma norepinephrine. There was no statistically significant improvement with lisinopril in radionuclide derived peak filling rate and time to peak filling rate, in Doppler echocardiographic measurements of the ratio of peak flow velocity in early diastole to the peak flow velocity of atrial contraction (E:A ratio) and in visual analogue scales of symptoms. Thus, although angiotension converting enzyme inhibitors may have an established role in the treatment of heart failure secondary to left ventricular systolic dysfunction, its use in patients with isolated diastolic dysfunction remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192352
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 589-591 
    Details
    ISSN: 1432-1041
    Keywords: Atrial natriuretic factor (ANF) ; platelet aggregation ; aldosterone ; whole blood ; ex-vivo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol·kg−1.min−1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6–2 μg·ml−1)-induced or ADP (0.5–2.0 μM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperreactivity, often observed in these conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316102
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  • 5
    Electronic Resource
    Electronic Resource
    TEM investigations of the early stages of TiAl oxidation (1996)
    Springer
    Oxidation of metals 46 (1996), S. 255-285 
    Details
    ISSN: 1573-4889
    Keywords: electron diffraction ; intermetallic ; oxidation ; TEM ; titanium aluminide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The early stages of TiAl oxidation at 900°C and 1000°C in air have been investigated by transmission electron microscopy (TEM). The investigations revealed that at the beginning of oxidation, i.e., after 4 min, TiO2 and Al2O3 grow in a preferential orientation on the γ-TiAl substrate. After 4 h of oxidation an oxide scale structure can already be found similar to that known from long-term oxidation. In addition, besides α-Al2O3, the formation of a second aluminum oxide phase and of titanium nitrides is observed. The processes at the metal-oxide interface of oxidation in the early stages, consisting of a repeated cycle of Al2O3 formation, Al2O3 dissolution, outward migration of Al through the scale, and reprecipitation of Al2O3 in the outer scale, are described by a model. The four stages observed in the kinetics of TiAl oxidation are explained on the basis of the results obtained and the structure of the oxide scale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01050799
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  • 6
    Electronic Resource
    Electronic Resource
    Efficient expression and secretion of Aspergillus niger RH5344 polygalacturonase in Saccharomyces cerevisiae (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 147-156 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract An Aspergillus niger endopolygalacturonase (EC 3.2.1.15) cDNA was expressed in the yeast Saccharomyces cerevisiae. Secretion of the protein into the growth medium was efficiently directed by the fungal leader sequence, and processing occurred at the same site as in Aspergillus. The expression level was significantly enhanced by using a “short” version of the yeast ADHI promoter. An additional increase in the yield of heterologous protein was due to a higher plasmid stability and a rise in plasmid copy number. This was achieved by deleting most of the bacterial sequences from the expression vector. The yeast-derived enzyme showed the same enzymatic and biochemical properties as the fungal polygalacturonase, such as substrate specificity, pH and temperature optima and pI value. The yeast-derived enzyme, however, showed a higher degree of glycosylation and exhibited a more pronounced temperature stability than the fungal enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164494
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  • 7
    Electronic Resource
    Electronic Resource
    Efficient expression and secretion of Aspergillus niger RH5344 polygalacturonase in Saccharomyces cerevisiae (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 147-156 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  An Aspergillus niger endopolygalacturonase (EC 3.2.1.15) cDNA was expressed in the yeast Saccharomyces cerevisiae. Secretion of the protein into the growth medium was efficiently directed by the fungal leader sequence, and processing occurred at the same site as in Aspergillus. The expression level was significantly enhanced by using a “short” version of the yeast ADHI promoter. An additional increase in the yield of heterologous protein was due to a higher plasmid stability and a rise in plasmid copy number. This was achieved by deleting most of the bacterial sequences from the expression vector. The yeast-derived enzyme showed the same enzymatic and biochemical properties as the fungal polygalacturonase, such as substrate specificity, pH and temperature optima and pI value. The yeast-derived enzyme, however, showed a higher degree of glycosylation and exhibited a more pronounced temperature stability than the fungal enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050533
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  • 8
    Electronic Resource
    Electronic Resource
    The theory of quark and gluon interactions (1994)
    Springer
    Few body systems 16 (1994), S. N16 
    Details
    ISSN: 1432-5411
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01077697
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  • 9
    Electronic Resource
    Electronic Resource
    Action dependence of the strong coupling spectrum in lattice gauge theory (1985)
    Springer
    The European physical journal 28 (1985), S. 475-482 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We derive analytic expressions for the meson and baryon propagators in strong coupling 1/N g 2→0 for various modifications of the fermionic action. These interaction terms involve non-nearest neighbour couplings of two types; the spectrum does not improve by including them. The best results are obtained forr≈1/4 of the Wilson-form.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01413611
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  • 10
    Electronic Resource
    Electronic Resource
    Universality of the continuum limit of lattice quantum theories (1984)
    Springer
    The European physical journal 26 (1984), S. 149-155 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The lattice approximation of the naïve continuum action in quantum mechanics or in field theory is not uniquely determined. We investigate to what extent corrections to the lattice action, which vanish in the naïve continuum limit, affect the continuum limit when taking quantum fluctuations into account. In the quantum mechanical case, modifications of the lattice action may induce non-trivial corrections to the potential of the system and thereby change the structure of the theory completely. We verify this statement analytically as well as numerically by performing a Monte Carlo simulation. In the field theoretical case we argue that the lattice corrections considered do not affect the physics of the continuum limit, at least not for asymptotically free gauge field theories. In four dimensions, one might encounter finite renormalization of CP violating terms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01572552
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