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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1165-1172 
    ISSN: 1420-9071
    Keywords: Pharmacology of Parkinson's disease ; antiparkinson drugs ; benserazide ; carbidopa ; L-DOPA ; dopamine receptor agonists ; (−)deprenyl ; MAO-B inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Basic aspects and recent advances in the understanding of the pharmacological mechanism of action of the clinically most used antiparkinson drugs are reviewed. Recent human and animal biochemical investigations clearly confirm and extend previous findings indicating that benserazide is much more potent than carbidopa as peripheral decarboxylase inhibitor. L-DOPA in combination with benserazide or carbidopa constitutes the best available therapy for Parkinson's disease (PD). To reduce peaks and rapid fluctuations of L-DOPA plasma levels (possibly responsible for peak-dose dyskinesias and end-of-dose deterioration) a slow-release formulation of L-DOPA in combination with benserazide or with benserazide plus catechol-O-methyltransferase inhibitors should be developed. In parkinsonian patients under long-term L-DOPA therapy monoamine oxidase inhibitors type B (MAO-B) e.g. (−)-deprenyl and firect dopamine receptor agonists (bromocriptine, lisuride, pergolide etc.), due to their L-DOPA-sparing effects, alleviate in some cases L-DOPA-induced side-effects e.g. dyskinesias and on-off phenomena. However, since (−)-deprenylm, due to its metabolism to (−)methamphetamine and (−)amphetamine, seem to have indirect sympathomimetic activity, new selective MAO-B inhibitors devoid of indirect sympathomimetic effects should be tested clinically to assess the functional role of pure MAO-B inhibition in the therapy of PD. The auxiliary therapy with direct dopmaine receptor agonists of the D-2 subtype represents another valid approach which should be further investigated in order to find novel dopamine agonists, less expensive than bromocriptine and strictly selective for D-2 receptor sites.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 159 (1965), S. 259-270 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 176 (1968), S. 334-341 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Convergence structures (Limitierungen) defined by H. R. Fischer [1] in 1959 anduniform convergence structures (uniforme Limitierungen) introduced by C. H. Cook and H. R. Fischer [2] in 1965 are generalizations of the concepts of topology and uniformity respectively. A convergence structure, induced by some uniform convergence structure, will be called (L)-uniformizable (Limes-uniformisierbar). In this paper a necessary and sufficient condition for (L)-uniformizability of a convergence structure will be given. As a consequence any separated (Hausdorff) convergence structure on a set turns out to be (L)-uniformizable. Also any compatible convergence structure (separated or not) on a group is (L)-uniformizable.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Numerische Mathematik 22 (1974), S. 367-391 
    ISSN: 0945-3245
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We consider difference methods for the solution of singular perturbations of boundary value problems. The solutions are smooth except in boundary layers of thickness ε|logε|, 0〈ε≪1. Various difference schemes with a uniform stepsizeh are considered. In practice,h is usually much larger than the boundary layer regions. Then the difference methods must be choosen with care. It is shown that only approximations of low order accuracy can be used. However, one can increase the accuracy by a Richardson procedure. Asymptotic expansions in powers ofh and ε are given for the solutions of the proposed methods.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1090-6509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Systematic measurements are made of ESR spectra with g ≈ 4.2 in YBa2Cu3O6+y compounds with various doping indices y. Temperature dependences of the spectrum intensity show that the ground states of the centers are singlet and the energies of the excited states M S = ±1 correspond to 8−11 K. In general, the intensity of the ESR spectra varies with time and depends on the sample preparation technology. The most probable models for the paramagnetic centers studied are considered to be chain fragments of copper ions of variable valence. General laws governing the energy structure of these centers are described.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Earth, moon and planets 72 (1996), S. 79-89 
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The icy conglomerate model introduced by Whipple more than 40 years ago has been widely accepted in cometary science because it is able to describe numerous cometary phenomena. In this model comets are described as a conglomerate of ices and dust where the ices represent the major component. However, some recent observations seem to favour dust rich comets. The purpose of this paper is to summarize the observational facts supporting the dominance of refractories in comets and to discuss the consequences of a dust dominated nucleus for cometary physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Earth, moon and planets 72 (1996), S. 103-112 
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Images of comet Halley's nucleus taken by the HMC camera during the GIOT-TO encounter in 1986 show that a major part of the total dust production is localized in a few active areas which are the sources of gas-dust jets. The global dust distribution in the inner coma is dominated by two main jets roughly directed to the sun. A combination of a 1D thermal nucleus model with an axisymmetric continuum model of the jet outflow was used to investigate the properties of the inner coma. Detailed investigations show that the characteristics of the observed jets can be reproduced by outgassing from free sublimating active areas of a few km in diameter, a dust to gas ratio of 1–2.5 and a size distribution dominated by the larger grains. It is further shown that most of the observational constraints provided by the HMC data can be met simultaneously by a model of three jets superimposed on a weak background.
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  • 8
    ISSN: 1573-0794
    Keywords: C/1995 O1 Hale-Bopp ; comets ; infrared spectroscopy ; ISO
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Spectra of comet C/1995 O1 (Hale-Bopp) were obtained with the Infrared Space Observatory (ISO) at medium resolution with the grating spectrometer in the photometer (PHT-S) and/or at high resolution with the short wavelength spectrometer (SWS) and long wavelength spectrometer (LWS) in April 1996 (Crovisier et al., 1996), September–October 1996 (Crovisier et al., 1997a, b) and December 1997, at distances from the Sun of 4.6, 2.9 and 3.9 AU, respectively. For the first time, high-resolution spectra of a comet covering the entire 2.4 to 200 μm spectral range were obtained. The vibrational bands of H2O, CO2 and CO are detected in emission with PHT-S. Relative production rates of 100:22:70 are derived for H2O:CO2:CO at 3 AU pre-perihelion. H2O is observed at high spectral resolution in the ν3 group of bands around 2.7 μm and the ν2 group around 6 μm with SWS, and in several rotational lines in the 100–180 μm region with LWS. The high signal-to-noise ratio of the ν3 band observed on September–October 1996 allows accurate determinations of the water rotational temperature (28 K) and of its ortho-to-para ratio(2.45 ± 0.10, which significantly differs from the high temperature limit and corresponds to a spin temperature of 25 K). Longward of 6 μm the spectrum is dominated by dust thermal continuum emission, upon which broad emission features are superimposed. The wavelengths of the emission peaks correspond to those of Mg-rich crystalline olivine (forsterite). In the September–October 1996 spectra, emission features at 45 and 65 μm and possible absorption at 2.9–3.2 μm suggest that grains of water ice were present at 3 AU from the Sun. The observations made post-perihelion in late December 1997 led to the detections of H2O, CO2 and CO at 3.9 AU from the Sun (Figures 1 and 2). The production rates were ≈3.0 × 1028,3.5 × 1028 and ≈1.5 × 1029 s-1, respectively. This corresponds to H2O:CO2:CO = 100:110:500 and confirms that at such distances from the Sun, cometary activity is dominated by sublimation of CO and CO2 rather than by H2O.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 452-454 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Während einstündiger epiduraler Applikation vo n25% KCl zeigte sich bei Ratten eine Abnahme der elektrischen Aktivität im homolateralen Cortex und Striatum (spreading depression), die nach Entfernung des KCl reversibel war. Mit dem Auftreten von EEG-Veränderungen erfolgte im Gehirn auch ein reversibler Anstieg der Homovanillinsäure, nicht aber des Dopamins (DA), wahrscheinlich als Ausdruck eines gesteigerten DA-Umsatzes. Es wird geschlossen, dass während unilateraler epiduraler KCl-Applikation eine Inaktivierung des homolateralen Striatums besteht, welche möglicherweise durch Desaktivation einer inhibitorischen cortico- und/oder striato-nigralen Bahn zu einer Erhöhung des DA-Umsatzes führt.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1386-1387 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Experiments performed by means of time lapse cinematography or the filter technique show that human serum albumin has marked chemokinetic effects on neutrophil cultured in Gey's solution. The average speed of the cells, as well as the proportion of neutrophils showing locomotion, is increased. Enhanced locomotion correlates with decreased attachment to the substratum as determined by morphological and functional criteria.
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