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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of bioenergetics and biomembranes 29 (1997), S. 3-10 
    ISSN: 1573-6881
    Keywords: Mitochondria ; MCC ; PSC ; import pathway ; membrane channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Mitochondrial biogenesis requires the import of hundreds of different proteins from the cytosol. Protein import into mitochondria is a multistep pathway that includes recognition of precursor proteins by machinery both in the cytoplasm and on the mitochondrial surface, translocation of the precursor across one or both mitochondrial membranes, and folding of the protein after its import into the organelle. Over the past several years, many components of the import machinery have been identified using both biochemical and genetic methods. Recently, significant progress has been made determining the function of some of these import proteins. One purpose of this minireview is to summarize our current understanding of the import pathway, and to introduce the topics of the minireviews that will follow. The other goal of this minireview is to discuss recent findings suggesting that proteins are translocated across both the mitochondrial inner and outer membranes through aqueous channels.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 123 (1993), S. 51-74 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract In this paper we examine the problem of minimizing the sup norm of the gradient of a function with prescribed boundary values. Geometrically, this can be interpreted as finding a minimal Lipschitz extension. Due to the weak convexity of the functional associated to this problem, solutions are generally nonunique. By adopting G. Aronsson's notion of absolutely minimizing we are able to prove uniqueness by characterizing minimizers as the unique solutions of an associated partial differential equation. In fact, we actually prove a weak maximum principle for this partial differential equation, which in some sense is the Euler equation for the minimization problem. This is significantly difficult because the partial differential equation is both fully nonlinear and has very degenerate ellipticity. To overcome this difficulty we use the weak solutions of M. G. Crandall and P.-L. Lions, also known as viscosity solutions, in conjunction with some arguments using integration by parts.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 67 (1977), S. 1-24 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 101 (1988), S. 1-27 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract We prove that viscosity solutions in W 1,∞ of the second order, fully nonlinear, equation F(D 2 u, Du, u) = 0 are unique when (i) F is degenerate elliptic and decreasing in u or (ii) F is uniformly elliptic and nonincreasing in u. We do not assume that F is convex. The method of proof involves constructing nonlinear approximation operators which map viscosity subsolutions and supersolutions onto viscosity subsolutions and supersolutions, respectively. This method is completely different from that used in Lions [8, 9] for second order problems with F convex in D 2 u and from that used by Crandall & Lions [3] and Crandall, Evans & Lions [2] for fully nonlinear first order problems.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 69 (1985), S. 35-48 
    ISSN: 1573-4919
    Keywords: mouse submandibular glands ; nerve growth factor (NGF)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The 7S nerve growth factor molecule, found in the mouse submandibular gland, is comprised of three distinct protein subunits named α, γ and β-NGF. In this paper, radioimmunoassays specific for each subunit were used to measure the concentrations of these subunits in homogenates of mouse submandibular gland. It was determined that there were excess concentrations of both the α and γ subunits, more than enough to bind all of the β-NGF in the gland to form 7S-NGF. The radioimmunoassay data was confirmed by gel filtration experiments. In the gel filtration experiments, the excess α and γ subunits eluted at positions which would indicate that these excess subunits were free and not bound in the 7S-NGF complex. The identity of the excess α and γ subunits was substantiated by ion exchange chromatography, isoelectric focusing polyacrylamide gels and immunoblotting experiments. In conclusion, there are considerable quantities of α and γ subunits present in the submandibular gland which are not bound to β-NGE The functional significance of these excess concentrations of the α and γ subunits is not known.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 86 (1996), S. 187-194 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A device that injects a planar, spike input of tracer and accommodates irregular stream cross-sections was designed and field tested. The injector is based on a modular support and electrical system that can easily be modified in the field. The tracer is distributed to the water from self-emptying packets made of latex tubing. These packets resist premature breakage and contribute no litter to the stream. The packets empty after applying a current to the electrical system. Instream assembly of the tracer injector is possible from a boat. A two-dimensional input of tracer significantly shortens the initial mixing period for streams that are wide and deep. During the initial period, the tracer cloud becomes well-mixed vertically and laterally. After the initial period is satisfied, the variance of the tracer cloud grows linearly with time, and longitudinal dispersion can be measured easily. The use of a plane source injector significantly reduces the duration of the initial period.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The journal of Fourier analysis and applications 2 (1995), S. 237-259 
    ISSN: 1531-5851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Let $L[\,\cdot\,]$ be a nondivergent linear second-order uniformly elliptic partial differential operator defined on functions with domain $\Omega.$ Consider the question, "When is a function u a solution of $L[u] = 0$ on $\Omega$ ?" The naive answer, "u is a solution of $L[u] = 0$ on $\Omega$ if $u\in C^2(\Omega)$ and $L[u](x) = 0$ for all $x\in\Omega,$ " is clearly too limited. Indeed, if the coefficients of L are in $W^{1,2}\cap L^{\infty},$ then L can be rewritten in divergence form for which the notion of a "weak" solution can be applied. In this case there could be infinitely many functions that are "weak" but not classical solutions. More importantly, even if the coefficients of L are just bounded and measurable, the recent results of Krylov permit us to construct "solutions" of $L[u] = 0$ on $\Omega,$ and these "solutions" are generally no better than continuous; the "weak" solutions previously mentioned can be obtained by this construction, too. The preceding discussion provides us with an adequate extrinsic definition of solution (i.e., given a function u we either prove that it is or is not the result of such a construction) that has been used by several authors, but one that is not particularly satisfying or illuminating. Our major contribution in this paper is to show the following. I. There is an intrinsic definition of solution that is equivalent to the extrinsic one. II. Furthermore, the intrinsic definition is just the (now) well-known Crandall-Lions viscosity solution, modified in a natural way to accommodate measurable coefficients.
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  • 8
    ISSN: 1432-0878
    Keywords: Nerve growth factor ; Submandibular gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary For unexplained reasons, nerve growth factor (NGF) exists in very high concentrations in the submandibular gland of the mouse. The NGF in the gland, called 7S-NGF, is a non-covalent complex of three protein subunits, named α-, γ- and β-NGF. All the known biological activity resides in the β-NGF subunit, and previous studies have shown that β-NGF is present in much greater concentrations in the male submandibular gland than in the female gland. The higher concentration in the male is due to the fact that β-NGF is synthesized in the granular tubule cells of the submandibular gland. These cells are much more numerous in the male gland. In contrast to β-NGF, neither the concentrations of α and γ subunits nor their cellular localization in the mouse submandibular gland have been established. In this study, radioimmunoassays specific for α. and γ subunits determined that both are present in much higher concentrations in the male gland. Immunocytochemical work localized both subunits in the granular tubule cell in the male and female submandibular gland. This indicates that all the components of 7S-NGF exist in a single cell type in the gland and suggests that 7S-NGF can be formed within this cell and secreted as a complex into the saliva.
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  • 9
    Publication Date: 1985-11-01
    Print ISSN: 0300-8177
    Electronic ISSN: 1573-4919
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 10
    Publication Date: 1985-01-01
    Print ISSN: 0024-4201
    Electronic ISSN: 1558-9307
    Topics: Biology , Chemistry and Pharmacology
    Published by Springer
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