ISSN:
1572-9931
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract An irradiation-reduced somatic cell hybrid mapping panel was constructed of BALB/c mouse Chromosome 1. Nineteen hybrids were selected from a pool of 292 clones to generate a fine structure physical map of the distal 40 cM of the chromosome. The hybrids contain mouse DNA fragments only from Chromosome 1, ranging from ∼5 cM to ∼20 cM. Utilizing a viral infectibility assay, a cellular receptor gene,Rmc-1, for the MCF class of murine retroviruses was found to be linked toLamb2, in the region between theLamb2 andBxv-1 loci. In addition, analysis of the hybrid mapping panel resulted in the remapping of three loci,Atpb, Ly-5, andPmv-24, as compared to the mouse linkage map. Two previously unmapped endogenous proviruses are also putatively assigned positions on the chromosome.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01232974
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