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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 60 (1997), S. 567 -570 
    ISSN: 1432-0827
    Keywords: Key words: Colles' fracture — Calcitonin — Calcium — Radiogrammetry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. In 45 women with Colles' fracture, two types of complementary medical treatment (calcitonin with calcium [SCT+Ca] and calcium alone [Ca]) were compared with placebo. Consecutive patients were assigned randomly to one of the three study groups at the time of inclusion in the study: 15 women (68.6 ± 5.7 years) were given 100 IU/day I.M. of SCT plus 1200 mg of elemental Ca for 10 successive days each month; 15 women (71.7 ± 6.1 years) were given only 1200 mg of elemental Ca for 10 days each month; and 15 women (66.9 ± 7.9 years) were treated with placebo. Biochemical and radiogrammetric studies were made at baseline and after 1 year of treatment. In the SCT+Ca group tartrate-resistant acid phosphatase decreased (Wilcoxon test, P= 0.014) and the metacarpal index and the cortical and total area (CA/TA) ratio increased (both P= 0.001). In the group treated with Ca alone, no changes were observed. In the placebo group, the metacarpal index and CA/TA decreased (P= 0.015 and P= 0.007, respectively). Ca alone, at the dosage used here, inhibited bone loss after Colles' fracture. The addition of SCT to Ca administration not only impeded bone loss but significantly increased cortical bone mass.
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  • 2
    ISSN: 1432-0827
    Keywords: Key words: Colles' fracture — Osteoporotic fractures — Type I osteoporosis — Postmenopausal women — Corticoendosteal bone loss.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Based on the hypothesis that the underlying osteoporotic mechanism of Colles' fracture in postmenopausal women is similar to that of other osteoporotic fractures, that is, cortical bone resorption as opposed to cancellous bone resorption, the rate of corticoendosteal bone loss was compared in 40 normal postmenopausal women [average age 68.4 ± 7.1 years; 20 ± 4 years since menopause (YSM)], in 35 postmenopausal women with Colles' fracture (age 69.4 ± 7.5 years, 22 ± 8 YSM), in 35 normal postmenopausal women with vertebral crush fracture (age 69.4 ± 7.5 years, 22 ± 8 YSM, and in 35 normal premenopausal women (age 36.1 ± 7.9 years). Radiogrammetry by digital radiography of the second metacarpal was used to measure external (ED) and internal (ID) diameter, cortical thickness (CCT), cortical area (CA), and the ratio of cortical area to total area (CA/TA). The ID values of the groups of postmenopausal women were subtracted from the ID value of the premenopausal women and the result was divided by YSM to obtain the rate of corticoendosteal resorption/year (ΔC), CA resorption year (ΔCA) and CA/TA resorption/year (ΔCA/TA). ID, ΔC, ΔCA, and ΔCA/TA all were larger in the postmenopausal women with Colles' and vertebral crush fractures than in the normal postmenopausal women (ANOVA: all P 〈 0.0001). ID, CCT, ΔC, CA, ΔCA, and ΔCA/TA did not differ between the two groups of postmenopausal women with fractures. ΔC was 87% greater in postmenopausal women with vertebral crush fracture and 116% greater in women with Colles' fracture than in normal postmenopausal women. These results indicate that the loss of cortical bone is an important factor in Colles' fracture in postmenopausal women.
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  • 3
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The surface morphology of the gill epithelium of the dogfish Scyliorhinus canicula L. (collected near Barcelona, Spain, in February–March, 1981) was studied by scanning electron microscopy. Pavement cells exhibited either surface microvilli or microridges, which were randomly distributed on both the primary (afferent and efferent sides and interlamellar spaces) and secondary epithelium. Chloride cell apical regions on the afferent side displayed characteristics closer to freshwater than to marine teleosts: no apical pits were detected; chloride cells displayed longer microvilli than those of adjacent cells. Two morphologically different cell types were identified: a large chloride cell and a smaller cell (probably a chloride cell too), measuring 4 to 7 μm and 1 μm, respectively, the latter being dominant in the interlamellar spaces. Apart from pavement cells, the mucous cell was the prevalent cell type on the efferent region. The respiratory epithelium consisted of a mozaic of typical epithelial cells; some chloride and mucous cells were present, mainly located at the base of the secondary lamellae. Surface morphological changes were monitored after exposing the dogfish to subacute zinc treatment: 10 ppm Zn (ZnSO4) for 3 wk. The chloride cell was the only cell type that underwent any modifications: microvilli became longer and tips were swollen following Zn treatment. The results are discussed in relation to a previous study on the effects of zinc sulphate on chloride cell response and heavy metal distribution in excretory organs of the dogfish.
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  • 4
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Zinc and copper levels in the gills, kidney and intestine of the dogfish Scyliorhinus canicula L. collected in a 80 to 120 m deep zone close to Barcelona (Spain) during the months of February–March 1981 were measured by atomic absorption spectrophotometry after subacute (10 ppm Zn for 3 wk) and acute (80 ppm Zn for 24 h) treatment with ZnSO4. Individuals exposed to 80 ppm Zn accumulated Zn in the gills, whereas no significant increase in Zn content was found in the kidney or intestine. No differences in the Cu content of any of these tissues were found. Dogfish exposed to 10 ppm Zn for 3 wk displayed an increase in Zn content of the gills, kidney and intestine. An increase in the Cu concentration of the gills was also recorded which may suggest that Cu, and hence Zn and other heavy metals, are excreted via the gills when the kidney and intestine are overloaded. A light-microscopic study of the gill epithelium was carried out on dogfish treated with 10 ppm Zn for 3 wk, 80 ppm Zn for 24 h and 175 ppm Zn for 14 h, and chloride cell response was quantified. Chloride cells increased in number after each treatment, even appearing in the secondary lamellae following treatment with 175 ppm Zn. It is suggested that the chloride cell may excrete bivalent ions when dogfish are exposed to an excess of bivalent salts.
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  • 5
    ISSN: 1432-0630
    Keywords: 61.80.-x ; 68.35.Rh ; 81.40.-z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract During 350 keV Ar+ irradiation at 77K, laser-deposited Fe−Ag multilayers first show stress relaxation and demixing processes at the interfaces followed by grain coarsening and a supersaturation of the bcc α-Fe phase with Ag due to ballistic mixing. At high fluence, the fcc γ-Fe(Ag) phase (a=3.65 Å) is formed, which can be explained by either chemically guided ballistic short-range relocations or by the occurrence of thermal spikes, where all atoms possess sufficient energy to allow collective structural rearrangements, but only during such a short time that a decomposition due to long-range diffusion is suppressed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 23 (1982), S. 155-160 
    ISSN: 1432-1041
    Keywords: amikacin ; pharmacokinetics ; development ; neonate ; infant ; child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition kinetics of a single i.v. dose of amikacin was studied in 6 neonates (6–25 days old), 10 infants (4–18 months) and 8 young children (3–11 years). There was a progressive change in the distribution and elimination kinetics during development. The distribution coefficient of the antibiotic averaged of 0.429, 0.320 and 0.210 l/kg in the newborns, infants and young children, respectively and serum half-life (t1/2 β) in these three groups averaged 2.812, 1.803 and 1.196 h, respectively. Significant differences in certain pharmacokinetic parameters were found between the values in paediatric patients and in adults receiving the same dose. A linear relationship was established between the distribution volume of the antibiotic and the weight of the patients, as defined by the following equation: $${\text{Vd}}_{{\text{ss}}} \left( 1 \right) = 0.976 + 1.140 \cdot {\text{TBW}}\left( {{\text{kg}}} \right);r = 0.954$$ The results suggest that a regimen of very frequent administrations should be employed in infants and young children in order to maintain a therapeutic level throughout treatment.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 59 (1997), S. 757-762 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 80 (1991), S. 691-702 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract The Ossa-Morena Zone (OMZ) and the Southportuguese Zone (SPZ) represent the southernmost domains of the Iberian Massif (European Hercynian Belt). Lithostratigraphic, pétrographic and structural differences exist between both zones. The boundary between the OMZ and the SPZ is marked by a narrow belt of amphibolites of tholeiitic oceanic affinity (Bard &Moine, 1979);Munha et al., 1986), and associated serpentinites, flaser gabbros, pillowed metabasalts (Castro et al., 1987) which are highly sheared along their southern border. These Beja-Acebuches ophiolites (op. cit.) are exposed for over 200 km. In the southernmost part of the OMZ and the northernmost area of the SPZ, several zones have been distinguished on the basis of structural and lithological criteria. The southernmost area of the OMZ which bounds the Acebuches amphibolites, is composed of high grade metamorphic rocks and an another important shear zone mark the OMZ northern boundary. The boundary between the OMZ and the SPZ is considered to be a suture zone between two continental areas represented by the northern OMZ and the southern SPZ. Sinistral transpression associated with large scale recumbent folds are characteristic of the suture, which can be tentatively correlated through the Ibero-Armorican arc with the Lizard complex (SW England).
    Abstract: Resumen La Zona de Ossa-Morena (OMZ) y la Zona Surportuguesa (SPZ) representan los dominios más meridionales del Macizo Ibérico (Cadena hercínica europea). Las diferencias entre ambos dominios son de naturaleza litoestratográfica, petrográfica y estructural. El contacto entre ambas zonas (OMZ y SPZ) está subrayado por una estrecha banda de anfibolitas (»de Acebuches«,Bard, 1969) y rocas asociadas (serpentinitas, flaser gabbros, metabasaltos en pillow,Castro et al., 1987), que se pueden seguir de manera contínua, a lo largo de más de 200 km. Estas anfibolitas tienen afinidades de toleitas oceánicas (Bard &Moine, 1979;Munha et al., 1986) y representan restas de una secuencia ofiolitica (op. cit.). Hacía el sur, están afectadas por un intenso cizallamiento. En la parte meridional de la OMZ y en el sector más septentrional de la SPZ se han diferenciado una serie de zonas en función de sus características litológicas y estructurales. El sector más meridional de la OMZ, directamente en contacto con las anfibolitas de Acebuches, esta constituido por rocas metamórficas de alto grado y esta limitado al N y al S por importantes zonas de cizalla. El contacto entre la OMZ y la SPZ debe ser considerado como una zona de sutura entre dos areas continentales, representadas respectivamente por la OMZ al norte (en su posición actual) y la SPZ, al sur. Una convergencia de tipo transpresiva sinistrorsa, con grandes pliegues recumbentes vergentes hacía el sur, caracteriza esta sutura, que puede correlacionarse con el macizo de Lizard (SW de Inglaterra), a través del arco Ibero-Armoricano.
    Notes: Zusammenfassung Die Ossa-Morena Zone (OMZ) und die Südportugiesische Zone (SPZ) bauen die südlichsten Anteile des Iberischen Massivs auf (europäisches Variszikum). Sie unterscheiden sich auf lithostratigraphischer, petrographischer und struktureller Basis. Die Grenze zwischen OMZ und SPZ wird vom schmalen Streifen der Acebuches-Amphiboliten gebildet, Meta-Ophiliten tholeiitisch-ozeanischer Prägung (Bard &Moine, 1979;Munha et al. 1986). Sie lassen sich über mehr als 200 km verfolgen. Eine intensive Scherung überprägt sie im Süden. Eine Unterteilung des Südrandes der OMZ und des Nordrandes der SPZ konnte mittels struktureller und lithologischer Kriterien durchgeführt werden. Der südlichste Abschnitt der OMZ längs der Acebuches-Amphibolite, besteht aus hochgradig metamorphen Gesteinen; er ist gegen Norden durch eine weitere, größere Scherzone begrenzt. Die Grenze zwischen OMZ und SPZ muß somit als eine Sutur-Zone zwischen zwei kontinentalen Blöcken betrachtet werden, der OMZ im Norden (heutige Position) und der SPZ im Süden. Diese Sutur wird von einer sinistral transpressiven Konvergenz-Zone mit großräumig liegenden Falten überprägt. Sie kann durch den Ibero-Armorikanischer Bogen mit dem Lizard-Komplex in SW-England korreliert werden.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 13 (1994), S. 63-69 
    ISSN: 1476-5535
    Keywords: Flocculation ; Fluidized bed reactor ; Lactic starter cultures ; Lactobacillus plantarum ; Viability ; Dilution rate ; Bleed rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The influence of different operational parameters, such as the dilution rate (D) and the bleeding rate (B), in the production of a flocculent strain ofLactobacillus plantarum was studied. The effect of the dilution rate was demonstrated to be related to the lactic acid concentration inside the reactor. The effect of the bleeding rate was shown to be critical in the stabilization of the operation (due to a better pH control). It also allowed a continuous recovery of cells outside the reactor. Viability testing of the lactic starter cultures showed that operation with cell purge increased the viability of the starter cultures obtained.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mathematical sciences 39 (1987), S. 2610-2624 
    ISSN: 1573-8795
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Under natural assumptions about the model and the convergence of the sequence of observation plans, we prove consistency and strong asymptotic normality of the estimator vector.
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