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  • 1
    Electronic Resource
    Electronic Resource
    Hb Costa Rica or α2β277(EF1)His→Arg: The first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 829-833 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a minor hemoglobin component (∼5%) in the blood of a healthy Costa Rican female, but not in her mother and two brothers (father not studied), that has an His→Arg replacement at position β77 (Hb Costa Rica). No other amino acid replacements were observed and no β- or γ-chain-like peptides were present. Hb Costa Rica has a normal stability. Sequence analyses of numerous polymerase chain reaction (PCR)-amplified segments of DNA that contain exon 2 of the β gene failed to identify a CAC→WGC (His→Arg) mutation. The same was the case when cDNA was sequenced, indicating that a β-Costa Rica-mRNA could not be detected with this procedure. Gene mapping of genomic DNA withBglII,BamHI, andHindIII gave normal fragments only and with the same intensity as observed for the fragments of a normal control. The quantities of the β chain variants Hb JIran and Hb Fukuyama with related mutations at (β77 vary between 30% and 45% in heterozygotes, whereas that of Hb F-Kennestone with the same His→Arg mutation but in theGyγ-globin gene, is a high 40%–45% (as percentage of totalGγ) in a heterozygous newborn. These different observations exclude a heterozygosity of the A→G mutation at codon β77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a β-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica. Allele-specific amplification of cDNA with appropriate primers identified the presence of a low level of mutated mRNA in the reticulocytes of the patient, which was confirmed by dotblot analysis of the same material with32p-labeled probes. Comparable amplification products were not observed in genomic DNA. The A→G mutation apparently occurred in a somatic cell at a relatively early stage in the development of the hematopoietic cell system, and Hb Costa Rica accumulated through rapid cell divisions in patchy areas in the bone marrow (somatic mosaicism). An unequal distribution of Hb Costa Rica over the red cells supports this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346198
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  • 2
    Electronic Resource
    Electronic Resource
    Hb Costa Rica or · 2 ‚ 277(EF1)His→Arg: the first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 829-833 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a minor hemoglobin component (∼5%) in the blood of a healthy Costa Rican female, but not in her mother and two brothers (father not studied), that has an His→Arg replacement at position β77 (Hb Costa Rica). No other amino acid replacements were observed and no β- or γ-chain-like peptides were present. Hb Costa Rica has a normal stability. Sequence analyses of numerous polymerase chain reaction (PCR)-amplified segments of DNA that contain exon 2 of the β gene failed to identify a CAC→CGC (His→Arg) mutation. The same was the case when cDNA was sequenced, indicating that a β-Costa Rica-mRNA could not be detected with this procedure. Gene mapping of genomic DNA with BglII, BamHI, and HindIII gave normal fragments only and with the same intensity as observed for the fragments of a normal control. The quantities of the β chain variants Hb J-Iran and Hb Fukuyama with related mutations at β77 vary between 30% and 45% in heterozygotes, whereas that of Hb F-Kennestone with the same His→Arg mutation but in the Gγ-globin gene, is a high 40%–45% (as percentage of total Gγ) in a heterozygous newborn. These different observations exclude a heterozygosity of the A→G mutation at codon β77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a β-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica. Allele-specific amplification of cDNA with appropriate primers identified the presence of a low level of mutated mRNA in the reticulocytes of the patient, which was confirmed by dotblot analysis of the same material with 32P-labeled probes. Comparable amplification products were not observed in genomic DNA. The A→G mutation apparently occurred in a somatic cell at a relatively early stage in the development of the hematopoietic cell system, and Hb Costa Rica accumulated through rapid cell divisions in patchy areas in the bone marrow (somatic mosaicism). An unequal distribution of Hb Costa Rica over the red cells supports this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050145
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  • 3
    Electronic Resource
    Electronic Resource
    The influence of uremia on the accessibility of phosphomycin into interstitial tissue fluid (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 333-338 
    Details
    ISSN: 1432-1041
    Keywords: phosphomycin ; pharmacokinetics ; impaired renal function ; “skin blister” ; interstitial fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The entry and persistence of phosphomycin in interstitial tissue fluid (ITF) were studied in 9 patients with normal renal function and 8 patients with varying degrees of renal impairment, all of whom received a single i.v. dose of 30 mg/kg. ITF was obtained from skin blisters produced by suction. The antibiotic followed a two-compartment open kinetic model. In patients with normal renal function, phosphomycin is incorporated rapidly into the ITF reaching a level of 60.4 µg/ml 60 min after administration. There was no statistically significant difference between the elimination rates from serum and ITF. The serum half-life of the slow disposition phase was 1.75 h in patients with normal renal function. There was a linear correlation between the elimination half-life of phosphomycin in serum and ITF in subjects with differing degrees of renal impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01037944
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  • 4
    Electronic Resource
    Electronic Resource
    Gm and Km frequencies in a Portugese population (1982)
    Springer
    Human genetics 〈Berlin〉 61 (1982), S. 154-156 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Serum samples from 79 healthy subjects and 31 patients with type I amyloid neuropathy were typed for nine Gm markers. No significant associations were found between any of the Gm phenotypes and the disease. The frequencies of the various phenotypes showed satisfactory agreement with the Hardy-Weinberg distribution. One individual had an unusual Gm phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274207
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  • 5
    Electronic Resource
    Electronic Resource
    Poly(vinyl alcohol)-nalidixic acid adducts (1995)
    Springer
    Polymer bulletin 35 (1995), S. 533-537 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary This work deals with the coupling of nalidixic acid (NAL) to poly (vinyl alcohol) (PVAL) functionalized with chloroacetate groups by reaction with its potassium salt. The structure of the resulting adducts was determined by means of 1H and 13C NMR spectroscopy. The obtained results show the reaction to occur in a quantitative way. The hydrolysis in the heterogeneous phase of PVAL-NAL adducts showed that the release of the bioactive compound is dependent on the hydrophilic character of the adduct as well as on the pH value of the medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324105
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  • 6
    Electronic Resource
    Electronic Resource
    On Two Parameter Envelopes of n-Spheres in a Real Spaces Form (1999)
    Springer
    Geometriae dedicata 75 (1999), S. 301-316 
    Details
    ISSN: 1572-9168
    Keywords: hypersurfaces ; envelopes of shperes ; Weingarten relations ; mean curvature ; focal surfaces.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this work we are mainly concerned with the study of special 2-parameter envelopes M n (n≥ 4) of n-spheres in a simply connected space form Q c n+1 (c = 0, 1 or −1) which satisfy the Weingarten relation A + BH + CK = 0 between the mean curvature H and the Gauss–Kronecker curvature K of the immersion x : M n → Q c n+1 , where A, B and C are real constants; such a relation includes the case H constant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005171620545
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  • 7
    Electronic Resource
    Electronic Resource
    Electrical resistivity in ferromagnetic NiCu alloys near the Curie point (1975)
    Springer
    Journal of low temperature physics 18 (1975), S. 125-137 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Direct measurements of the temperature derivative of the electrical resistivity dϱ/dT have been made on several ferromagnetic NiCu alloys with high Cu content (20, 30, 40, 50.4 at %). For Ni80Cu20 and Ni70Cu30 the results closely resemble the general pattern found in pure ferromagnets: dϱ/dT ∼- b − a ln ¦ɛ¦, for 10−3 ≲ ¦ɛ¦ ≲ 10−1, with a and b constants and ɛ = (T/T c )− 1. In Ni60Cu40 the rounding off of the magnetic transition is already so pronounced that a similar analysis is hardly significant. In the Ni49.6Cu50.4 sample negative values of dϱ/dT were confirmed above ~165 K. The possible theoretical implications of the results are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00116974
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  • 8
    Electronic Resource
    Electronic Resource
    Selection Method and Characterization of Neutron Monochromator Natural Crystals (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 245 (2000), S. 475-483 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Thermal neutrons are important analytical tools for microscopic material probe. These neutrons can be selected by diffraction technique using monocrystal, usually artificial. A crystal selection process was implemented and the characteristics of natural specimens were studied by activation analysis-k 0 method. The representative 120 samples, of which 21 best types, were irradiated in IPR-R1 and measured with a neutron diffractometer at IEA-R1m Brazilian reactors. These results are useful for database build up and ease the choice of appropriate natural crystal, with some advantage options: highest intensity diffracted, enlarging the energy operational interval and optimal performance in special applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006732521005
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  • 9
    Electronic Resource
    Electronic Resource
    Antibody response inPlasmodium vinckei malaria after treatment with chloroquine and adjuvant interferon-γ (1992)
    Springer
    Parasitology research 78 (1992), S. 629-634 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The antibody response of mice infected withPlasmodium vinckei after treatment with chloroquine either alone or in combination with interferon-γ (IFN-γ) was determined. Sequential serum samples were drawn from BALB/c mice receiving either 240 μg chloroquine on the day of infection or 120 μg chloroquine plus 104 units IFN-γ daily for 11 days beginning on day 3 prior to infection. Mice treated with additional IFN-γ showed an early induction of IgG2a response and a reduction in IgG1 antibodies as detected by the immunofluorescence technique at between 10 and 16 days after infection as compared with mice treated with chloroquine alone. Thus, IFN-γ may partly exert its antimalarial activity via the induction of IgG2a antibody formation. At 4–6 weeks after infection, when mice from both groups resisted homologous re-infection, the predominant antibody isotypes found in both groups were IgG1 and IgG2a. Serum samples obtained from mice in both treatment groups at 6 weeks after infection were used for serum transfer experiments. When parasitised erythrocytes were preincubated with such immune serum, a retardation of the course of parasitaemia by 2 days was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931511
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  • 10
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    Physiological and biochemical responses to low non-freezing temperature of two Eucalyptus globulus clones differing in drought resistance (2008)
    Springer
    Details
    Publication Date: 2008-01-01
    Print ISSN: 1286-4560
    Electronic ISSN: 1297-966X
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Springer
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