ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    About the Efficiency of Numerical 1-D and 2-D Modelling of Site Effects in Basin Structures (2000)
    Springer
    Pure and applied geophysics 157 (2000), S. 319-342 
    Details
    ISSN: 1420-9136
    Keywords: Key Words: Site effects, seismic hazard analysis, numerical 1-D and 2-D modelling, reflectivity method, Aki-Larner method, finite difference modelling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —In the present study we compare results obtained from experimental estimates of local site amplification effects with those from numerical modelling using four different techniques. We benefit from an extremely precise knowledge of the near-surface structure and experimental estimates of the local amplification factors which are determined from seismic weak-motion data recorded by a dense array across a sedimentary basin at a European test-site in Northern Greece. The possibilities and limitations of the different modelling techniques (a 1-D technique, and three 2-D techniques) to model the effects of local amplification effects are tested. Amplifications calculated by the numerical techniques are only qualitatively compared with observed data from experimental studies in the time domain and directly in the frequency domain.¶As a result we conclude that, in the case of a complex subsurface geometry, 1-D modelling underestimates the amplification patterns in terms of absolute amplification level, and cannot correctly account for resonant frequencies, at least for modes higher than the fundamental mode. If a more realistic incident wave field than just a plane wave is taken into account, 2-D modelling reveals the fundamental frequency and shows adequate amplifications not only at the fundamental frequency but also at higher frequencies. The general trend of the amplifications at the lowest frequencies is well determined by the 2-D numerical modelling, and can therefore supply information for seismic risk analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000240050002
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A traction-based mechanism for somitogenesis in the chick (1988)
    Springer
    Development genes and evolution 197 (1988), S. 513-517 
    Details
    ISSN: 1432-041X
    Keywords: Cell adhesion ; Condensation ; Mechanism ; Somitogenesis ; Traction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary This paper suggests that chick somites form because presomitic cells exert tractional forces on one another. These forces derive from the increase in cell adhesion and density that occurs as N-CAM and N-cadherin are laid down by the motile cells of the presomitic mesoderm, well before the somites form. Harris et al. (1984) have shown that adhesive and motile cells in an appropriate environment in vitro can spontaneously form aggregates under the influence of the tractional forces that they exert. Presomitic mesodermal cells may behave similarly: as CAM production increases local adhesivity, the tractional forces between the cells should become sufficiently strong for groups of cells to segment off the mesenchyme as somites. The successive expression of CAMs down the presomitic mesoderm will thus lead to the formation of an anterior-posterior sequence of somites. This mechanism can explain several aspects of somitogenesis that models generating a repetitive pre-pattern through gating cohorts of cells find hard to explain: first, mesodermal segregation occurs among highly adherent cells; second, that multiple rows of somites can form in embryos cultured on highly adherent substrata; third, that stirred mesoderm will still form normal somites; and, fourth, how somite size can be altered in heat-shocked embryos and elsewhere. Suggestions are given as to how the mechanism may be tested and where else in the embryo it could apply.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00385686
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    One-dimensional λ-ω target patterns: Empirical stability tests (1980)
    Springer
    Journal of mathematical biology 10 (1980), S. 97-100 
    Details
    ISSN: 1432-1416
    Keywords: Reaction diffusion equations ; Wave-trains ; Stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Summary Stability of a class of solutions to reaction-diffusion equations is studied numerically. It is found that the solutions do not persist under a variety of boundary conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276399
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Selecting a common direction (1996)
    Springer
    Journal of mathematical biology 34 (1996), S. 811-842 
    Details
    ISSN: 1432-1416
    Keywords: Orientation selection ; Total alignment ; Peak ansatz ; Parallel cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The problem of alignment of cells (or other objects) that interact in an angle-dependent way was described in Mogilner and Edelstein-Keshet (1995). In this sequel we consider in detail a special limiting case of nearly complete alignment. This occurs when the rotational diffusion of individual objects becomes very slow. In this case, the motion of the objects is essentially deterministic, and the individuals or objects tend to gather in clusters at various orientations. (Numerical solutions show that the angular distribution develops sharp peaks at various discrete orientations.) To understand the behaviour of the deterministic models with analytic tools, we represent the distribution as a number of δ-like peaks. This approximation of a true solution by a set of (infinitely sharp) peaks will be referred to as thepeak ansatz. For weak but nonzero angular diffusion, the peaks are smoothed out. The analysis of this case leads to a singular perturbation problem which we investigate. We briefly discuss other applications of similar techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834821
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    A distinctive change in odortype determined by H-2D/L mutation (1991)
    Springer
    Immunogenetics 34 (1991), S. 129-131 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00211425
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Fetal H-2 odortypes are evident in the urine of pregnant female mice (1994)
    Springer
    Immunogenetics 39 (1994), S. 109-113 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The major histocompatibility complex (MHC) imparts to each mouse an individual urinary odor, called “odortype”, which reflects its MHC genotype. Perception of odortypes affects mate selection and embryonic implantation. Recent findings that odortypes tre expressed as early as one day of age suggested that they might already be expressed in utero. We now report that at 9–12 days of gestation, odortypes specified by paternal (non-maternal) MHC haplotypes become apparent in maternal urine. Thus, odortypes are expressed in utero, can be sensed even before birth, and may serve in familial identification and communication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00188613
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Effect of B2m gene disruption on MHC-determined odortypes (2000)
    Springer
    Immunogenetics 51 (2000), S. 514-518 
    Details
    ISSN: 1432-1211
    Keywords: Key words Odortype ; Behavior ; Knockout ; MHC ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Major histocompatibility complex (MHC) genes confer individual olfactory identity that can be detected with exquisite accuracy by mice. The fact that MHC genes themselves generate the characteristic odortype, rather than dedicated odor-determining genes, was supported in studies of point mutations in H2K and HLA transgenic mice, which evinced distinct odor profiles in olfactory assays. In this article we provide further evidence for a central role of MHC genes themselves in odortype specification by demonstrating that mice that are unable to express their genomic class I MHC genes because they lack β2-microglobulin are distinguishable by scent from otherwise identical mice which possess an intact B2m gene. This odortype disparity appears at 9–12 days of gestational age, the period in which the MHC is first detectable in fetal cells of normal mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510000165
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Polymorphisms of the apolipoprotein B and E genes and their relationship to plasma lipid variables in healthy Chinese men (1993)
    Springer
    Human genetics 〈Berlin〉 92 (1993), S. 191-197 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this study we have analysed the apolipoprotein (Apo) E polymorphism and polymorphisms of the ApoB gene, including the ApoB/Xba I and ApoB/4311 diallelic polymorphisms and a hypervariable region (HVR) situated in the 3′ region of the gene (ApoB/3′HVR), in a sample of healthy male subjects from Taiyuan (northern People's Republic of China). In comparison to Caucasian populations, in the Chinese sample, the Xba I2 allele (presence of cutting site; frequency 6.1%; and 95% confidence interval, 3.3–8.9) and the long HVR alleles (9.4%; 6.0–12.8) were rare, whereas the ApoB/4311 (Ser) allele (70.8%; 65.4–76.2) and the 34-repeat allele of the HVR (HVR34; 62.4%; 56.8–68.0) were frequent. In subjects having none, one, or two HVR34 alleles, the mean levels of plasma triglycerides were 2.32±1.44 (SD), 1.45+0.74, and 1.75±1.07 g/l, respectively (P 〈 0.007). Similar trends were observed for very low density lipoprotein (VLDL) cholesterol, LpE:B, and LpCIII:B. The frequencies of the ApoE alleles were similar to those reported in other populations of Asian origin; E2 (7.4%; 4.2–10.6), E3 (84.4%; 80.2–88.6), and E4 (8.2%; 5.0–11.4). Individuals carrying the E2 allele had a lower mean level of ApoB than E33 individuals: 0.87±0.16 and 1.00±0.22 g/l, respectively (P 〈 0.007). Individuals carrying the E4 allele had higher levels of ApoE than E33 individuals: 0.140±0.084 and 0.094±0.052 g/l, respectively (P 〈 0.004); similar trends were observed for VLDL cholesterol, triglycerides, LpE:B, and LpCIII:B. The ApoB/ HVR34 and ApoE/E4 polymorphisms accounted for 10% to 15% of the variability of the plasma levels of VLDL cholesterol, ApoE, triglycerides, LpE:B, and LpCIII:B. Several lipid variables appeared to be favourably affected by specific forms of ApoB and ApoE that are particularly frequent in this Chinese population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219691
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 545-550 
    Details
    ISSN: 1432-1041
    Keywords: simvastatin ; hypercholesterolaemia ; HMG-CoA reductase inhibitor ; cholesterol ; apolipoproteins ; lipoprotein particles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of treatment with simvastatin, a new HMG-CoA reductase inhibitor, has been investigated in 27 patients with primary hypercholesterolaemia. It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoproteins B, C-III and E were also significantly lowered. The concentration of lipoprotein particles recognized by monoclonal antibodies (BL3, BL5 and BL7), associated with atherosclerotic disease, was also lowered by the treatment. Lipoproteins LpA-II:A-I were not changed, while LpA-I, which has been suggested to be the protective fraction of the apo A-I-containing lipoproteins, was slightly and inconsistently increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562541
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Efficacy and safety of high dose fluvastatin in patients with familial hypercholesterolaemia (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 513-518 
    Details
    ISSN: 1432-1041
    Keywords: Hypercholesterolaemia ; Fluvastatin ; molecular genetics ; LDL receptor ; hyperlipidaemia ; atherosclerosis ; HMG CoA reductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy and safety of the HMG CoA reductase inhibitor fluvastatin have been evaluated in a double blind study in 52 patients with familial hypercholesterolaemia. A standard AHA Phase II lipid lowering diet was prescribed throughout the study. After 6 weeks of a single blind dosage stabilisation period, in which patients received fluvastatin 40 mg qPM, patients were randomly allocated to one of two double blind treatment groups: group A (n=24) received fluvastatin 20 mg b. d. for 12 weeks and fluvastatin 20 mg AM + 40 mg PM for an additional 12 weeks; Group B (n=28) received fluvastatin 40 mg qPM during the entire study. Safety and tolerability were evaluated by the analysis of biochemical and haematological parameters, and ophthalmological and physical examinations. Efficacy was analysed by the determination of plasma lipids, lipoproteins and apoproteins. Fluvastatin 40 mg/d was associated with up to a 27.4% decrease in LDL-C and a 9.6% increase in HDL-C concentrations. Increasing the dose of fluvastatin from 20 mg b. d. to 60 mg per day in Group A was associated with a 7.1% decrease in LDL-C, a 12.1% increase of HDL-C and a 12.8% decrease in the LDL-C/HDL-C ratio. In comparison with Group B (40 mg qPM) LDL-C, HDL-C and the LDL-C/HDL-C ratio in Group A (60 mg) differed by −8.9%, 6.6% and −12%, respectively. During treatment with 40 mg qPM, one patient developed an asymptomatic but notable elevation of CK to 1823 U/l (normal range 0–100 U/l) that was caused by strenuous exercise. No other notable biochemical or haematological abnormalities were recorded. It is concluded that in patients with heterozygous FH the increase of fluvastatin from 40 to 60 mg/d provided an additional significant effect on plasma LDL-C and HDL-C levels and in the LDL-C/HDL-C ratio, without producing any deleterious effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315307
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...