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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Apolipoprotein(a) [apo(a)] exhibits a genetic size polymorphism explaining about 40% of the variability in lipoprotein(a) [Lp(a)] concentration in Tyroleans. Lp(a) concentrations and apo(a) phenotypes were determined in 7 ethnic groups (Tyrolean, Icelandic, Hungarian, Malay, Chinese, Indian, Black Sudanese) and the effects of the apo(a) size polymorphism on Lp(a) levels were estimated in each group. Average Lp(a) concentrations were highly significantly different among these populations, with the Chinese (7.0mg/dl) having the lowest and the Sudanese (46mg/dl) the highest levels. Apo(a) phenotype and derived apo(a) allele frequencies were also significantly different among the populations. Apo(a) isoform effects on Lp(a) levels were not significantly different among populations. Lp(a) levels were however roughly twice as high in the same phenotypes in the Indians, and several times as high in the Sudanese, compared with Caucasians. The size variation of apo(a) explains from 0.77 (Malays) to only 0.19 (Sudanese) of the total variability in Lp(a) levels. Together these data show (I) that there is considerable heterogeneity of the Lp(a) polymorphism among populations, (II) that differences in apo(a) allele frequencies alone do not explain the differences in Lp(a) levels among populations and (III) that in some populations, e.g. Sudanese Blacks, Lp(a) levels are mainly determined by factors that are different from the apo(a) size polymorphism.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 26 (1984), S. 549-553 
    ISSN: 1432-1041
    Keywords: pafenolol ; hypertension ; antihypertensive therapy ; beta1-blocking agent ; exercise tests ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Pafenolol, a new selective adrenergic beta1-blocking agent, has been tested for the first time in 6 hypertensive patients. After single oral doses of pafenolol 25 to 100 mg, there was a marked reduction in heart rate and systolic blood pressure during exercise tests. These effects were dose dependent. A significant positive correlation was found between the reduction in heart rate during exercise and the plasma level of pafenolol 5 hours after drug intake (correlation coefficient r=0.94). Side effects were mild and seemed to be dose dependent. It is concluded that this new beta1-blocking agent was effective in reducing blood pressure and was well tolerated.
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  • 3
    ISSN: 1432-1041
    Keywords: antihypertensive therapy ; sleep disturbances ; depression ; nightmares ; population study ; women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Of 1302 women aged 44–66 years in a population study in Göteborg, Sweden, in 1974–75, who were representative of women of all the ages studied in the area, 165 were taking antihypertensive drugs, mostly β-blockers and diuretics. The prevalence of sleep disturbances, nightmares, tiredness and melancholia or depression was studied in the total population sample, and a comparison was made between women who were or were not taking antihypertensive drugs. In the entire population sample no significant difference was found between the various age strata studied, although with increasing age there was a trend towards fewer complaints of nightmares, but a larger number of sleep disturbances as a whole. No difference was found between women taking or not taking various types of single-drug therapy or combinations of antihypertensive drugs.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of volcanology 51 (1989), S. 28-40 
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Peak intensities (magma discharge rate) of 45 Pleistocene and Holocene plinian eruptions have been inferred from lithic dispersal patterns by using a theoretical model of pyroclast fallout from eruption columns. Values range over three orders of magnitude from 1.6 × 106 to 1.1 × 109 kg/s. Magnitudes (total erupted mass) also vary over about three orders of magnitude from 2.0 × 1011 to 6.8 × 1014 kg and include several large ignimbrite-forming events with associated caldera formation. Intensity is found to be positively correlated with the magnitude when total erupted mass (tephra fall, surges and pyroclastic flows) is considered. Initial plinian fall phases with intensities in excess of 2.0 × 108 kg/s typically herald the onset of major pyroclastic flow generation and subsequent caldera collapse. During eruptions of large magnitude, the transition to pyroclastic flows is likely to be the result of high intensity, whereas the generation of pyroclastic flows in small magnitude eruptions may occur more often by reduction of magmatic volatile content or some transient change in magma properties. The correlation between plinian fall intensity and total magnitude suggests that the rate of magma discharge is related to the size of the chamber being tapped. A simple model is presented to account for the variation in intensity by progressive enlargement of conduits and vents and excess pressure at the chamber roof caused by buoyant forces acting on the chamber as it resides in the crust. Both processes are fundamentally linked to the absolute size of the pre-eruption reservoir. The data suggest that sustained eruption column heights (i.e. magma discharge rates) are indicators of eventual eruption magnitude, and perhaps eruptive style, and thus are key parameters to monitor in order to assess the temporal evolution of plinian eruptions.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of volcanology 51 (1989), S. 243-270 
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A study of pyroclastic deposits from the 1815 Tambora eruption reveals two distinct phases of activity, i.e., four initial tephra falls followed by generation of pyroclastic flows and the production of major co-ignimbrite ash fall. The first explosive event produced minor ash fall from phreatomagmatic explosions (F-1 layer). The second event was a Plinian eruption (F-2) correlated to the large explosion of 5 April 1815, which produced a column height of 33 km with an eruption rate of 1.1 × 108 kg/s. The third event occurred during the lull in major activity from 5 to 10 April and produced minor ash fall (F-3). The fourth event produced a 43-km-high Plinian eruption column with an eruption rate of 2.8 × 108 kg/s during the climax of activity on 10 April. Although very energetic, the Plinian events were of short duration (2.8 h each) and total erupted volume of the early (F-1 to F-4) fall deposits is only 1.8 km3 (DRE, dense rock equivalent). An abrupt change in style of activity occurred at end of the second Plinian event with onset of pyroclastic flow and surge generation. At least seven pyroclastic flows were generated, which spread over most of the volcano and Sanggar peninsula and entered the ocean. The volume of pyroclastic flow deposits on land is 2.6 km3 DRE. Coastal exposures show that pyroclastic flows entering the sea became highly fines depleted, resulting in mass loss of about 32%, in addition to 8% glass elutriation, as indicated by component fractionation. The subaqueous pyroclastic flows have thus lost about 40% of mass compared to the original erupted mixture. Pyroclastic flows and surges from this phase of the eruption are stratigraphically equivalent to a major ash fall deposit (F-5) present beyond the flow and surge zone at 40 km from the source and in distal areas. The F-5 fall deposit forms a larger proportion of the total tephra fall with increasing distance from source and represents about 80% of the total at a distance of 90 km and 92% of the total tephra fall from the 1815 eruption. The field relations indicate that the 20-km3 (DRE) F-5 deposit is a co-ignimbrite ash fall, generated largely during entrance of pyroclastic flows into the ocean. Based on the observed 40% fines depletion and component fractionation from the flows, the large volume of the F-5 co-ignimbrite ash requires eruption of 50 km3 (DRE, 1.4 × 1014 kg) pyroclastic flows.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of volcanology 57 (1996), S. 512-529 
    ISSN: 1432-0819
    Keywords: Facies ; Grain size ; Components ; Pyroclastic flows ; Subaerial ; Emplacement process
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The majority of tephra generated during the paroxysmal 1883 eruption of Krakatau volcano, Indonesia, was deposited in the sea within a 15-km radius of the caldera. Two syneruptive pyroclastic facies have been recovered in SCUBA cores which sampled the 1883 subaqueous pyroclastic deposit. The most commonly recovered facies is a massive textured, poorly sorted mixture of pumice and lithic lapilli-to-block-sized fragments set in a silty to sandy ash matrix. This facies is indistinguishable from the 1883 subaerial pyroclastic flow deposits preserved on the Krakatau islands on the basis of grain size and component abundances. A less common facies consists of well-sorted, planarlaminated to low-angle cross-bedded, vitric-enriched silty ash. Entrance of subaerial pyroclastic flows into the sea resulted in subaqueous deposition of the massive facies primarily by deceleration and sinking of highly concentrated, deflated components of pyroclastic flows as they traveled over water. The basal component of the deposit suggests no mixing with seawater as inferred from retention of the fine ash fraction, high temperature of emplacement, and lack of traction structures, and no significant hydraulic sorting of components. The laminated facies was most likely deposited from low-concentration pyroclastic density currents generated by shear along the boundary between the submarine pyroclastic flows and seawater. The Krakatau deposits are the first well-documented example of true submarine pyroclastic flow deposition from a modern eruption, and thus constitute an important analog for the interpretation of ancient sequences where subaqueous deposition has been inferred based on the facies characteristics of encapsulating sedimentary sequences.
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  • 7
    ISSN: 1432-0819
    Keywords: Key words Krakatau ; Pyroclastic flows ; Pyroclastic surge ; Tsunamis ; Volcanic hazard ; Explosive eruption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Pyroclastic deposits from the 1883 eruption of Krakatau are described from areas northeast of the volcano on the islands of Sebesi, Sebuku, and Lagoendi, and the southeast coast of Sumatra. Massive and poorly stratified units formed predominantly from pyroclastic flows and surges that traveled over the sea for distances up to 80 km. Granulometric and lithologic characteristics of the deposits indicate that they represent the complement of proximal subaerial and submarine pyroclastic flow deposits laid down on and close to the Krakatau islands. The distal deposits exhibit a decrease in sorting coefficient, median grain size, and thickness with increasing distance from Krakatau. Crystal fractionation is consistent with the distal facies being derived from the upper part of gravitationally segregated pyroclastic flows in which the relative amount of crystal enrichment and abundance of dense lithic clasts diminished upwards. The deposits are correlated to a major pyroclastic flow phase that occurred on the morning of 27 August at approximately 10 a.m. Energetic flows spread out away from the volcano at speeds in excess of 100 km/h and traveled up to 80 km from source. The flows retained temperatures high enough to burn victims on the SW coast of Sumatra. Historical accounts from ships in the Sunda Straits constrain the area affected by the flows to a minimum of 4×103 km2. At the distal edge of this area the flows were relatively dilute and turbulent, yet carried enough material to deposit several tens of centimeters of tephra. The great mobility of the Krakatau flows from the 10 a.m. activity may be the result of enhanced runout over the sea. It is proposed that the generation of steam at the flow/seawater interface may have led to a reduction in the sedimentation of particles and consequently a delay in the time before the flows ceased lateral motion and became buoyantly convective. The buoyant distal edge of these ash- and steam-laden clouds lifted off into the atmosphere, leading to cooling, condensation, and mud rain.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of volcanology 57 (1996), S. 512-529 
    ISSN: 1432-0819
    Keywords: Key words Facies ; Grain size ; Components ; Pyroclastic flows ; Subaerial ; Emplacement process
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  The majority of tephra generated during the paroxysmal 1883 eruption of Krakatau volcano, Indonesia, was deposited in the sea within a 15-km radius of the caldera. Two syneruptive pyroclastic facies have been recovered in SCUBA cores which sampled the 1883 subaqueous pyroclastic deposit. The most commonly recovered facies is a massive textured, poorly sorted mixture of pumice and lithic lapilli-to-block-sized fragments set in a silty to sandy ash matrix. This facies is indistinguishable from the 1883 subaerial pyroclastic flow deposits preserved on the Krakatau islands on the basis of grain size and component abundances. A less common facies consists of well-sorted, planar-laminated to low-angle cross-bedded, vitric-enriched silty ash. Entrance of subaerial pyroclastic flows into the sea resulted in subaqueous deposition of the massive facies primarily by deceleration and sinking of highly concentrated, deflated components of pyroclastic flows as they traveled over water. The basal component of the deposit suggests no mixing with seawater as inferred from retention of the fine ash fraction, high temperature of emplacement, and lack of traction structures, and no significant hydraulic sorting of components. The laminated facies was most likely deposited from low-concentration pyroclastic density currents generated by shear along the boundary between the submarine pyroclastic flows and seawater. The Krakatau deposits are the first well-documented example of true submarine pyroclastic flow deposition from a modern eruption, and thus constitute an important analog for the interpretation of ancient sequences where subaqueous deposition has been inferred based on the facies characteristics of encapsulating sedimentary sequences.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of volcanology 57 (1996), S. 493-511 
    ISSN: 1432-0819
    Keywords: Krakatau ; Pyroclastic flows ; Pyroclastic surge ; Tsunamis ; Volcanic hazard ; Explosive eruption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Pyroclastic deposits from the 1883 eruption of Krakatau are described from areas northeast of the volcano on the islands of Sebesi, Sebuku, and Lagoendi, and the southeast coast of Sumatra. Massive and poorly stratified units formed predominantly from pyroclastic flows and surges that traveled over the sea for distances up to 80 km. Granulometric and lithologic characteristics of the deposits indicate that they represent the complement of proximal subaerial and submarine pyroclastic flow deposits laid down on and close to the Krakatau islands. The distal deposits exhibit a decrease in sorting coefficient, median grain size, and thickness with increasing distance from Krakatau. Crystal fractionation is consistent with the distal facies being derived from the upper part of gravitationally segregated pyroclastic flows in which the relative amount of crystal enrichment and abundance of dense lithic clasts diminished upwards. The deposits are correlated to a major pyroclastic flow phase that occurred on the morning of 27 August at approximately 10 a.m. Energetic flows spread out away from the volcano at speeds in excess of 100 km/h and traveled up to 80 km from source. The flows retained temperatures high enough to burn victims on the SW coast of Sumatra. Historical accounts from ships in the Sunda Straits constrain the area affected by the flows to a minimum of 4x103 km2. At the distal edge of this area the flows were relatively dilute and turbulent, yet carried enough material to deposit several tens of centimeters of tephra. The great mobility of the Krakatau flows from the 10 a.m. activity may be the result of enhanced runout over the sea. It is proposed that the generation of steam at the flow/seawater interface may have led to a reduction in the sedimentation of particles and consequently a delay in the time before the flows ceased lateral motion and became buoyantly convective. The buoyant distal edge of these ash-and steam-laden clouds lifted off into the atmosphere, leading to cooling, condensation, and mud rain.
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  • 10
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Das spreading centre des Nord-Fidschi-Beckens setzt sich an seinem südlichsten Ende in die Inselbogen-Kruste des noch wenig bekannten Hunter-Rückens fort. Wir definieren 9 magmatische Gruppen auf der Basis der Hauptelement-Zusammensetzung von Gläsern und der Zusammensetzung von Olivin und Spinell in Proben die das Forschungsschiff R/V Akademiker A. Nesmeyanov von 26 Stellen im Jahr 1990 aufgesammelt hat. Zu diesen gehören Gruppen von Boniniten, Inselbogentholeiiten (IAT), Basalten zentralozeanischer Rücken (MORB), angereicherte zentralozeanische Rücken (E-MORB), Olivin-porphyritische Andesite und basaltische Andesite, sowie Na-Rhyolite. Primitive Laven mit Olivinkristallen, die reich an Forsterit-Komponenten sind, kommen in allen diesen Gruppen, mit Ausnahme der Rhyolite, vor. Wir legen über 100 Glas-Analysen von Gesteinen aus diesem Gebiet vor und über 300 Olivin-Spinell-Paare für Vertreter aller der hier identifizierten magmatischen Gruppen, mit Ausnahme der Natriumrhyolite. Die MORB in diesem Gebiet sind wahrscheinlich an dem aktiven Spreading Center im Südteil des Nord-Fidschi-Beckens entstanden. Das nebeneinander Vorkommen von seichten heißen MORB-Quellen Diapiren, die MORB in diesem Gebiet erzeugen, und der Sub-Inselbogen, wasserhaltige, refraktäre obere Mantel unter dem Hunter Rücken führen zu geeigneten petrogenetischen Bedingungen für die Entstehung einer Vielfalt von Magmatypen, von Inselbogentholeiiten bis zu sehr Kalziumreichen Boniniten. Die letzteren wurden in 11 Dredge-Proben gefunden. Die E-MORS Laven, die aus dem extremen Südteil des Nord-Fidschi-Beckens entnommen wurden, sind im wesentlichen mit jenen identisch, die aus der benachbarten älteren Kruste des Süd-Fidschi-Beckens stammen. Es wird vermutet, daß die letzteren entweder aus dem Süd-Fidschi-Becken während einer Episode obliger Subduktion, die in den letzten 5 Millionen Jahren zur Entstehung des Hunter Ridge geführt hat, abgeschert wurden, oder auch daß Teile der Kruste des Süd-Fidschi-Beckens in das Nord-Fidschi-Becken inkorporiert wurden als Subduktionszonen gegenüber dem Vanuato-Bogen sich nach Süden fortbewegten.
    Notes: Summary At its southernmost end, the main spreading centre of the North Fiji Basin is propagating into arc crust of the poorly-known Hunter Ridge. We define nine magmatic groups from major element glass chemistry and olivine and spinel compositions in samples dredged from twenty six sites in this area by the “R/V Academician A. Nesmeyanov” in 1990. These include groups of boninites, island arc tholeiites (IAT), mid-ocean ridge basalts (MORB), enriched mid-ocean ridge basalts (E-MORB), olivine porphyritic andesites and basaltic andesite and Na-rhyolites. Primitive lavas containing highly forsteritic olivine phenocrysts are common in all the groups, except for the rhyolites. We report over 100 glass analyses for dredged rocks from this region, and about 300 olivine-spinel pairs for representatives of all the magmatic groups identified, except the Na-rhyolites. The MORB in this region are probably produced at the propagating spreading centre in the southern part of the North Fiji Basin. Juxtaposition of shallow, hot MORB-source diapirs supplying the MORB in this area, and the sub-arc damp, refractory upper mantle beneath the Hunter Ridge, provides suitable petrogenetic conditions to produce a range of magma types, from island arc tholeiites through to high-Ca boninites. The latter were recovered in eleven dredges. The E-MORB lavas recovered from the extreme southern margin of the North Fiji Basin are shown to be essentially identical to those dredged from adjacent older South Fiji Basin crust. It is hypothesized that the former were either scraped off the South Fiji Basin crust during an episode of oblique subduction that may have generated the Hunter Ridge during the last 5 Myr, or alternatively, that slices of the South Fiji Basin crust were trapped and incorporated into the North Fiji Basin as the subduction zones fronting the Vanuatu arc stepped or propagated southward.
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