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  • 1
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    Synchronized broadcast spawning by six invertebrates (Echinodermata and Mollusca) in the north-western Red Sea (2021)
    Springer
    Details
    Publication Date: 2021-04-05
    Description: On the evenings of June 11 and 12, 2019, 5 and 6 days before full moon, broadcast spawning by four echinoderm species and two mollusc species was observed on the Marsa Shagra reef, Egypt (25° 14′ 44.2" N, 34° 47′ 49.0" E). Water temperature was 28 °C and the invertebrates were observed at 2–8 m depth. The sightings included a single basket star Astroboa nuda (Lyman 1874), 2 large Tectus dentatus (Forskal 1775) sea snails, 14 individuals of the Leiaster cf. leachi (Gray 1840) sea star and 1 Mithrodia clavigera (Lamarck 1816) sea star, 3 Pearsonothuria graeffei (Semper 1868) sea cucumbers, and 2 giant clams, Tridacna maxima (Röding 1798). The observations presented here provide relevant information on broadcast spawning of non-coral invertebrate taxa in the Red Sea, where spawning is considerably less well documented than in other tropical geographical regions such as the Indo-Pacific and Caribbean.
    Print ISSN: 0025-3162
    Electronic ISSN: 1432-1793
    Topics: Biology
    Published by Springer
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Identification of D/D translocations in mentally retarded patients (1973)
    Springer
    Human genetics 〈Berlin〉 17 (1973), S. 165-168 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Eine Routine-Chromosomenanalyse von zwei Patienten mit geistiger Retardation zeigte zwei 45,D-,D-,t(DqDq)+-Karyotypen. Mit Hilfe einer Giemsamusterfärbung war es möglich, die respektiven Translokationschromosomen als t(13q14q) und t(14q15q) zu identifizieren.
    Notes: Summary Routine chromosome analysis of two patients with severe mental retardation revealed two 45,D-,D-,t(DqDq)+karyotypes. With the aid of a Giemsa banding technique the translocation chromosomes were identified as a t(13q14q) and a t(14q15q).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277911
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  • 3
    Electronic Resource
    Electronic Resource
    Colonic epithelium reactive monoclonal antibodies (1989)
    Springer
    Histochemistry and cell biology 92 (1989), S. 397-406 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have produced a small library of colonic mucosa and colorectal carcinoma reactive monoclonal antibodies (MoAbs) by immunizations with extracts of human colon cancer tissue and a human colon cancer cell line. Hybridoma supernatants were tested on (normal and neoplastic) human tissues by immunoperoxidase methods to evaluate organ or tissue specificity. Initial biochemical characterization of the target antigens was performed by gelpermeation chromatography, Western blotting and competition assays. Based upon the immunoreactivity patterns and the characteristics of the antigen four groups of MoAbs could be distinguished. The first group concerns the antibodies PAR-LAM 3, 9 and 10. These antibodies react with an 87 kDa protein moiety in high molecular weight (2–5×106 Da) glycoproteins. In intestinal and colon mucosa these antibodies showed diffuse binding with goblet cells. In colon carcinoma decreased reactivity with these MoAbs was found. The second group consists of antibodies PARLAM 8, 12 and 13. These antibodies react with large (〉5×106 Da) glycoproteins, most likely with carbohydrate epitopes. By immunohistochemistry in normal colon mucosa the antibodies all show granular supranuclear reactivity with goblet cells. These antibodies show increased reactivity with colon adenomas and adenocarcinomas. A third group is formed by PARLAM 2, which also reacts with a large (〉5×106 Da) glycoprotein, showing a granular distribution in goblet cells. In colon carcinomas more extensive expression is found than in normal colonic mucosa. Finally, the fourth group consists of PARLAM 11, which also reacts with a large (〉5×106 Da) glycoprotein, located in the brush border of colonic columnar cells. These antibodies might be useful tools for the analysis of the expression of mucin related glycoproteins in normal, preneoplastic and neoplastic colon mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492497
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  • 4
    Electronic Resource
    Electronic Resource
    Versuch einer systemtheoretischen Erklärung des Alpha-Rhythmus (1971)
    Springer
    Naturwissenschaften 58 (1971), S. 91-93 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00595018
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  • 5
    Electronic Resource
    Electronic Resource
    A double missense mutation in the ATM gene of a Dutch family with ataxia telangiectasia (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 187-191 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ataxia telangiectasia (AT) is an autosomal recessive disorder characterized by cerebellar ataxia, telangiectasia, immunodeficiency, elevated α-fetoprotein levels, chromosomal instability, predisposition to cancer, and radiation sensitivity. We report the identification of a new, double missense mutation in the ataxia telangiectasia gene (ATM) of a Dutch family. This homozygous mutation consists of two consecutive base substitutions in exon 55: a T→G transversion at position 7875 of the ATM cDNA and a G→C transversion at position 7876. These transversions were confirmed by polymerase chain reaction/primer-induced restriction analysis with CelII. The double base substitution results in an amino acid change of an aspartic acid to a glutamic acid at codon 2625 and of an alanine to a proline at codon 2626 of the ATM protein. Both amino acids are conserved between the ATM protein and its functional homolog, the Atm gene product in the mouse. Furthermore, the Chou-Fasman and Robson predictions both demonstrate a change in the secondary structure of the ATM protein carrying the D2625E/A2626P mutation. These findings suggest that the double base substitution in the ATM gene is a disease-causing mutation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050675
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  • 6
    Electronic Resource
    Electronic Resource
    Tunicamycin-inhibited carrot somatic embryogenesis can be restored by secreted cationic peroxidase isoenzymes (1991)
    Springer
    Planta 184 (1991), S. 478-486 
    Details
    ISSN: 1432-2048
    Keywords: Daucus (somatic embryogenesis) ; Embryogenesis (somatic) ; Peroxidase, cationic (isoenzymes) ; Protein glycosylation ; Glycoprotein secretion ; Somatic embryogenesis ; Tunicamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Somatic embryogenesis of carrot (Daucus carota L.) is inhibited by the glycosylation inhibitor tunicamycin. This inhibition is reversible by the addition of correctly glycosylated glycoproteins which have been secreted into the culture medium. To identify the proteins responsible for complementation, glycoproteins present in the medium of embryo cultures were purified and tested for their activity in the tunicamycin inhibition/ complementation assay. A 38-kDa glycoprotein was purified that could restore embryogenesis to more than 50% of that in untreated controls. This 38-kDa glycoprotein was identified as a heme-containing peroxidase on the basis of its A405/A280 ratio (Reinheit Zahl or RZ) and enzyme activity. The 38-kDa peroxidase consisted of four different cationic isoenzymes of which only one or possibly two appeared active in the complementation assay. The cationic peroxidase isoenzymes from the carrot medium could be effectively replaced by cationic horseradish peroxidases which depended on their catalytic properties for their ability to restore tunicamycin-inhibited somatic embryogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197895
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  • 7
    Electronic Resource
    Electronic Resource
    Challenges of the LHC: the detector challenge (2004)
    Springer
    The European physical journal 34 (2004), S. 61-65 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2004-01768-6
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  • 8
    Electronic Resource
    Electronic Resource
    Over arbeiderswoningen, naar aanleiding van het nuts-verslag over dat onderwerp (1891)
    Springer
    De economist 40 (1891), S. 802-837 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02213275
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  • 9
    Electronic Resource
    Electronic Resource
    Uit de economist van 1873 (1973)
    Springer
    De economist 121 (1973), S. 332-332 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02367132
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  • 10
    Electronic Resource
    Electronic Resource
    Supporting Timing Analysis by Automatic Bounding of Loop Iterations (2000)
    Springer
    Real-time systems 18 (2000), S. 129-156 
    Details
    ISSN: 1573-1383
    Keywords: hard real-time systems ; worst-case execution time ; static analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Static timing analyzers, which are used to analyze real-time systems, need to know the minimum and maximum number of iterations associated with each loop in a real-time program so accurate timing predictions can be obtained. This paper describes three complementary methods to support timing analysis by bounding the number of loop iterations. First, an algorithm is presented that determines the minimum and maximum number of iterations of loops with multiple exits. Even when the number of iterations cannot be exactly determined, it is desirable to know the lower and upper iteration bounds. Second, when the number of iterations is dependent on unknown values of variables, the user is asked to provide bounds for these variables. These bounds are used to determine the minimum and maximum number of iterations. Specifying the values of variables is less error prone than specifying the number of loop iterations directly. Finally, a method is given to tightly predict the execution time of inner loops whose number of iterations is dependent on counter variables of outer level loops. This is accomplished by formulating the total number of iterations of a loop in terms of summations and solving the resulting equation. These three methods have been successfully integrated in an existing timing analyzer that predicts the performance for optimized code on a machine that exploits caching and pipelining. The result is tighter timing analysis predictions and less work for the user.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008189014032
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