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  • Springer  (4)
  • Wiley-Blackwell  (1)
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  • 1
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    Drug monitoring of quinine by HPLC in cerebral malaria with acute renal failure treated by haemofiltration (1987)
    Springer
    Details
    Publication Date: 1987-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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    PAPER CURRENT
  • 2
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    High susceptibility for diploidy in ovulated oocytes from XO mice (1986)
    Springer
    Details
    Publication Date: 1986-04-01
    Print ISSN: 0340-6717
    Electronic ISSN: 1432-1203
    Topics: Biology , Medicine
    Published by Springer
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  • 3
    Electronic Resource
    Electronic Resource
    Drug monitoring of quinine by HPLC in cerebral malaria with acute renal failure treated by haemofiltration (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 293-296 
    Details
    ISSN: 1432-1041
    Keywords: falciparum malaria ; quinine ; acute renal failure ; HPLC ; haemofiltration ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The monitoring of quinine by HPLC in 3 patients suffering from cerebral malaria with acute renal failure and treated by haemofiltration is reported. The recommended dose of quinine in this situation is reduced to 10 to 15 mg·kg−1·day−1. However, in the first patient, when given quinine 10 mg kg−1·day−1 the plasma concentration was mainly below the recommended therapeutic range of 5 to 15 mg/l. In consequence, the dose of quinine in the second patient was elevated to quinine dihydrochloride 15.1 mg·kg−1·day−1 which produced plasma concentrations in the low therapeutic range. In the third patient, an unreduced dose of quinine dihydrochloride 25.7 mg·kg−1·day−1 was employed, resulting in plasma concentrations above 15 mg/l, which is generally assumed to be toxic, although, no sign of acute quinine toxicity was seen. The antimalarial effect in all three patients was satisfactory. Quinine was estimated in the haemofiltrate in two patients and was found to be below the limit of sensitivity (0.25 mg/l). Plasma quinine did not change during or shortly after haemofiltration. It is concluded that in case of acute renal failure in cerebral malaria the dose of quinine should be reduced, but that the common recommendation of 10 to 15 mg·kg−1·day−1 may be too low, and that haemofiltration has no marked influence on the total body clearance of quinine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637565
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  • 4
    Electronic Resource
    Electronic Resource
    High susceptibility for diploidy in ovulated oocytes from XO mice (1986)
    Springer
    Human genetics 〈Berlin〉 72 (1986), S. 323-326 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Adult female mice of the “sensitive” NMRI/Han strain ovulate diploid oocytes after gonadotropin treatment. Other mouse strains are “non-sensitive” with respect to the ovulation of such diploid oocytes. In this study we combined the impaired ovarian situation in the XO karyotype with the trait “diploidy”, which is determined genetically, by mating Ta/O (Ta=Tabby) females of C3Hx101 background to males of the NMRI/Han strain. The adult female F1 hybrids were stimulated to ovulation by gonadotropins and identified by their karyotype (XX or XO). The cytogenetic analysis of ovulated oocytes revealed a low level of diploidy in the XX littermates (1.0%), but a very high level in females with the XO karyotype (24.6%). All of the XO females ovulated at least one diploid oocyte. We suggest that it is the XO status which drastically impairs meiosis I in our “gonadotropin-sensitive” F1 females due to (1) alterations of the developmental program within the oocyte, (2) a disturbed communication between oocyte and follicle, (3) a preferential maturation and ovulation of “follicles at risk”, or (4) an exceptional recruitment of many such follicles, by, e.g., a premature responsiveness to gonadotropins in our XO females. An interdependence of several such mechanisms is possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290958
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  • 5
    Electronic Resource
    Electronic Resource
    α-Substituierte Phosphonate. XXXI. Zur Reaktion von N,N,N′,N′-Tetramethylchlorformamidiniumchlorid mit P-III-Verbindungen (1978)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 320 (1978), S. 389-394 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α-Substituted Phosphonates. XXXI. The Reaction of N,N,N′,N′-Tetramethyl Chloroformamidinium Chloride with P(III) CompoundsN,N,N′,N′-Tetramethyl chloroformamidiniumchloride (4) does not react with triethyl phosphite (TEP) or isopropyl diphenylphosphinate to give the expected bisphosphoryl derivatives 7 and 11, respectively, but primarily the monophosphorylated amidinium salts 6 and 10 respectively. The phosphine oxide 10 is stable, while 6 undergoes an elimination of ethyl chloride to the betain 8. Even under more drastic conditions the reaction of 4 or 8 with TEP does not lead to the expected bis(dimethylamino)bisphosphonate 7, but to the monoaminated bisphosphonate 1, involving a reduction step. Similar reduction has been observed under mild conditions in Michaelis-Arbusov reaction of dichloromethylenimonium chloride, yielding the expected trisphosphonate 2 and the bisphosphonate 1 as a by-product.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19783200305
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