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  • 1
    Publication Date: 2012-08-23
    Description: Detailed analyses of the chromatin around the BIM promoter has revealed that latent Epstein–Barr virus (EBV) triggers the recruitment of polycomb repressive complex 2 (PRC2) core subunits and the trimethylation of histone H3 lysine 27 (H3K27me3) at this locus. The recruitment is absolutely dependent on nuclear proteins EBNA3A and EBNA3C; what is more, epitope-tagged EBNA3C could be shown bound near the transcription start site (TSS). EBV induces no consistent changes in the steady-state expression of PRC2 components, but lentivirus delivery of shRNAs against PRC2 and PRC1 subunits disrupted EBV repression of BIM . The activation mark H3K4me3 is largely unaltered at this locus irrespective of H3K27me3 status, suggesting the establishment of a ‘bivalent’ chromatin domain. Consistent with the ‘poised’ nature of these domains, RNA polymerase II (Pol II) occupancy was not altered by EBV at the BIM TSS, but analysis of phospho-serine 5 on Pol II indicated that EBNA3A and EBNA3C together inhibit initiation of BIM transcripts. B cell lines carrying EBV encoding a conditional EBNA3C-oestrogen receptor-fusion revealed that this epigenetic repression of BIM was reversible, but took more than 3 weeks from when EBNA3C was inactivated.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 2
    Publication Date: 2014-06-20
    Description: We investigate the effects of galaxy formation on the baryonic acoustic oscillation (BAO) peak by applying semi-analytic modelling techniques to the Millennium-XXL, a 3 10 11 particle N -body simulation of similar volume to the future Euclid survey. Our approach explicitly incorporates the effects of tidal fields and stochasticity on halo formation, as well as the presence of velocity bias, spatially correlated merger histories, and the connection of all these with the observable and physical properties of galaxies. We measure significant deviations in the shape of the BAO peak from the expectations of a linear bias model built on top of the non-linear dark matter distribution. We find that the galaxy correlation function shows an excess close to the maximum of the BAO peak ( r ~ 110 h –1 Mpc) and a deficit at r ~ 90 h –1 Mpc. Depending on the redshift, selection criteria and number density of the galaxy samples, these biased distortions can be up to 5 per cent in amplitude. They are, however, largely absorbed by marginalization over nuisance parameters in current analytical modelling of the BAO peak in configuration space, in particular into the parameter that controls the broadening due to non-linear evolution. As a result, the galaxy formation effects detected here are unlikely to bias the high-precision measurements planned by the upcoming generation of wide-field galaxy surveys.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 3
    Publication Date: 2016-03-14
    Description: We introduce methods which allow observed galaxy clustering to be used together with observed luminosity or stellar mass functions to constrain the physics of galaxy formation. We show how the projected two-point correlation function of galaxies in a large semi-analytic simulation can be estimated to better than ~10 per cent using only a very small subsample of the subhalo merger trees. This allows measured correlations to be used as constraints in a Monte Carlo Markov Chain exploration of the astrophysical and cosmological parameter space. An important part of our scheme is an analytic profile which captures the simulated satellite distribution extremely well out to several halo virial radii. This is essential to reproduce the correlation properties of the full simulation at intermediate separations. As a first application, we use low-redshift clustering and abundance measurements to constrain a recent version of the Munich semi-analytic model. The preferred values of most parameters are consistent with those found previously, with significantly improved constraints and somewhat shifted ‘best’ values for parameters that primarily affect spatial distributions. Our methods allow multi-epoch data on galaxy clustering and abundance to be used as joint constraints on galaxy formation. This may lead to significant constraints on cosmological parameters even after marginalizing over galaxy formation physics.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 4
    Publication Date: 2014-08-01
    Description: We develop and test a new statistical method to measure the kinematic Sunyaev-Zel'dovich (kSZ) effect. A sample of independently detected clusters is combined with the cosmic flow field predicted from a galaxy redshift survey in order to derive a matched filter that optimally weights the kSZ signal for the sample as a whole given the noise involved in the problem. We apply this formalism to realistic mock microwave skies based on cosmological N -body simulations, and demonstrate its robustness and performance. In particular, we carefully assess the various sources of uncertainty, cosmic microwave background primary fluctuations, instrumental noise, uncertainties in the determination of the velocity field, and effects introduced by miscentring of clusters and by uncertainties of the mass-observable relation (normalization and scatter). We show that available data ( Planck maps and the MaxBCG catalogue) should deliver a 7.7 detection of the kSZ. A similar cluster catalogue with broader sky coverage should increase the detection significance to ~13. We point out that such measurements could be binned in order to study the properties of the cosmic gas and velocity fields, or combined into a single measurement to constrain cosmological parameters or deviations of the law of gravity from General Relativity.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Irrigation science 6 (1985), S. 3-10 
    ISSN: 1432-1319
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The mean velocity at which water flowed through large undisturbed cores of soil was determined from the breakthrough of surface-applied Cl−, using a transfer function based on the normal distribution of the logarithm of cumulative drainage. For soils ranging in texture from sandy loam to silty clay loam, mean pore water velocities varied from 7 to 30 cm h−1 for an input rate of 2 cm h−1. Antibiotic-resistant Escherichia coli applied to the soil surface appeared to be transported through large pores only (〉 10–15 μm diameter), and the relative concentration in the effluent (C/C0) did not change significantly with effluent volume. Mean C/C0 values for E. coli in these soils, which ranged from 0.003 to 0.94, could be predicted from the mean pore water velocity derived from Cl− transport.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 28 (1998), S. 889-894 
    ISSN: 1572-8838
    Keywords: zinc ; zinc-nickel ; hydrogen ; permeation ; inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The inhibition of hydrogen permeation by zinc-nickel electrodeposited alloy was investigated using the Devanathan–Stachurski permeation technique. The hydrogen evolution and hydrogen permeation rates for the zinc–nickel alloy electrodeposits on iron are compared with the rates for bare iron, zinc electroplated on iron, and nickel electroplated on iron. Hydrogen evolution rates and hydrogen permeation rates were followed as functions of time at different applied potentials. The hydrogen permeation inhibition for thin zinc–nickel electroplates (20s at 10mAcm−2 and 10s at 20mAcm−2) averaged 80% and intermediate to that of nickel and zinc. This inhibition was considered to be mostly due to kinetic effects. Zinc–nickel electroplated for 20 and 40min. at 10mAcm−2 inhibited the hydrogen permeation greater than 95% as compared to bare iron. This inhibition was due to both kinetics and the barrier effect caused by the diffusion resistance of the membrane.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The nature of the open circuit potentials of Ti and TiC electrodes in titanium(II) and titanium(III) chloride solutions, the apparent valency of the titanium ions in the melt immediately after the anodic dissolution of TiC and Ti, as well as the anodic dissolution of Ti, have been investigated in order to explain the oxidation-reduction process of titanium in lithium chloride-potassium chloride eutectic melts. It is shown that the standard electrode potential for TiC/Ti(III) exceeds that for the oxidation of Ti(II) to Ti(III). The anodic dissolution of TiC anodes give stable Ti(III) species at the standard electrode potentials the contrary to the behaviour of Ti metal anodes where the stable species are Ti(II) ions. Titanium electrodes in TiCl3 solutions of molten lithium chloride-potassium chloride melts behave according to the Ti(III)/Ti(II) redox electrode potential of the reaction: Ti+TiCl3⇌3TiCl2. An anodic dissolution mechanism compatible with all the experimental facts is proposed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 25 (1995), S. 212-218 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract It is shown that the underpotential deposition of zinc on AISI 4340 steel and Inconel 718 alloys inhibits the hydrogen evolution reaction and the degree of hydrogen ingress. In the presence of monolayer coverage of zinc on the substrate surfaces, the hydrogen evolution current densities are reduced 46% and 68% compared with the values obtained on bare AISI 4340 steel and Inconel 718 alloy, respectively. As a consequence, the underpotential deposition of zinc on AISI 4340 steel and Inconel 718 alloy membrane reduces the steady state hydrogen permeation current density by 51% and 40%, respectively.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 25 (1995), S. 315-325 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The initial current density distribution in lead acid batteries with tubular lead dioxide electrodes and flat lead electrodes has been studied by means of a two-dimensional model and experimental verification by polarization curves and potential transients during galvanostatic discharge. The cell geometry was modelled with and without separators and a tubular electrode envelope. The governing equations were solved with a finite element method. It was found that the tube envelope has a large impact on the current density distribution and had to be incorporated into the model to fit the experimental results. Although the envelope increases the ohmic losses, it has the positive effect of giving a more uniform current distribution around the electrode tube. A lead acid cell with tubular positive electrodes and flat negative electrodes can therefore be approximated by a one-dimensional model consisting of a positive electrode tube placed concentrically in a cylindrical lead electrode. The two-dimensional model was further used to study the effects of different design factors, for example, cell width and kinetic parameters of the lead dioxide electrode.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 29 (1999), S. 361-369 
    ISSN: 1572-8838
    Keywords: metal-hydrides ; alloy weight ; binder content ; electrochemical impedance spectroscopy ; model simulations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract LaNi4.27Sn0.24 electrodes were characterized using electrochemical techniques at different alloy weights and binder contents. For a given alloy weight, the polarization resistance (Rp) increases with the state of charge (SOC). This arises due to changes from α to β phase at the alloy surface. The electroactive surface area for the hydrogen adsorption/desorption reaction changes with SOC and this also contributes to the variation of Rp. Since the interfacial area increases with alloy content, the polarization resistance decreases with increase in the alloy weight. An increase in the alloy weight reduces Rp and lowers the total resistance. The electrode utilization decreases by increasing the binder content and the electrode weight. A theoretical model is presented to study the effect of alloy weight and particle size on the electrode performance. The model simulations predict lowering of the utilization with increase in the electrode weight. The effect of particle size on the energy and power density of the electrode was also studied.
    Type of Medium: Electronic Resource
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