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  • Springer  (243)
  • Blackwell Science Ltd
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    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 194 (1984), S. 107-120 
    ISSN: 1432-041X
    Keywords: Cellular asymmetry reversal ; Cell surface patterns ; Mutations affecting patterns ; Ciliate development ; Tetrahymena thermophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The development of the oral apparatus (OA) and of neighboring ciliary structures ofTetrahymena thermophila was analyzed in cells homozygous for ajanus (jan A) mutation plus a recessiveenhancer of janA (eja). Such cells frequently possess two OAs located on opposite sides of the cell, a primary (1°) OA previously reported to be normal, and a secondary (2°) OA previously reported to express a mirror-reversal of right-left asymmetry. This study confirms the reality of a reversal in the gross orientation of membranelles in most developing 2° OAs. It also shows that there is a reversal of asymmetry in the pattern of resorption of basal bodies of ciliary rows adjacent to the 2° OA, and in the arrangement of basal-body couplets making up the portion of the apical “crown” of the cell situated close to the 2° OA. However, the locations at which membranelles of the 2° OA become modified during late phases of oral development remain normal, so that membranelles of 2° OAs are superimposable on those of 1° OAs. In addition, the membranelles of 2° OAs frequently undergo a rotation during the final phases of oral development, so that even their spatial orientation becomes normal. This mixture of reversed and normal features can be accounted for by postulating a superimposition of a reversed largescale asymmetry on a normal local asymmetry of ciliary units. This postulate predicts that no single mutation can bring about a complete mirror-image reversal of ciliary patterns. 1° OAs appear normal by light microscopy. However, detailed analysis of SEM, preparations of isolated 1° OAs indicate subtle abnormalities of basal body arrangement in some of these OAs.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
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    Springer
    Development genes and evolution 196 (1987), S. 421-433 
    ISSN: 1432-041X
    Keywords: Cell surface patterns ; Mutations affecting patterns ; Ciliate development ; Tetrahymena thermophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A single-gene recessive mutation, bcd (broadened cortical domains), of Tetrahymena thermophila is characterized by a variable broadening of the spatial domains within which cortical organelles, including both the contractile vacuole pores (CVP) and oral apparatus (OA), are formed. The phenotype is not temperature-sensitive. During the development of the organelles of the mutant prior to cell division, extra CVPs and extra oral primordia (OP) appear near ciliary rows adjacent to the rows at which these structures normally form. In the later stages of development, some, but not all, of these extra structures are resorbed, or in the case of the oral domain, multiple adjacent OPs may be completely or partially integrated into a single enlarged OA. When multiple OAs persist, one or more of these may display a reversed orientation reminiscent of those encountered in janus mutants. However, unlike janus, bcd cells do not express any sign of a mirror-image global organization. Our results can best be accounted for by postulating that the bcd mutation affects some common determinant of the widths of both CVP and OA domains. Studies are in progress which explore the relationship between this width-determining mechanism(s) and the mechanism(s) determining the location of cortical organelles around the cell circumference.
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    Electronic Resource
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    Development genes and evolution 197 (1988), S. 476-489 
    ISSN: 1432-041X
    Keywords: Cell surface patterns ; Double mutant analysis ; Ciliate development ; Tetrahymena thermophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An analysis of bcd, janA; bcd, janB; and bcd, janC double-mutant phenotypes in Tetrahymena thermophila has allowed us to examine patterning processes affected by two different classes of mutations. bcd brings about a broadening of the oral and contractile vacuole pore domains in the ciliate cortex, while the janus mutations generate a mirror-image duplication of the ventral cortical pattern. We observed both bcd and janus characteristics expressed in the double mutants, as well as features unique to the double-mutant. Temperature-shift experiments employing the temperature-sensitive janB mutation in a double-mutant (bcd, janB) combination allowed us to observe the changes in pattern as a mirror-image geometry was brought into expression and subsequently removed within the bcd, janB double homozygote. These experiments suggest that there are multiple pattern-mechanisms at work with differing kinetics of expression in the ciliate cortex. We discuss how the bcd mutation could influance expression of the janus mutations in light of a model previously proposed to account for the janus phenotype.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
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    Springer
    Pure and applied geophysics 131 (1989), S. 639-685 
    ISSN: 1420-9136
    Keywords: Finite-difference ; finite-element ; scattering ; random heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract This paper reviews applications of the finite-difference and finite-element methods to the study of seismic wave scattering in both simple and complex velocity models. These numerical simulations have improved our understanding of seismic scattering in portions of the earth where there is significant lateral heterogeneity, such as the crust. The methods propagate complete seismic wavefields through highly complex media and include multiply scattered waves and converted phases (e.g.,P toSV, SV toP, body wave to surface wave). The numerical methods have been especially useful in cases of moderate and strong scattering in complex media where multiple scattering becomes important. Progress has been made with numerical methods in understanding how near-surface, low-velocity basin structures scatter surface waves and vertically-incident body waves. The numerical methods have proven useful in evaluating scattering of surface waves and body waves from topography of both the free surface and interfaces buried at depth. Numerical studies have demonstrated the importance of conversions from body waves to surface waves (andvice versa) when lateral heterogeneities and topographic relief are present in the uppermost crust. Recently, several investigations have applied numerical methods to study seismic wave propagation in velocity models which vary randomly in space. This stochastic approach seeks to understand the effects of small-scale complexity in the earth which cannot be resolved deterministically. These experiments have quantified the relationships between the statistical properties of the random heterogeneity and the measurable properties of high-frequency (≥1 Hz) seismograms. These simulations have been applied to the study of many features observed in actual high-frequency seismic waves, including: the amplitude and time decay of seismic coda, the apparent attenuation from scattering, the dispersion of waveforms, and the travel time and waveform variations across arrays of receivers.
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  • 6
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    Springer
    Mathematische Annalen 241 (1979), S. 107-112 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
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    Mathematische Annalen 252 (1980), S. 259-260 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
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    Mathematische Zeitschrift 182 (1983), S. 575-576 
    ISSN: 1432-1823
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 9
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    Immunogenetics 38 (1993), S. 235-237 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Initial observations of low fertility, reduced sexual activity of males, and a high frequency of abnormalities in sperm differentiation of the wild type strain (Sevelen, Zürich) of Drosophila melanogaster, normally used in this laboratory, have lead to a study of this phenomenon and its causes. The abnormalities occur during all spermiogenetic stages and are not unique but are found with much lower frequency in normally fertile flies (Oregon R). Growth of Sevelen flies at high but sublethal temperatures (30°C) results in complete sterility, highly abnormal sperm differentiation, and a failure to recover fertility after return to normal temperatures (25° C) in the time period in which normal flies recover. — The principal factor, or factors, controlling normal sperm differentiation are located on the Y chromosome, but are thus far not precisely localized. Expression of the phenotype is modified by genetic background in which the Y chromosome is found.
    Type of Medium: Electronic Resource
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