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  • 1
    Electronic Resource
    Electronic Resource
    Fate mapping study of the splanchnopleural mesoderm of the 1.5-day-old chick embryo (1995)
    Springer
    Development genes and evolution 204 (1995), S. 392-399 
    Details
    ISSN: 1432-041X
    Keywords: Digestive-tract morphogenesis ; Regionalization ; Vital staining ; Dil ; Fate map
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Various portions of the splanchnopleural mesoderm lateral to the somites of 1.5-day chick embryos were marked in ovo by local injection of Dil, and the distribution of the labelled cells in the digestive-tract mesoderm formed after 3 days' reincubation was analysed. The presumptive area of the digestive organs was confined to bands of splanchnic mesoderm lying lateral to the somites, on both sides, with a width two or three times that between the midline of the embryo and the lateral edge of the somite. Each band generally contributed cells to its own side of the digestive-tract mesoderm, except for the region around the bile duct. The anterior and posterior portion of the pre-gut area contributed cells to the anterior and posterior region of the digestive tract, respectively, but label originating from the portion furthest from the somite took the more ventral and posterior position. Thus, the presumptive areas of the respective digestive organs were located anteroposteriorly in the same order as in the digestive tract with their boundaries lying oblique to the embryonic axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00360484
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  • 2
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    Fate mapping study of the splanchnopleural mesoderm of the 1.5-day-old chick embryo (1995)
    Springer
    Details
    Publication Date: 1995-06-01
    Print ISSN: 0949-944X
    Electronic ISSN: 1432-041X
    Topics: Biology
    Published by Springer
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    PAPER CURRENT
  • 3
    Electronic Resource
    Electronic Resource
    Least squares and integral methods for the spherical harmonic analysis of theSq-field (1989)
    Springer
    Pure and applied geophysics 131 (1989), S. 357-370 
    Details
    ISSN: 1420-9136
    Keywords: Spherical harmonic analysis ; Sq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Spherical harmonic coefficients (SHCs) for the daily magnetic variation fields (solar and lunar) and the main field of the earth are usually estimated by the method of least squares applied to a truncated spherical harmonic series. In this paper, an integral method for computing the SHCs for the solar quiet daily magnetic variation fieldSq is described and applied toSq data for May and June 1965. TheSq SHCs thus derived are then compared with the results obtained using both unweighted and weighted versions of the least squares method. The weighting used tends to orthogonalize the least squares terms. The integral and weighted least squares results agree closely for terms up to order 4 and degree 30, but both disagree considerably for the higher degree terms with the results of the unweighted least squares. Errors introduced by the numerical integration can be shown to be small, hence the disagreement between integral and unweighted least squares coefficient sets arises from improper weighting. Also, it is concluded that discrepancies between the geomagnetic northward and eastward component-derived coefficient sets arise from either time-dependent external sources that produce non-local-time, based fields or nonpotential sources and not from truncation of the spherical harmonic series as has previously been suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00876834
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  • 4
    Electronic Resource
    Electronic Resource
    Appearance of brush-border antigens and sucrase in the allantoic endoderm cultured in recombination with digestive-tract mesenchymes (1984)
    Springer
    Development genes and evolution 193 (1984), S. 211-218 
    Details
    ISSN: 1432-041X
    Keywords: Allantoic endoderm ; Heterotypic differentiation ; Intestinal epithelium ; Cloacal epithelium ; Immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Allantoic endoderm of 3.5-day chick embryos was cultured in recombination with digestive-tract mesenchymes of 6-day chick embryos, and the differentiation of the endoderm was studied, with special attention being given to the appearance of brush-border (BB) antigens and sucrase. Irrespective of the origin of the associated digestive-tract mesenchymes, the allantoic endoderm differentiated into a columnar epithelium, expressing BB antigens and sucrase, and also into a BB antigen-negative pseudostratified or stratified epithelium of cuboidal or columnar cells with PAS or alcian blue staining in the apical portion or a BB antigen-negative stratified squamous epithelium. These results suggest that 3.5-day allantoic endoderm has the potency to differentiate into intestinal and cloacal epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01260341
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  • 5
    Electronic Resource
    Electronic Resource
    Fate mapping study of the endoderm of the 1.5-day-old chick embryo (1996)
    Springer
    Development genes and evolution 205 (1996), S. 225-231 
    Details
    ISSN: 1432-041X
    Keywords: Digestive tract morphogenesis ; Regionalization ; Vital staining ; Dil ; Fate map
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Various portions of the endoderm between the levels of the first and the 10th somite of 1.5-day-old chick embryos were marked by local application of the vital dye Dil, and the fate of marked cells was analyzed after cultivation of the embryos for 2 days in vitro. The presumptive area of digestive tract ranging from the posterior pharynx to the jejunum was found to extend bilaterally from the midline of the 1.5-day embryo with a width two or three times as great as the distance between the midline and the lateral edge of the somite. Either side of this area contributed to the same side of the endodermal tube of digestive tract. The anterior and posterior portions generally contributed to the anterior and posterior regions of the digestive tract, respectively, and the cells originating from the portion farther from the midline took the more ventral and posterior position in the digestive tract endoderm. Most of the presumptive areas of the digestive organs in the endoderm of 1.5-day embryo were located in a more anterior position than those in the splanchnic mesoderm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365800
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  • 6
    Electronic Resource
    Electronic Resource
    Fields of 2-planes on compact simply-connected smooth 4-manifolds (1988)
    Springer
    Mathematische Annalen 280 (1988), S. 687-689 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450085
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  • 7
    Electronic Resource
    Electronic Resource
    Zur Theorie der nichtkommutativen Verbände. I (1959)
    Springer
    Mathematische Annalen 137 (1959), S. 1-8 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01343068
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  • 8
    Electronic Resource
    Electronic Resource
    Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2 (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 431-434 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Inactive aldehyde dehydrogenase-2 (ALDH2) is a well-known biological deterrent of heavy drinking among Asians, although some individuals who have inactive ALDH2 do become alcoholics. Unknown biological mechanisms facilitating the development of the disease may operate in such a way that these individuals overcome adverse reactions, or they may lower the intensity of the reactions. To examine our hypothesis that ethanol-oxidizing isoenzymes have lower catalytic properties in some persons, we investigated polymorphisms of ethanol-oxidizing enzymes that may alter their catalytic activities, viz., alcohol dehydrogenase-2 (ADH2) and -3 (ADH3), and cytochrome P450 2E1 (CYTP2E1), among 80 Japanese alcoholics with inactive ALDH2, 575 alcoholics with active ALDH2, and 461 controls. Although higher ADH2*1 and ADH3*2 allele frequencies were observed in alcoholics than in controls, there was no significant difference in ADH2 and ADH3 genotypes between alcoholics with inactive ALDH2 and alcoholics with active ALDH2. The genotype distributions of CYTP2E1 did not differ among the three groups, indicating no allelic association of the c1/c2 polymorphism of CYTP2E1 with alcoholism. These results suggest that genetic variations in ethanol-oxidizing activities are involved in the development of the disease, but that these variations are not specific in alcoholics with inactive ALDH2, a group at genetically low risk for alcoholism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050067
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  • 9
    Electronic Resource
    Electronic Resource
    Differential binding of peptides substituted at a putative C-terminal anchor residue to I-Ag7β56Hisβ57Ser and I-Ag7β56Proβ57Asp (1998)
    Springer
    Immunogenetics 47 (1998), S. 411-414 
    Details
    ISSN: 1432-1211
    Keywords: Key words IDDM ; NOD ; I-Ag7 ; Peptide motifs ; HLA-DQ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050377
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  • 10
    Electronic Resource
    Electronic Resource
    Identification of the gene variations in human CD22 (1999)
    Springer
    Immunogenetics 49 (1999), S. 280-286 
    Details
    ISSN: 1432-1211
    Keywords: Key words CD22 ; Polymorphism ; Systemic lupus erythematosus ; Rheumatoid arthritis ; Japanese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  CD22, a member of the immunoglobulin superfamily, is a B-cell transmembrane glycoprotein that acts as an accessory-signaling component of the B-cell antigen receptor (BCR). Recent evidence indicating the role of CD22 as a negative regulator of BCR signal transduction prompted us to test the possibility that genetic variations of human CD22 may be associated with autoimmune diseases. In this study, variation screening of the entire CD22 coding region was performed, and possible association with rheumatic diseases was tested, using the genomic DNA from 207 healthy Japanese individuals, 68 patients with systemic lupus erythematosus (SLE), and 119 patients with rheumatoid arthritis (RA). Through the variation screening, seven non-synonymous and four synonymous substitutions were identified. In addition, single base substitutions were found in two introns flanking exon-intron junctions. Among these variations, Q152E substitution within the second extracellular domain was observed with a marginally higher frequency in the patients with SLE (3/68, 4.4%) than that in healthy individuals (1/207, 0.5%) (P=0.048. SLE vs healthy individuals), although this difference was no longer significant after correction for the number of comparisons (Pc=0.62). No significant association was observed between any of the variations and RA. These findings indicate that a number of genetic variants are present in CD22, and suggest that CD22 could be considered a candidate for the susceptibility genes to autoimmune diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050494
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