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  • Springer  (396)
  • 1995-1999  (351)
  • 1965-1969  (45)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Natural selection on the peptide-binding regions of major histocompatibility complex molecules (1995)
    Springer
    Immunogenetics 42 (1995), S. 233-243 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176440
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins (1995)
    Springer
    Immunogenetics 41 (1995), S. 257-262 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An evolutionary analysis of self peptides reported to be bound by HLA class I molecules showed that these peptides are largely derived from proteins that have been highly conserved in the history of mammals. These proteins also often have universal tissue expression and have a higher than average frequency of highly hydrophilic residues. The peptides themselves are generally still more highly conserved than the source proteins and have a higher frequency of highly hydrophobic residues, evidently often derived from conserved hydrophobic cores of the source proteins. These results suggest that the mechanism by which peptides are derived for MHC presentation may preferentially select peptides from conserved protein regions. In the case of parasite-derived peptides, such a mechanism would be adaptive in that it would reduce the likelihood of escape mutants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172149
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  • 3
    Electronic Resource
    Electronic Resource
    Abuse/misuse of non‐prescription drugs (1999)
    Springer
    Pharmacy world & science 21 (1999), S. 251-255 
    Details
    ISSN: 1573-739X
    Keywords: Abuse ; Misuse ; Non‐prescription medicines ; Over‐the‐counter products ; Pharmacist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Aim: To investigate the abuse of non‐prescription (over‐the‐counter; OTC) products in Northern Ireland. Method: A structured questionnaire covering various aspects of OTC drug abuse was mailed to all 509 community pharmacies in Northern Ireland. Results: 253 responses were received (response rate 49.7%) after two mailings. Pharmacists named 112 OTC products they perceived were being abused in Northern Ireland. These were classified into 8 groups, with opioids, antihistamines and laxatives the most frequently reported. The frequency of abuse of all product groups was perceived to be either increasing or static. The number of clients suspected of abuse over a three‐month period ranged from 0 to 700 (median=10, mode=6) with 55% being regular customers. Pharmacists employed several methods to limit patient access to products of abuse. The most common technique was to keep the product out of sight. Others included additional client questioning, providing advice and limiting the quantity of product sold. The majority of respondents agreed their role could be extended to include other methods of dealing with abusers, including participation in harm‐reduction programmes to wean abusers off products. Geographical region and location of pharmacy were not significant factors in the abuse of OTC products. Conclusions: Pharmacists in Northern Ireland perceive abuse and misuse of OTC products to be occurring in practice. Current methods employed for dealing with it are inadequate. Research into methods of effectively dealing with OTC abuse/misuse is required and has commenced on the basis of these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008788726842
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  • 4
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    Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins (1995)
    Springer
    Details
    Publication Date: 1995-03-01
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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    PAPER CURRENT
  • 5
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    Natural selection on the peptide-binding regions of major histocompatibility complex molecules (1995)
    Springer
    Details
    Publication Date: 1995-08-01
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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    PAPER CURRENT
  • 6
    Electronic Resource
    Electronic Resource
    Chemistry Using the Quality Approach (1996)
    Springer
    The chemical educator 1 (1996), S. 1-9 
    Details
    ISSN: 1430-4171
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Chemistry textbooks have traditionally offered a variety of reasons why the study of chemistry is important to citizens of the modern world. This paper presents an approach that encourages students to create their own reasons why chemistry is important, not only to themselves, but for the greater good of the community. The approach was tested on a group of 20 tenth-grade honors chemistry students at a private college-preparatory school in Hawaii. The results show that a strong majority (15) of the students in the class reported that the approach helped them understand the connection between chemistry, themselves, and their community.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00897960031a
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  • 7
    Electronic Resource
    Electronic Resource
    Two tools for integrating geology into ecosystem studies (1995)
    Springer
    Environmental geology 26 (1995), S. 246-251 
    Details
    ISSN: 1432-0495
    Keywords: Ecosystem ; Land management ; Matrix ; Hierarachy ; Geology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Increased interest in understanding ecosystems as a basis for land management requires new approaches for incorporating geology into the process. Limited work performed by geologists to ensure adequate information about geologic interrelationships with the biosphere is available to land managers and other earth scientists. This paper proposes two processes that will aid in increasing the amount and quality of geologic information available to land managers and other earth scientists. First, the geologic integration with ecosystem matrix is a computer data-base format presenting the chemical and physical interrelationships of geology with the biosphere. Second, the geologic terrane land unit hierarchy is an approach to segregating the earth's surface into a hierarchy of land units to simplify applying data-base information to the land.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00770475
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  • 8
    Electronic Resource
    Electronic Resource
    Mineralogical and geochemical signature of mine waste contamination, Tresillian River, Fal Estuary, Cornwall, UK (1997)
    Springer
    Environmental geology 29 (1997), S. 58-65 
    Details
    ISSN: 1432-0495
    Keywords: Key words Mine waste contamination ; Cornwall ; UK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  The mineralized district of SW England was one of the world's greatest mining areas, with mining commencing in the Bronze age, peaking in the 1850s to 1890s, but still continuing to the present day. Consequently, it is not surprising that mining has had a major impact on the environmental geochemistry of SW England. In this study, the mineralogical and geochemical signature of mine waste contamination within the Fal Estuary at Tresillian, Cornwall, has been examined. A pulse of mine waste contamination is recognized at approximately 50 cm below present day sediment surface. Sn, As, Cu, Pb, and Zn are all enriched within this contaminated interval with up to 1800 mg kg–1 Sn, 290 mg kg–1 As, 508 mg kg–1 Pb, 2210 mg kg–1 Zn, and 1380 mg kg–1 Cu. Within this interval, the dominant minerals present include chalcopyrite, arsenopyrite, pyrite, cassiterite, Fe–Ti oxides (ilmenite and ?rutile), wolframite, sphalerite, baryte, zircon, monazite, tourmaline and xenotime. In addition, man-made slag products commonly occur. The exact timing of the release of mine waste into the estuary is poorly constrained, but probably occurred during or immediately following the peak in mining activity in the nearby Camborne-Redruth district, which was between 1853 and 1893. The mine waste may have entered the estuary either via the Tresillian River and its tributaries or via Calenick Creek and the Truro River and/or the Carnon River which flows into Rostronguet Creek.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050104
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  • 9
    Electronic Resource
    Electronic Resource
    Geochemistry and stratigraphic correlation of basalt lavas beneath the Idaho Chemical Processing Plant, Idaho National Engineering Laboratory (1997)
    Springer
    Environmental geology 30 (1997), S. 108-118 
    Details
    ISSN: 1432-0495
    Keywords: Key words Stratigraphy ; Basalt ; Geochemistry ; Snake River Plain aquifer ; Idaho National Engineering Laboratory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Thirty-nine samples of basaltic core were collected from wells 121 and 123, located approximately 1.8 km apart north and south of the Idaho Chemical Processing Plant at the Idaho National Engineering Laboratory. Samples were collected from depths ranging from 15 to 221 m below land surface for the purpose of establishing stratigraphic correlations between these two wells. Elemental analyses indicate that the basalts consist of three principal chemical types. Two of these types are each represented by a single basalt flow in each well. The third chemical type is represented by many basalt flows and includes a broad range of chemical compositions that is distinguished from the other two types. Basalt flows within the third type were identified by hierarchical K-cluster analysis of 14 representative elements: Fe, Ca, K, Na, Sc, Co, La, Ce, Sm, Eu, Yb, Hf, Ta, and Th. Cluster analyses indicate correlations of basalt flows between wells 121 and 123 at depths of approximately 38–40 m, 125–128 m, 131–137 m, 149–158 m, and 183–198 m. Probable correlations also are indicated for at least seven other depth intervals. Basalt flows in several depth intervals do not correlate on the basis of chemical compositions, thus reflecting possible flow margins in the sequence between the wells. Multi-element chemical data provide a useful method for determining stratigraphic correlations of basalt in the upper 1–2 km of the eastern Snake River Plain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050138
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  • 10
    Electronic Resource
    Electronic Resource
    Synonymous and Nonsynonymous Substitution Distances Are Correlated in Mouse and Rat Genes (1998)
    Springer
    Journal of molecular evolution 47 (1998), S. 119-121 
    Details
    ISSN: 1432-1432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006367
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