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  • PANGAEA  (3)
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  • 1
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    (Table 1) Concentrations of polybrominated diphenyl ethers in liver and plasma samples of ringed seals (Phoca hispida) (2009)
    PANGAEA
    In:  Supplement to: Routti, Heli; Letcher, Robert J; Chu, Shaogang; van Bavel, Bert; Gabrielsen, Geir W (2009): Polybrominated diphenyl ethers and their hydroxylated analogues in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Environmental Science & Technology, 43(10), 3494-3499, https://doi.org/10.1021/es900211u
    Details
    Publication Date: 2023-12-13
    Description: The present study investigated the concentrations and patterns of PBDEs and hydroxylated (OH) PBDE analogues in two ringed seal populations: less contaminated Svalbard and more contaminated Baltic Sea. Mean concentration of hepatic sum-PBDE, which was dominated by BDE47, was six times higher in the ringed seals from the Baltic Sea compared to the seals from Svalbard. BDE47/sum-PBDE was higher in the seals from Svalbard compared to that for Baltic seals, while the trend was opposite for BDE153 and 154. The geographical difference in contaminant pattern of PBDEs in ringed seals could be explained by biotransformation via oxidative metabolism and/or by dietary differences. OH-PBDEs were detectable in the majority of plasma samples from both locations, and dominated by bioaccumulation of naturally occurring congeners. Low levels of 3-OH-BDE47 and 4'-OH-BDE49 in the Baltic ringed seals suggested minor oxidative biotransformation of BDE47. In the Baltic seals, BDE153/sum-PBDEs and BDE154/sum-PBDEs increased and BDE28/sum-PBDE decreased with increasing sum-POP concentration, which suggests BDE153 and 154 are more persistent than BDE28. Contrasting diets of the ringed seals in these two locations may influence the PBDE congener pattern due to selective long-range transport and direct effluent emissions to Svalbard and the Baltic, respectively.
    Keywords: Area/locality; Baltic Sea; BalticSea_Bothnia; Biological sample; BIOS; Comment; Event label; Hydroxylated polybrominated diphenyl ethers; International Polar Year (2007-2008); IPY; Lipids; MULT; Multiple investigations; Polybrominated diphenyl ethers; Polybrominated diphenyl ethers, congener BDE-100; Polybrominated diphenyl ethers, congener BDE-138; Polybrominated diphenyl ethers, congener BDE-153; Polybrominated diphenyl ethers, congener BDE-154; Polybrominated diphenyl ethers, congener BDE-183; Polybrominated diphenyl ethers, congener BDE-28; Polybrominated diphenyl ethers, congener BDE-47; Polybrominated diphenyl ethers, congener BDE-66; Polybrominated diphenyl ethers, congener BDE-85; Polybrominated diphenyl ethers, congener BDE-99; Sample amount, subset; Sample type; Sampling date; Species; Species, common name; Svalbard
    Type: Dataset
    Format: text/tab-separated-values, 163 data points
    Location Call Number Expected Availability
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    DATA PANGAEA
  • 2
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    (Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea (2008)
    PANGAEA
    In:  Supplement to: Routti, Heli; Letcher, Robert J; Arukwe, Augustine; van Bavel, Bert; Yoccoz, Nigel G; Chu, Shaogang; Gabrielsen, Geir W (2008): Biotransformation of PCBs in relation to phase I and II xenobiotic-metabolizing enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Environmental Science & Technology, 42(23), 8952-8958, https://doi.org/10.1021/es801682f
    Details
    Publication Date: 2023-12-13
    Description: Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration and pattern of PCBs, the induction of hepatic phase I and II enzymes, and the formation of hydroxy (OH) and methylsulfonyl (CH3SO2=MeSO2) PCB metabolites in two ringed seal (Phoca hispida) populations, which are contrasted by the degree of contamination exposure, that is, highly contaminated Baltic Sea (n = 31) and less contaminated Svalbard (n = 21). Phase I enzymes were measured as ethoxyresorufin-O-deethylation (EROD), benzyloxyresorufin-O-dealkylation (BROD), methoxyresorufin-O-demethylation (MROD), and pentoxyresorufin-O-dealkylation (PROD) activities, and phase II enzymes were measured as uridine diphosphophate glucuronosyl transferase (UDPGT) and glutathione-S-transferase (GST). Geographical comparison, multivariate, and correlation analysis indicated that sum-PCB had a positive impact on Phase I enzyme and GST activities leading to biotransformation of group III (vicinal ortho-meta-H atoms and 〈=1 ortho-chlorine (Cl)) and IV PCBs (vicinal meta-para-H atoms and 〈=2 ortho-Cl). The potential precursors for the main OH-PCBs detected in plasma in the Baltic seals were group III PCBs. MeSO2-PCBs detected in liver were mainly products of group IV PCB metabolism. Both CYP1A- and CYP2B-like enzymes are suggested to be involved in the PCB biotransformation in ringed seals.
    Keywords: Age, relative, number of years; Age, standard deviation; Area/locality; Baltic Sea; BalticSea_Bothnia; Biological sample; BIOS; Event label; Female; Hydroxy-polychlorinated biphenyl; Hydroxy-polychlorinated biphenyl, standard deviation; International Polar Year (2007-2008); IPY; Lipids; Lipids, standard deviation; Male; Methyl sulfone polychlorinated biphenyl; Methyl sulfone polychlorinated biphenyl, standard deviation; MULT; Multiple investigations; Polychlorinated biphenyl; Polychlorinated biphenyl, standard deviation; Sample amount, subset; Sample type; Sampling date; Species; Species, common name; Svalbard
    Type: Dataset
    Format: text/tab-separated-values, 102 data points
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  • 3
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    (Table 1) Concentrations of the main organochlorine pesticides in liver and plasma samples of ringed seals (Phoca hispida) (2009)
    PANGAEA
    In:  Supplement to: Routti, Heli; van Bavel, Bert; Letcher, Robert J; Arukwe, Augustine; Chu, Shaogang; Gabrielsen, Geir W (2009): Concentrations, patterns and metabolites of organochlorine pesticides in relation to xenobiotic phase I and II enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Environmental Pollution, 157(8-9), 2428-2434, https://doi.org/10.1016/j.envpol.2009.03.008
    Details
    Publication Date: 2023-12-13
    Description: The present study investigates the concentrations and patterns of organochlorine pesticides (OCPs) and their metabolites in liver and plasma of two ringed seal populations (Phoca hispida): lower contaminated Svalbard population and more contaminated Baltic Sea population. Among OCPs, p,p'-DDE and sum-chlordanes were the highest in concentration. With increasing hepatic contaminant concentrations and activities of xenobiotic-metabolizing enzymes, the concentrations of 3-methylsulfonyl-p,p'-DDE and the concentration ratios of pentachlorophenol/hexachlorobenzene increased, and the toxaphene pattern shifted more towards persistent Parlar-26 and -50 and less towards more biodegradable Parlar-44. Relative concentrations of the chlordane metabolites, oxychlordane and -heptachlorepoxide, to sum-chlordanes were higher in the seals from Svalbard compared to the seals from the Baltic, while the trend was opposite for cis- and trans-nonachlor. The observed differences in the OCP patterns in the seals from the two populations are probably related to the catalytic activity of xenobiotic-metabolizing enzymes, and also to differences in dietary exposure.
    Keywords: 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene; 4-hydroxy-heptachlorostyrene; Area/locality; Baltic Sea; BalticSea_Bothnia; Biological sample; BIOS; Chlordane; Event label; Hexachlorobenzene; International Polar Year (2007-2008); IPY; Lipids; MULT; Multiple investigations; Organochlorine pesticides; para,para-Dichlorodiphenyldichloroethylene; Sample amount, subset; Sample type; Sampling date; Species; Species, common name; Svalbard; Toxaphene, total
    Type: Dataset
    Format: text/tab-separated-values, 131 data points
    Location Call Number Expected Availability
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    DATA PANGAEA
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