ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
  • 2
    Publication Date: 2007-06-01
    Print ISSN: 1745-3925
    Electronic ISSN: 1745-3933
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2015-08-25
    Description: Motivation: Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) detects genome-wide DNA–protein interactions and chromatin modifications, returning enriched regions (ERs), usually associated with a significance score. Moderately significant interactions can correspond to true, weak interactions, or to false positives; replicates of a ChIP-seq experiment can provide co-localised evidence to decide between the two cases. We designed a general methodological framework to rigorously combine the evidence of ERs in ChIP-seq replicates, with the option to set a significance threshold on the repeated evidence and a minimum number of samples bearing this evidence. Results : We applied our method to Myc transcription factor ChIP-seq datasets in K562 cells available in the ENCODE project. Using replicates, we could extend up to 3 times the ER number with respect to single-sample analysis with equivalent significance threshold. We validated the ‘rescued’ ERs by checking for the overlap with open chromatin regions and for the enrichment of the motif that Myc binds with strongest affinity; we compared our results with alternative methods (IDR and jMOSAiCS), obtaining more validated peaks than the former and less peaks than latter, but with a better validation. Availability and implementation : An implementation of the proposed method and its source code under GPLv3 license are freely available at http://www.bioinformatics.deib.polimi.it/MSPC/ and http://mspc.codeplex.com/ , respectively. Contact : marco.morelli@iit.it Supplementary information: Supplementary Material are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2013-09-17
    Description: We analyse the evolution of colour gradients predicted by the hydrodynamical models of early-type galaxies (ETGs) in Pipino et al., which reproduce fairly well the chemical abundance pattern and the metallicity gradients of local ETGs. We convert the star formation (SF) and metal content into colours by means of stellar population synthetic model and investigate the role of different physical ingredients, as the initial gas distribution and content, and SF , i.e. the normalization of SF rate. From the comparison with high-redshift data, a full agreement with optical rest-frame observations at z   1 is found, for models with low SF , whereas some discrepancies emerge at 1 〈  z  〈 2, despite our models reproduce quite well the data scatter at these redshifts. To reconcile the prediction of these high SF systems with the shallower colour gradients observed at lower z we suggest intervention of one to two dry mergers. We suggest that future studies should explore the impact of wet galaxy merging, interactions with environment, dust content and a variation of the initial mass function from the galactic centres to the peripheries.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2013-06-09
    Description: This paper aims at explaining the two phases in the observed specific star formation rate (sSFR), namely the high (〉3/Gyr) values at z  〉 2 and the smooth decrease since z  = 2. In order to do this, we compare to observations the sSFR evolution predicted by well-calibrated models of chemical evolution for elliptical and spiral galaxies, using the additional constraints on the mean stellar ages of these galaxies (at a given mass). We can conclude that the two phases of the sSFR evolution across cosmic time are due to different populations of galaxies. At z  〉 2, the contribution comes from spheroids: the progenitors of present-day massive ellipticals (which feature the highest sSFR) as well as haloes and bulges in spirals (which contribute with average and lower-than-average sSFR). In each single galaxy, the sSFR decreases rapidly and the star formation stops in 〈1 Gyr. However, the combination of different generations of ellipticals in formation might result in an apparent lack of strong evolution of the sSFR (averaged over a population) at high redshift. The z  〈 2 decrease is due to the slow evolution of the gas fraction in discs, modulated by the gas accretion history and regulated by the Schmidt law. The Milky Way makes no exception to this behaviour.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2015-05-02
    Description: In recent years, the Galactic Centre (GC) region (200 pc in radius) has been studied in detail with spectroscopic stellar data as well as an estimate of the ongoing star formation rate. The aims of this paper are to study the chemical evolution of the GC region by means of a detailed chemical evolution model and to compare the results with high-resolution spectroscopic data in order to impose constraints on the GC formation history. The chemical evolution model assumes that the GC region formed by fast infall of gas and then follows the evolution of α-elements and Fe. We test different initial mass functions (IMFs), efficiencies of star formation and gas infall time-scales. To reproduce the currently observed star formation rate, we assume a late episode of star formation triggered by gas infall/accretion. We find that, in order to reproduce the [α/Fe] ratios as well as the metallicity distribution function observed in GC stars, the GC region should have experienced a main early strong burst of star formation, with a star formation efficiency as high as ~25 Gyr –1 , occurring on a time-scale in the range ~0.1–0.7 Gyr, in agreement with previous models of the entire bulge. Although the small amount of data prevents us from drawing firm conclusions, we suggest that the best IMF should contain more massive stars than expected in the solar vicinity, and the last episode of star formation, which lasted several hundred million years, should have been triggered by a modest episode of gas infall/accretion, with a star formation efficiency similar to that of the previous main star formation episode. This last episode of star formation produces negligible effects on the abundance patterns and can be due to accretion of gas induced by the bar. Our results exclude an important infall event as a trigger for the last starburst.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2014-12-17
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2016-03-24
    Description: According to the current cosmological cold dark matter paradigm, the Galactic halo could have been the result of the assemblage of smaller structures. Here we explore the hypothesis that the classical and ultra-faint dwarf spheroidal satellites of the Milky Way have been the building blocks of the Galactic halo by comparing their [α/Fe] and [Ba/Fe] versus [Fe/H] patterns with the ones observed in Galactic halo stars. The α elements deviate substantially from the observed abundances in the Galactic halo stars for [Fe/H] values larger than –2 dex, while they overlap for lower metallicities. On the other hand, for the [Ba/Fe] ratio, the discrepancy is extended at all [Fe/H] values, suggesting that the majority of stars in the halo are likely to have been formed in situ . Therefore, we suggest that [Ba/Fe] ratios are a better diagnostic than [α/Fe] ratios. Moreover, for the first time we consider the effects of an enriched infall of gas with the same chemical abundances as the matter ejected and/or stripped from dwarf satellites of the Milky Way on the chemical evolution of the Galactic halo. We find that the resulting chemical abundances of the halo stars depend on the assumed infall time-scale, and the presence of a threshold in the gas for star formation. In particular, in models with an infall time-scale for the halo around 0.8 Gyr coupled with a threshold in the surface gas density for the star formation (4 M pc –2 ), and the enriched infall from dwarf spheroidal satellites, the first halo stars formed show [Fe/H]〉–2.4 dex. In this case, to explain [α/Fe] data for stars with [Fe/H]〈–2.4 dex, we need stars formed in dSph systems.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2015-03-26
    Description: We have studied the effects of various initial mass functions (IMFs) on the chemical evolution of the Sagittarius dwarf galaxy (Sgr). In particular, we tested the effects of the integrated galactic initial mass function (IGIMF) on various predicted abundance patterns. The IGIMF depends on the star formation rate and metallicity and predicts less massive stars in a regime of low star formation, as it is the case in dwarf spheroidals. We adopted a detailed chemical evolution model following the evolution of α-elements, Fe and Eu, and assuming the currently best set of stellar yields. We also explored different yield prescriptions for the Eu, including production from neutron star mergers. Although the uncertainties still present in the stellar yields and data prevent us from drawing firm conclusions, our results suggest that the IGIMF applied to Sgr predicts lower [α/Fe] ratios than classical IMFs and lower [hydrostatic/explosive] α-element ratios, in qualitative agreement with observations. In our model, the observed high [Eu/O] ratios in Sgr is due to reduced O production, resulting from the IGIMF mass cut-off of the massive oxygen-producing stars, as well as to the Eu yield produced in neutron star mergers, a more promising site than core-collapse supernovae, although many uncertainties are still present in the Eu nucleosynthesis. We find that a model, similar to our previous calculations, based on the late addition of iron from the Type Ia supernova time-delay (necessary to reproduce the shape of [X/Fe] versus [Fe/H] relations) but also including the reduction of massive stars due to the IGIMF, better reproduces the observed abundance ratios in Sgr than models without the IGIMF.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2016-06-11
    Description: We present a novel approach to draw the synthetic colour–magnitude diagram (CMD) of galaxies, which can provide – in principle – a deeper insight in the interpretation and understanding of current observations. In particular, we ‘light up’ the stars of chemical evolution models, according to their initial mass, metallicity and age, to eventually understand how the assumed underlying galaxy formation and evolution scenario affects the final configuration of the synthetic CMD. In this way, we obtain a new set of observational constraints for chemical evolution models beyond the usual photospheric chemical abundances. The strength of our method resides in the very fine grid of metallicities and ages of the assumed data base of stellar isochrones. In this work, we apply our photochemical model to reproduce the observed CMD of the Sculptor dSph and find that we can reproduce the main features of the observed CMD. The main discrepancies are found at fainter magnitudes in the main sequence turn-off and sub-giant branch, where the observed CMD extends towards bluer colours than the synthetic one; we suggest that this is a signature of metal-poor stellar populations in the data, which cannot be captured by our assumed one-zone chemical evolution model.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...