Publication Date:
2013-02-20
Description:
Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF–DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.
Keywords:
Protein-nucleic acid interaction, Miscellaneous/other
Print ISSN:
0305-1048
Electronic ISSN:
1362-4962
Topics:
Biology
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