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  • 1
    Publication Date: 2020-08-08
    Description: Many ultra-diffuse galaxies (UDGs) have been discovered in the Coma cluster, and there is evidence that some, notably Dragonfly 44, have Milky Way-like dynamical masses despite dwarf-like stellar masses. We used X-ray, ultraviolet (UV), and optical data to investigate the star formation and nuclear activity in the Coma UDGs, and we obtained deep UV and X-ray data (Swift and XMM–Newton) for Dragonfly 44 to search for low-level star formation, hot circumgalactic gas, and the integrated emission from X-ray binaries. Among the Coma UDGs, we find UV luminosities consistent with quiescence but NUV − r colours indicating star formation in the past Gyr. This indicates that the UDGs were recently quenched. The r-band luminosity declines with projected distance from the Coma core. The Dragonfly 44 UV luminosity is also consistent with quiescence, with SFR$lt 6imes 10^{-4} , mathrm{M}_{odot }$ yr−1, and no X-rays are detected down to a sensitivity of 1038 erg s−1. This rules out a hot corona with a $M gt 10^8 , mathrm{M}_{odot }$ within the virial radius, which would normally be expected for a dynamically massive galaxy. The absence of bright, low-mass X-ray binaries is consistent with the expectation from the Galaxy total stellar mass, but it is unlikely if most low-mass X-ray binaries form in globular clusters, as Dragonfly 44 has a very large population. Based on the UV and X-ray analysis, the Coma UDGs are consistent with quenched dwarf galaxies, although we cannot rule out a dynamically massive population.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 2
    Publication Date: 2015-08-06
    Description: The very existence of more than a dozen of high-redshift ( z   4) blazars indicates that a much larger population of misaligned powerful jetted active galactic nucleus (AGN) was already in place when the Universe was 1.5 Gyr old. Such parent population proved to be very elusive, and escaped direct detection in radio surveys so far. High-redshift blazars themselves seem to be failing in producing extended radio lobes, raising questions about the connection between such class and the vaster population of radio galaxies. We show that the interaction of the jet electrons with the intense cosmic microwave background (CMB) radiation explains the lack of extended radio emission in high-redshift blazars and in their parent population, helping to explain the apparently missing misaligned counterparts of high-redshift blazars. On the other hand, the emission from the more compact and more magnetized hotspots are less affected by the enhanced CMB energy density. By modelling the spectral energy distribution of blazar lobes and hotspots, we find that most of them should be detectable by low-frequency deep radio observations, e.g. by LOw-Frequency ARray for radio astronomy and by relatively deep X-ray observations with good angular resolution, e.g. by the Chandra satellite. At high redshifts, the emission of a misaligned relativistic jet, being debeamed, is missed by current large sky area surveys. The isotropic flux produced in the hotspots can be below ~1 mJy and the isotropic lobe radio emission is quenched by the CMB cooling. Consequently, even sources with very powerful jets can go undetected in current radio surveys, and misclassified as radio-quiet AGNs.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 3
    Publication Date: 2015-09-11
    Description: We examine simultaneous X-ray and UV light curves from multi-epoch 8 d XMM–Newton observations of the narrow line Seyfert 1 galaxy 1H 0707–495. The simultaneous observations reveal that both X-ray and UV emission are variable and that the amplitude of the X-ray variations is significantly greater than that of the UV variations in both epochs. Using a discrete correlation function the X-ray and UV light curves were examined for correlation on time-scales up to 7 d. Low-significance (~95 per cent confidence) correlations with the UV leading the X-ray variations are observed. The lack of a significant correlation between the UV and X-ray bands seems consistent with the X-ray source being centrally compact and dominated by light bending close to the black hole. In addition, multiband X-ray light curves were examined for correlations on similar time-scales. Highly significant (〉99.9 per cent confidence) correlations were observed at zero lag consistent with previous studies of this active galactic nucleus.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 4
    Publication Date: 2013-06-07
    Description: Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease. Aberrant alternative splicing of exon 10 in the tau pre-mRNA resulting in an imbalance of tau isoforms is one of the molecular causes of the inherited tauopathy, FTDP-17. We showed previously in heterologous systems that exon 10 inclusion in tau mRNA could be modulated by spliceosome-mediated RNA trans -splicing (SMaRT). Here, we evaluated the potential of trans -splicing RNA reprogramming to correct tau mis-splicing in differentiated neurons in a mouse model of tau mis-splicing, the htau transgenic mouse line, expressing the human MAPT gene in a null mouse Mapt background. Trans -splicing molecules designed to increase exon 10 inclusion were delivered to neurons using lentiviral vectors. We demonstrate reprogramming of tau transcripts at the RNA level after transduction of cultured neurons or after direct delivery and long-term expression of viral vectors into the brain of htau mice in vivo . Tau RNA trans -splicing resulted in an increase in exon 10 inclusion in the mature tau mRNA. Importantly, we also show that the trans -spliced product is translated into a full-length chimeric tau protein. These results validate the potential of SMaRT to correct tau mis-splicing and provide a framework for its therapeutic application to neurodegenerative conditions linked to aberrant RNA processing.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2013-04-03
    Description: We revisit the paradigm of the dependence of jet power on black hole (BH) spin in accreting BH systems. In a previous paper, we showed that the luminosity of compact jets continuously launched due to accretion on to BHs in X-ray binaries (analogous to those that dominate the kinetic feedback from active galactic nuclei) does not appear to correlate with reported BH spin measurements. It is therefore unclear whether extraction of the BH spin energy is the main driver powering compact jets from accreting BHs. Occasionally, BH X-ray binaries produce discrete, transient (ballistic) jets for a brief time over accretion state changes. Here, we quantify the dependence of the power of these transient jets (adopting two methods to infer the jet power) on BH spin, making use of all the available data in the current literature, which include 12 BHs with both measured spin parameters and radio flares over the state transition. In several sources, regular, well-sampled radio monitoring has shown that the peak radio flux differs dramatically depending on the outburst (up to a factor of 1000), whereas the total power required to energize the flare may only differ by a factor of 4 between outbursts. The peak flux is determined by the total energy in the flare and the time over which it is radiated (which can vary considerably between outbursts). Using a Bayesian fitting routine, we rule out a statistically significant positive correlation between transient jet power measured using these methods and current estimates of BH spin. Even when selecting sub-samples of the data that disregard some methods of BH spin measurement or jet power measurement, no correlation is found in all cases.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 6
    Publication Date: 2013-09-08
    Description: Systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are two archetypal systemic autoimmune diseases which have been shown to share multiple genetic susceptibility loci. In order to gain insight into the genetic basis of these diseases, we performed a pan-meta-analysis of two genome-wide association studies (GWASs) together with a replication stage including additional SSc and SLE cohorts. This increased the sample size to a total of 21 109 (6835 cases and 14 274 controls). We selected for replication 19 SNPs from the GWAS data. We were able to validate KIAA0319L ( P = 3.31 x 10 –11 , OR = 1.49) as novel susceptibility loci for SSc and SLE. Furthermore, we also determined that the previously described SLE susceptibility loci PXK ( P = 3.27 x 10 –11 , OR = 1.20) and JAZF1 ( P = 1.11 x 10 –8 , OR = 1.13) are shared with SSc. Supporting these new discoveries, we observed that KIAA0319L was overexpressed in peripheral blood cells of SSc and SLE patients compared with healthy controls. With these, we add three ( KIAA0319L , PXK and JAZF1 ) and one ( KIAA0319L ) new susceptibility loci for SSc and SLE, respectively, increasing significantly the knowledge of the genetic basis of autoimmunity.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 7
    Publication Date: 2016-03-23
    Description: The cosmic X-ray background (CXB) is the total emission from past accretion activity on to supermassive black holes in active galactic nuclei (AGN) and peaks in the hard X-ray band (30 keV). In this paper, we identify a significant selection effect operating on the CXB and flux-limited AGN surveys, and outline how they must depend heavily on the spin distribution of black holes. We show that, due to the higher radiative efficiency of rapidly spinning black holes, they will be over-represented in the X-ray background, and therefore could be a dominant contributor to the CXB. Using a simple bimodal spin distribution, we demonstrate that only 15 per cent maximally spinning AGN can produce 50 per cent of the CXB. We also illustrate that invoking a small population of maximally spinning black holes in CXB synthesis models can reproduce the CXB peak without requiring large numbers of Compton-thick AGN. The spin bias is even more pronounced for flux-limited surveys: 7 per cent of sources with maximally spinning black holes can produce half of the source counts. The detectability for maximum spin black holes can be further boosted in hard (〉10 keV) X-rays by up to ~60 per cent due to pronounced ionized reflection, reducing the percentage of maximally spinning black holes required to produce half of the CXB or survey number counts further. A host of observations are consistent with an over-representation of high-spin black holes. Future NuSTAR and ASTRO-H hard X-ray surveys will provide the best constraints on the role of spin within the AGN population.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 8
    Publication Date: 2016-01-02
    Description: We present coordinated multiwavelength observations of the high Galactic latitude ( b  = +50°) black hole X-ray binary (BHXB) Swift J1357.2–0933 in quiescence. Our broad-band spectrum includes strictly simultaneous radio and X-ray observations, and near-infrared, optical, and ultraviolet data taken 1–2 d later. We detect Swift J1357.2–0933 at all wavebands except for the radio ( f 5 GHz 〈 3.9 μJy beam –1 ; 3 rms ). Given current constraints on the distance (2.3–6.3 kpc), its 0.5–10 keV X-ray flux corresponds to an Eddington ratio L X / L Edd  = 4  x  10 –9 –3  x  10 –8 (assuming a black hole mass of 10 M ). The broad-band spectrum is dominated by synchrotron radiation from a relativistic population of outflowing thermal electrons, which we argue to be a common signature of short-period quiescent BHXBs. Furthermore, we identify the frequency where the synchrotron radiation transitions from optically thick-to-thin ( b 2–5  x  10 14  Hz), which is the most robust determination of a ‘jet break’ for a quiescent BHXB to date. Our interpretation relies on the presence of steep curvature in the ultraviolet spectrum, a frequency window made observable by the low amount of interstellar absorption along the line of sight. High Galactic latitude systems like Swift J1357.2–0933 with clean ultraviolet sightlines are crucial for understanding black hole accretion at low luminosities.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 9
    Publication Date: 2016-09-17
    Description: Gene expression measurements represent the most important source of biological data used to unveil the interaction and functionality of genes. In this regard, several data mining and machine learning algorithms have been proposed that require, in a number of cases, some kind of data discretization to perform the inference. Selection of an appropriate discretization process has a major impact on the design and outcome of the inference algorithms, as there are a number of relevant issues that need to be considered. This study presents a revision of the current state-of-the-art discretization techniques, together with the key subjects that need to be considered when designing or selecting a discretization approach for gene expression data.
    Print ISSN: 1467-5463
    Electronic ISSN: 1477-4054
    Topics: Biology , Computer Science
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  • 10
    Publication Date: 2015-04-23
    Description: A multi-epoch, multi-instrument analysis of the Seyfert 1 galaxy HE 0436–4717 is conducted using optical to X-ray data from XMM–Newton and Swift (including the Burst Alert Telescope). Fitting of the UV-to-X-ray spectral energy distribution shows little evidence of extinction and the X-ray spectral analysis does not confirm previous reports of deep absorption edges from O  viii . HE 0436–4717 is a ‘bare' Seyfert with negligible line-of-sight absorption making it ideal to study the central X-ray emitting region. Three scenarios were considered to describe the X-ray data: partial covering absorption, blurred reflection, and soft Comptonization. All three interpretations describe the 0.5–10.0 keV spectra well. Extrapolating the models to $100{\rm \thinspace keV}$ results in poorer fits for the partial covering model. When also considering the rapid variability during one of the XMM–Newton observations, the blurred reflection model appears to describe all the observations in the most self-consistent manner. If adopted, the blurred reflection model requires a very low iron abundance in HE 0436–4717. We consider the possibilities that this is an artefact of the fitting process, but it appears possible that it is intrinsic to the object.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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