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  • 1
    Publication Date: 2016-07-06
    Description: The discovery of actionable targets is crucial for targeted therapies and is also a constituent part of the drug discovery process. The success of an intervention over a target depends critically on its contribution, within the complex network of gene interactions, to the cellular processes responsible for disease progression or therapeutic response. Here we present PathAct, a web server that predicts the effect that interventions over genes (inhibitions or activations that simulate knock-outs, drug treatments or over-expressions) can have over signal transmission within signaling pathways and, ultimately, over the cell functionalities triggered by them. PathAct implements an advanced graphical interface that provides a unique interactive working environment in which the suitability of potentially actionable genes, that could eventually become drug targets for personalized or individualized therapies, can be easily tested. The PathAct tool can be found at: http://pathact.babelomics.org .
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 2
    Publication Date: 2015-05-20
    Description: We present a study of the molecular CO gas and mid/far-infrared radiation arising from the environment surrounding the Wolf–Rayet (WR) star 130. We use the multiwavelength data to analyse the properties of the dense gas and dust, and its possible spatial correlation with that of young stellar objects (YSOs). We use 12 CO J =1–0 data from the Five College Radio Astronomy Observatory survey as tracer of the molecular gas, and mid/far-infrared data from the recent Wide-Field Infrared Survey Explorer (WISE) and Herschel space surveys to study the dust continuum radiation and to identify a population of associated candidate YSOs. The spatial distribution of the molecular gas shows a ring-like structure very similar to that observed in the H i  gas, and over the same velocity interval. The relative spatial distribution of the H i  and CO components is consistent with a photodissociation region. We have identified and characterized four main and distinct molecular clouds that create this structure. Cold dust is coincident with the dense gas shown in the CO measurements. We have found several young stellar object candidates that lie along the regions with the highest gas column density, and suggest that they are spatially correlated with the shell. These are indicative of regions of star formation induced by the strong wind and ionization of the WR star.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 3
    Publication Date: 2013-02-13
    Description: Tourmaline occurs in peraluminous granites from the Central Iberian Zone associated with two main AFM mineral assemblages: (1) muscovite + biotite ± cordierite ± andalusite in the Araya-type granites; (2) muscovite ± biotite ± garnet in leucogranites from the Alamo complex. When tourmaline is dominant, biotite is an accessory or absent, and vice versa. We present field and petrographic relations, mineral chemistry, and geochemical data for tourmaline-bearing and tourmaline-free granitic rocks from various localities in the Central Iberian Zone. Compositional phase diagrams are used to evaluate the factors controlling the occurrence of tourmaline relative to biotite in granitic rocks, with particular emphasis on the relationships between mineral assemblage and whole-rock chemistry and its petrological implications. Although tourmaline stability in felsic magmas depends on the interplay between rates of changing environmental conditions such as bulk composition, T, aH 2 O, and fO 2 , the principal factor dictating tourmaline formation is the B content of the melt, judging from phase relations. In short, regardless of other variables, granitic melts have to surpass a critical boron threshold to achieve tourmaline saturation. Experimental constraints, combined with petrographic and geochemical data, suggest minimum boron contents in the range of ~500–3000 µg g –1 (depending on temperature) to saturate melt in tourmaline. Acting in concert with boron content, other variables such as Al 2 O 3 , mafic components, T, fO 2 , and so on, control not only the formation of tourmaline during melt crystallization, but also the magnitude of boron loss from the magma to the surrounding rocks. The analysis of phase relations suggests that tourmaline granites usually form units distinct from biotite granites because common granitic melts have restricted accessibility to the three-phase Tur–Bt–Ms field.
    Print ISSN: 0022-3530
    Electronic ISSN: 1460-2415
    Topics: Geosciences
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  • 4
    Publication Date: 2020-04-30
    Description: Massive stars leave their imprint on the interstellar medium as they radiate their energy and undergo episodes of mass ejection throughout their lives. In this paper, we analyse the case of the Wolf–Rayet star WR16 combining archival multiwavelength data with new molecular observations obtained with the Atacama Submillimeter Telescope Experiment (ASTE). Our results suggest that during the main-sequence phase, WR16 swept up the surrounding gas creating a molecular structure (which we call Component 1) which also contains very cold dust observed in the infrared band. In a subsequent stage of evolution, as an LBV, the star underwent mass eruptions that were later overrun by the fast winds of the current WR phase. The final result is the round nebula revealed by the optical and IR images, and the molecular clumps detected. We have also computed the peculiar velocity of WR16 using Gaia data and, accordingly, confirm it as a runaway star. We propose that several features observed in different wavelengths can be explained under a bow-shock scenario linked to the high velocity of WR16.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 5
    Publication Date: 2014-04-20
    Description: Herschel far-infrared continuum data obtained as part of the Hi-GAL survey have been used, together with the GLIMPSE 8 μm and MIPSGAL 24 μm data, to attempt the first 3D-decomposition of dust emission associated with atomic, molecular and ionized gas at 15 arcmin angular resolution. Our initial test case is a 2 2 square degrees region centred on ( l , b ) = (30°, 0°), a direction that encompasses the origin point of the Scutum–Crux Arm at the tip of the Galactic Bar. Coupling the IR maps with velocity maps specific for different gas phases (H i 21cm, 12 CO and 13 CO, and radio recombination lines), we estimate the properties of dust blended with each of the gas components and at different Galactocentric distances along the line of sight (LOS). A statistical Pearson's coefficients analysis is used to study the correlation between the column densities estimated for each gas component and the intensity of the IR emission. This analysis provides evidence that the 2 2 square degree field under consideration is characterized by the presence of a gas component not accounted for by the standard tracers, possibly associated with warm H 2 and cold H i . We demonstrate that the IR radiation in the range 8 〈  〈 500 μm is systematically dominated by emission originating within the Scutum–Crux Arm. By applying an inversion method, we recover the dust emissivities associated with atomic, molecular and ionized gas. Using the DustEM model, we fit the spectral energy distributions for each gas phase, and find average dust temperatures of T d,H i  = 18.82 ± 0.47 K, T d,H 2  = 18.84 ± 1.06 K and T d,H ii  = 22.56 ± 0.64 K, respectively. We also obtain an indication for polycyclic aromatic hydrocarbons depletion in the diffuse ionized gas. We demonstrate the importance of including the ionized component in 3D-decompositions of the total IR emission. However, the main goal of this work is to discuss the impact of the missing column density associated with the dark gas component on the accurate evaluation of the dust properties, and to shed light on the limitations of the inversion method approach when this is applied to a small section of the Galactic plane and when the working resolution allows sufficient de-blending of the gas components along the LOS.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 6
    Publication Date: 2014-04-15
    Description: We present a multiwavelength analysis of the nebula around the candidate luminous blue variable G79.29+0.46. The study is based on our radio observations performed at the Expanded Very Large Array and at the Green Bank Telescope and on archival infrared data sets, including recent images obtained by the Herschel Space Observatory . We confirm that the radio central object is characterized by a stellar wind and we derive a current mass-loss rate of about 1.4 10 –6 M yr –1 . We find the presence of a dusty compact envelope close to the star, with a temperature between ~40 and 1200 K. We estimate for the outer ejecta an ionized gas mass of 1.51 M and a warm (60–85 K) dust mass of 0.02 M . Diagnostics of the far-infrared spectra indicate the presence of a photodissociation region around the ionized gas. Finally, we model the nebula with the photoionization code cloudy , using as input parameters those estimated from our analysis. We find for the central star a luminosity of 10 5.4 L and an effective temperature of 20.4 kK.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 7
    Publication Date: 2013-10-29
    Description: Hypertension, the most frequently diagnosed clinical condition world-wide, predisposes individuals to morbidity and mortality, yet its underlying pathological etiologies are poorly understood. So far, a large number of quantitative trait loci (QTLs) have been identified in both humans and animal models, but how they function together in determining overall blood pressure (BP) in physiological settings is unknown. Here, we systematically and comprehensively performed pair-wise comparisons of individual QTLs to create a global picture of their functionality in an inbred rat model. Rather than each of numerous QTLs contributing to infinitesimal BP increments, a modularized pattern arises: two epistatic ‘blocks’ constitute basic functional ‘units’ for nearly all QTLs, designated as epistatic module 1 (EM1) and EM2. This modularization dictates the magnitude and scope of BP effects. Any EM1 member can contribute to BP additively to that of EM2, but not to those of the same module. Members of each EM display epistatic hierarchy, which seems to reflect a related functional pathway. Rat homologues of 11 human BP QTLs belong to either EM1 or EM2. Unique insights emerge into the novel genetic mechanism and hierarchy determining BP in the Dahl salt-sensitive SS/Jr (DSS) rat model that implicate a portion of human QTLs. Elucidating the pathways underlying EM1 and EM2 may reveal the genetic regulation of BP.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2013-12-27
    Description: We report the radio observations of a subsample of the 428 Galactic compact bubbles discovered at 24 μm with the MIPSGAL survey. Pervasive through the entire Galactic plane, these objects are thought to be different kinds of evolved stars. The very large majority of the bubbles (~70 per cent) are however not yet classified. We conducted radio observations with the Expanded Very Large Array at 6 and 20 cm in order to obtain the spectral index of 55 bubbles. We found that at least 70 per cent of the 31 bubbles for which we were effectively able to compute the spectral index (or its lower limit) are likely to be thermal emitters. We were also able to resolve some bubbles, obtaining that the size of the radio nebula is usually similar to the IR size, although our low resolution (with respect to IR images) did not allow further morphological studies. Comparisons between radio flux densities and IR archive data from Spitzer and IRAS suggest that at least three unclassified bubbles can be treated as planetary nebula candidates.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 9
    Publication Date: 2013-12-19
    Description: This article develops an evolutionary framework of regional resilience with a primary focus on the structural properties of local knowledge networks. After presenting the network-based rationales of growth and structuring of clusters, we analyze under which structural conditions a regional cluster can achieve short-run competitiveness without compromising long-run resilience capabilities. We show that the properties of degree distribution (the level of hierarchy) and degree correlation (the level of structural homophily) of regional knowledge networks should be studied to understand how clusters succeed in combining technological lock-in with regional lock-out. We propose simple statistical measures of cluster structuring to highlight these properties and discuss the results in a policy-oriented analysis. We conclude showing that policies for regional resilience should focus on ex-ante regional diagnosis and targeted interventions on particular missing links, rather than ex-postmyopic applications of policies based on an unconditional increase of network relational density.
    Keywords: B52 - Institutional ; Evolutionary, D85 - Network Formation and Analysis: Theory, O33 - Technological Change: Choices and Consequences ; Diffusion Processes, R11 - Regional Economic Activity: Growth, Development, and Changes, R12 - Size and Spatial Distributions of Regional Economic Activity
    Print ISSN: 1468-2702
    Electronic ISSN: 1468-2710
    Topics: Geography , Economics
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  • 10
    Publication Date: 2014-03-08
    Description: The biomass, production and consumption of phytoplankton, bacteria and zooplankton in a shallow Danish estuary (Limfjord) were analysed during a 9-day period. The water column changed between stratified and mixed conditions which influenced the dominant processes in the pelagic system. During strong stratification, phytoplankton was mainly controlled by microzooplankton grazing. A mixing event, which homogenized the water column, possibly provided food to a mussel-dominated benthic community. Concomitantly, zooplankton feeding and reproduction decreased. However, the nutrient input to the upper part of the water column during mixing and the subsequent stabilization provided the ideal conditions for the recovery of phytoplankton from the loss processes from previous days. Microzooplankton, which was also a significant consumer of bacteria throughout the sampling period, was not the only consumer controlling phytoplankton. The microbial food web was an important route for total plankton carbon during the study. However, the shorter food web increased in importance during mixing, possibly due to stronger benthic–pelagic coupling than during stratified periods. Stratification-mixing cycles, occurring during short-time periods, should be a key mechanism maintaining the benthic and pelagic communities in this shallow water system.
    Print ISSN: 0142-7873
    Electronic ISSN: 1464-3774
    Topics: Biology
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