ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2016-01-08
    Description: It is hoped that through the cultivation of a crew of volunteer citizen seismologists, public involvement could be encouraged and the discovery and inquiry into earthquake knowledge could be promoted. These volunteers can contribute to data collection, analysis, and reporting, and have the potential to greatly improve the emergency response to earthquakes. The Citizen Seismologists in Taiwan Project (CSTaiwan) is designed to elevate the quality of earthquake science education by incorporating earthquake and tsunami stories and educational earthquake games into traditional school curricula. The project aims to build a cloud-based computing service incorporating an earthquake school (i.e., a website for online learning) where teachers can easily teach their students about earthquakes and children can learn about earthquakes in a fun environment. Here we demonstrate how students perform P - and S -wave picking and measure seismic intensity through an interactive learning platform, how scientists and school teachers work together, and how we create a near-real-time earthquake games competition to facilitate continuous learning while making earthquake science fun. We also develop 49 questions associated with participants’ preknowledge, attitude, and skills in earthquake sciences, called Citizen Seismological Literacy (CSL). The CSL model may serve as an example to quantify citizen’s background in earthquake sciences and could be applied as a framework for seismologists around the world who wish to approach the public for educational purposes, while considering promoting the public’s seismologic literacy.
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2015-10-10
    Description: Huntington's disease (HD) is an autosomal-dominant degenerative disease caused by a cytosine-adenine-guanine trinucleotide expansion in the Huntingtin ( htt ) gene. The most vulnerable brain areas to mutant HTT-evoked toxicity are the striatum and cortex. In spite of the extensive efforts that have been devoted to the characterization of HD pathogenesis, no disease-modifying therapy for HD is currently available. The A 2A adenosine receptor (A 2A R) is widely distributed in the brain, with the highest level observed in the striatum. We previously reported that stimulation of the A 2A R triggers an anti-apoptotic effect in a rat neuron-like cell line (PC12). Using a transgenic mouse model (R6/2) of HD, we demonstrated that A 2A R-selective agonists effectively ameliorate several major symptoms of HD. In the present study, we show that human iPSCs can be successfully induced to differentiate into DARPP32-positive, GABAergic neurons which express the A 2A R in a similar manner to striatal medium spiny neurons. When compared with those derived from control subjects (CON-iPSCs), these HD-iPSC-derived neurons exhibited a higher DNA damage response, based on the observed expression of H2AX and elevated oxidative stress. This is a critical observation, because oxidative damage and abnormal DNA damage/repair have been reported in HD patients. Most importantly, stimulation of the A 2A R using selective agonists reduced DNA damage and oxidative stress-induced apoptosis in HD-iPSC-derived neurons through a cAMP/PKA-dependent pathway. These findings support our hypothesis that human neurons derived from diseased iPSCs might serve as an important platform to investigate the beneficial effects and underlying mechanisms of A 2A R drugs.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2016-09-07
    Description: On 2016 February 6 the South Taiwan earthquake ( M w 6.4) occurred in the Meinong District of Kaohsiung, southern Taiwan, at a depth of 17 km. It caused 117 fatalities and widespread damage to infrastructures, especially in the Tainan city. To clarify the generating mechanism of this damaging earthquake, we determined high-resolution 3-D images of P - and S -wave velocity ( V P , V S ) and Poisson's ratio ( ) in the epicentral area. We used 105 712 P - and 61 250 S -wave arrival times of 8279 local earthquakes (1.5 ≤ M ≤ 6.4) recorded at 41 seismic stations in South Taiwan during 2000–2011. In the upper crust (depth ≤ 10 km), the most remarkable feature is low- V P , low- V S and high- anomalies in areas with known active faults in the southwestern and easternmost parts of Taiwan. In contrast, high- V P , high- V S and low- anomalies become dominant in the lower crust. The hypocentre of the 2016 South Taiwan earthquake is located in a boundary zone where seismic velocity and Poisson's ratio change drastically in both the horizontal and vertical directions. Furthermore, the hypocentre is underlain by a vertically elongated high- anomaly at depths of 23–40 km, which may reflect ascending fluids from the upper (or uppermost) mantle. The low- V and high- anomalies in the upper crust coincide with areas of low heat flow, negative Bouguer gravity anomaly, and low magnetotelluric resistivity, which may reflect crustal fluids contained in the young fold-and-thrust belt. These results suggest that the 2016 South Taiwan earthquake was triggered by ascending fluids from dehydration of the subducting Eurasian slab, invading into active faults with a high loading rate.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2014-05-01
    Description: In this paper, we deal with the exact circular string matching problem (abbreviated as ECSM). Given a string P = p 1 p 2 ··· p m , a string P ( i ) = p i p i +1 ··· p m p 1 ··· p i –1 , for 1 ≤ i ≤ m , is a circular string of P . Given a text string T = t 1 t 2 ··· t n and a pattern P , the ECSM problem is to find all occurrences of P ( i ) in text T for 1 ≤ i ≤ m . This paper proposes two algorithms that perform searching of a circular string on text using the bit-parallel technique. Our algorithms use only the composition of bitwise-logical operations and basic arithmetic operations, and apply this technique to solve the problem. These algorithms are given names CSBNDM and CSBNDN q , respectively. We give several experiments to verify that they have good performance for random strings and DNA sequences.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2013-03-03
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...