ALBERT

Description: This paper presents a Riemannian trust region algorithm for unconstrained optimization problems with locally Lipschitz objective functions defined on complete Riemannian manifolds. To this end we define a function $\Phi :TM\rightarrow \mathbb {R}$ on the tangent bundle $TM$ , and at the $k$ th iteration, using the restricted function $\Phi |_{T_{x_k}M}$ , where $T_{x_k}M$ is the tangent space at $x_k$ , a local model function $Q_k$ that carries both first- and second-order information for the locally Lipschitz objective function $f:M\rightarrow \mathbb {R}$ on a Riemannian manifold $M$ , is defined and minimized over a trust region. We establish the global convergence of the proposed algorithm. Moreover, using the Riemannian $\varepsilon $ -subdifferential, a suitable model function is defined. Numerical experiments illustrate our results.

Description: Visual refractive errors (REs) are complex genetic traits with a largely unknown etiology. To date, genome-wide association studies (GWASs) of moderate size have identified several novel risk markers for RE, measured here as mean spherical equivalent (MSE). We performed a GWAS using a total of 7280 samples from five cohorts: the Age-Related Eye Disease Study (AREDS); the KORA study (‘Cooperative Health Research in the Region of Augsburg’); the Framingham Eye Study (FES); the Ogliastra Genetic Park-Talana (OGP-Talana) Study and the Multiethnic Study of Atherosclerosis (MESA). Genotyping was performed on Illumina and Affymetrix platforms with additional markers imputed to the HapMap II reference panel. We identified a new genome-wide significant locus on chromosome 16 (rs10500355, P = 3.9 x 10 –9 ) in a combined discovery and replication set (26 953 samples). This single nucleotide polymorphism (SNP) is located within the RBFOX1 gene which is a neuron-specific splicing factor regulating a wide range of alternative splicing events implicated in neuronal development and maturation, including transcription factors, other splicing factors and synaptic proteins.

Description: In small-scale combustors, the ratio of area to the combustor volume increases and hence heat loss from the combustor’s wall is significantly enhanced and flame quenching occurs. To solve this problem, non-premixed vortex flow is employed to stabilize flames in a meso-scale combustion chamber to generate small-scale power or thrust for propulsion systems. In this experimental investigation, the effects of thermal recuperation on the characteristics of asymmetric non-premixed vortex combustion are studied. The exhaust gases temperature, emissions and the combustor wall temperature are measured to evaluate thermal and emitter efficiencies. The results illustrate that in both combustors (with/without thermal recuperator), by increasing the combustion air mass flowrate, the wall temperature increases while the wall temperature of combustor with thermal recuperator is higher. The emitter efficiency calculated based on the combustor wall temperature is significantly increased by using thermal recuperator. Thermal efficiency of the combustion system increases up to 10% when thermal recuperator is employed especially in moderate Reynolds numbers (combustion air flow rate is 120 mg/s).

Description: A new strategy was applied to develop nano-quasicrystalline phase in well-known AlNiCo ternary system. This approach was based on electroless Ni-P plating of the starting powders and subsequent ball milling in a protective atmosphere without additional annealing or sintering processes. Microstructural evolution and phase transformation of both raw and coated particles were analyzed by scanning electron microscope (SEM) and X-ray diffraction (XRD), respectively. After 360 min of mechanical alloying, the peaks demonstrating the formation of nano-quasicrystalline phase appeared in XRD pattern of the coated powders, while those in mechanically alloyed raw powders remained mostly unchanged. The formation of nano-quasicrystalline phase in the vicinity of the primary elements was also confirmed by the corresponding selected area diffraction patterns, and images generated by transmission electron microscope (TEM).

Description: At present, university professors lack the tools to know which is the most sustainable activity and/or strategy that should be incorporated into large-group theoretical classes in order to improve our students’ learning process whilst taking each scenario into account. These scenarios have different order thinking levels, numbers of students, available time, classroom size and professor skills, among other factors to consider. In architecture schools we have this problem in theoretical lectures. This project has developed and applied a new multi-criteria decision making tool incorporating a mathematical algorithm in order to choose the best set of active learning activities for each case for these lectures in architectural technology courses. This process has relied on seminars involving experts and the use of The Integrated Value Model for Sustainable Assessment. This tool has been very useful to solve the aforementioned problems because architecture professors have been able to choose the most sustainable activity for each scenario considering the alternative sustainability indexes. This first application has been highly useful to assist professors to incorporate active learning methodologies in their classes and to promote lecturers’ management of their course contents and time. Future improved versions of this tool will increase its interactivity and broaden its scope.

Description: This paper focuses on the design of a distribution network problem in a three-tiered supply chain under uncertainty. The objective is to determine the optimal number, locations and capacities of plants and warehouses to minimize the overall network costs over a variety of economic growth scenarios. For this purpose, a mixed integer linear programming model is extended in a robust optimization framework and then three heuristic approaches based on genetic and memetic algorithms and a mathematical programming approach are used to solve this problem. The effectiveness of the proposed heuristics and the trade-off between model robustness and solution robustness is investigated and directions for further researches are presented.

Description: The 2003 Bam, Iran, earthquake ( M w  = 6.6) was recorded by the BAM accelerometer station. Since the causative fault was located just below the city, the accelerometer recorded the main shock, a foreshock and several local aftershocks. To study the scenario of rupturing, we simulated all components of the observed main shock waveform via the empirical Green's function method. 28 selected aftershocks and the single foreshock are used to simulate the main shock in the frequency range of 0.5–5 Hz. Since the events were very close to the station, some small events may not have similar path effects to the main shock. Therefore, it is essential to employ some appropriate changes to the waveforms to alleviate path difference effects. The starting point of the rupture is identified in the centre of the strong motion generation area and is located approximately 5 km south of the BAM station and in depth of about 7 km. The horizontal simulated components imply that the main shock was located west of the BAM station. In contrast, significant variation in the ratio of amplitudes in EW and NS components may be used to discuss the possibility of dissimilarity in the focal mechanism of the small events. Most aftershocks with similar mechanisms to the main shock, that is similar EW/NS maximum amplitude ratio, have capacity to simulate certain peaks of their horizontal components. However, some small events with different mechanisms are only able to simulate the peaks of up to one horizontal component. Some changes were applied to the empirical Green's function method to incorporate two small events by using a combined fault model. While the two aftershocks have different mechanisms, some combinations may improve simulations. The rupture initiating point at the middle of the fault plane and improved simulations by combination of two fault surfaces with different focal mechanisms may suggest a bilateral rupture and combination of two focal mechanisms for the main shock of the Bam earthquake.

Description: This study evaluates the potential of carbon dioxide-enhanced oil recovery (CO2-EOR) to reduce greenhouse gas emissions without compromising oil production goals. A novel, dynamic carbon lifecycle analysis (d-LCA) was developed and used to understand the evolution of the environmental impact (CO2 emissions) and mitigation (geologic CO2 storage) associated with an expanded carbon capture, utilization and storage (CCUS) system, from start to closure of operations. EOR operational performance was assessed through CO2 utilization rates, which relate usage of CO2 to oil production. Because field operational strategies have a significant impact on reservoir engineering parameters that affect both CO2 storage and oil production (e.g., sweep efficiency, flood conformance, fluid saturation distribution), we conducted a scenario analysis that assessed the operational and environmental performance of four common and novel CO2-EOR field development strategies. Each scenario was evaluated with and without stacked saline carbon storage, an EOR/storage combination strategy where excess CO2 from the recycling facility is injected into an underlying saline aquifer for long-term carbon storage. The dynamic interplay between operational and environmental performance formed the basis of our CCUS technology analysis. The results showed that all CO2-EOR evaluated scenarios start operating with a negative carbon footprint and, years into the project, transitioned into operating with a positive carbon footprint. The transition points were significantly different in each scenario. Water-alternating-gas (WAG) was identified as the CO2 injection strategy with the highest potential to co-optimize EOR and carbon storage goals. The results provide an understanding of the evolution of the system’s net carbon balance in all four field development strategies studied. The environmental performance can be significantly improved with stacked storage, where a negative carbon footprint can be maintained throughout the life of the operation in most of the injection scenarios modelled. This information will be useful to CO2-EOR operators seeking value in storing more CO2 through a carbon credit program (e.g., the 45Q carbon credit program in the USA). Most importantly, this study serves as confirmation that CO2-EOR can be operationally designed to both enhance oil production and reduce greenhouse gas emissions into the atmosphere.

Description: Background: Alpinia officinarum Hance is both an herbal medicine and a condiment, and generally has different cultivars such as Zhutou galangal and Fengwo galangal. The appearance of these A. officinarum cultivars is similar, but their chemical composition and quality are different. It is therefore important to discriminate between different A. officinarum plants to ensure the consistency of the efficacy of the medicine. Therefore, we used an electronic nose (E-nose) to explore the differences in odor information between the two cultivars for fast and robust discrimination. Methods: Odor and volatile components of all A. officinarum samples were detected by the E-nose and gas chromatography-mass spectrometry (GC-MS), respectively. The E-nose sensors and GC-MS data were analyzed respectively by principal component analysis (PCA), the correlation between E-nose sensors and GC-MS data were analyzed by partial least squares (PLS). Results: It was found that Zhutou galangal and Fengwo galangal can be discriminated by combining the E-nose with PCA, and the E-nose sensors S2, S6, S7, S9 were important sensors for distinguishing different cultivars of A. officinarum. A total of 56 volatile components of A. officinarum were identified by the GC-MS analysis, and the composition and content of the volatile components from the two different A. officinarum cultivars were different, in particular the relative contents of 1,8-cineole and α-farnesene. The classification result by PCA analysis based on GC-MS data was consistent with the E-nose results. The PLS analysis demonstrated that the volatile terpene, alcohol and ester components primarily interacted with the sensors S2 and S7, indicating that particular E-nose sensors were highly correlated with some aroma constituents. Conclusions: Combined with advanced chemometrics, the E-nose detection technology can discriminate two cultivars of A. officinarum, with GC-MS providing support to determine the material basis of the E-nose sensors’ response.

Description: The sequencing of ancient DNA samples provides a novel way to find, characterize, and distinguish exogenous genomes of endogenous targets. After sequencing, computational composition analysis enables filtering of undesired sources in the focal organism, with the purpose of improving the quality of assemblies and subsequent data analysis. More importantly, such analysis allows extinct and extant species to be identified without requiring a specific or new sequencing run. However, the identification of exogenous organisms is a complex task, given the nature and degradation of the samples, and the evident necessity of using efficient computational tools, which rely on algorithms that are both fast and highly sensitive. In this work, we relied on a fast and highly sensitive tool, FALCON-meta, which measures similarity against whole-genome reference databases, to analyse the metagenomic composition of an ancient polar bear (Ursus maritimus) jawbone fossil. The fossil was collected in Svalbard, Norway, and has an estimated age of 110,000 to 130,000 years. The FASTQ samples contained 349 GB of nonamplified shotgun sequencing data. We identified and localized, relative to the FASTQ samples, the genomes with significant similarities to reference microbial genomes, including those of viruses, bacteria, and archaea, and to fungal, mitochondrial, and plastidial sequences. Among other striking features, we found significant similarities between modern-human, some bacterial and viral sequences (contamination) and the organelle sequences of wild carrot and tomato relative to the whole samples. For each exogenous candidate, we ran a damage pattern analysis, which in addition to revealing shallow levels of damage in the plant candidates, identified the source as contamination.