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  • 1
    Publication Date: 2009-11-27
    Description: Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial microenvironments in which to study and instruct stem-cell fate both in culture and in vivo. Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908011/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908011/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lutolf, Matthias P -- Gilbert, Penney M -- Blau, Helen M -- AG009521/AG/NIA NIH HHS/ -- AG020961/AG/NIA NIH HHS/ -- CA09151/CA/NCI NIH HHS/ -- HL096113/HL/NHLBI NIH HHS/ -- R01 AG009521/AG/NIA NIH HHS/ -- R01 AG009521-24/AG/NIA NIH HHS/ -- R01 AG009521-25/AG/NIA NIH HHS/ -- R01 AG020961/AG/NIA NIH HHS/ -- R01 AG020961-06A2/AG/NIA NIH HHS/ -- R01 AG020961-07/AG/NIA NIH HHS/ -- R01 HL096113/HL/NHLBI NIH HHS/ -- R01 HL096113-03/HL/NHLBI NIH HHS/ -- T32 CA009151/CA/NCI NIH HHS/ -- England -- Nature. 2009 Nov 26;462(7272):433-41. doi: 10.1038/nature08602.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland. matthias.lutolf@epfl.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19940913" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biocompatible Materials/*therapeutic use ; Cell Communication ; *Cell Lineage/physiology ; Humans ; Regenerative Medicine/*methods ; Stem Cell Niche ; Stem Cells/*cytology/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2012-12-04
    Description: Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs) have a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPCs and that conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis. The rate of de novo lipid synthesis and subsequent proliferation of NSPCs is regulated by Spot14, a gene previously implicated in lipid metabolism, that we found to be selectively expressed in low proliferating adult NSPCs. Spot14 reduces the availability of malonyl-CoA, which is an essential substrate for Fasn to fuel lipogenesis. Thus, we identify here a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587167/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587167/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knobloch, Marlen -- Braun, Simon M G -- Zurkirchen, Luis -- von Schoultz, Carolin -- Zamboni, Nicola -- Arauzo-Bravo, Marcos J -- Kovacs, Werner J -- Karalay, Ozlem -- Suter, Ueli -- Machado, Raquel A C -- Roccio, Marta -- Lutolf, Matthias P -- Semenkovich, Clay F -- Jessberger, Sebastian -- P30 DK020579/DK/NIDDK NIH HHS/ -- R01 DK076729/DK/NIDDK NIH HHS/ -- R01 DK088083/DK/NIDDK NIH HHS/ -- England -- Nature. 2013 Jan 10;493(7431):226-30. doi: 10.1038/nature11689. Epub 2012 Dec 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23201681" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/cytology/*metabolism ; Animals ; Cell Proliferation ; Dentate Gyrus/metabolism ; Fatty Acid Synthases/deficiency/genetics/*metabolism ; Gene Expression Profiling ; Hippocampus/cytology/metabolism ; *Lipogenesis ; Malonyl Coenzyme A/metabolism ; Mice ; Mice, Transgenic ; Neural Stem Cells/cytology/*metabolism ; Neurogenesis ; Nuclear Proteins/genetics/metabolism ; Transcription Factors/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2012-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lutolf, Matthias P -- England -- Nature. 2012 Feb 22;482(7386):477-8. doi: 10.1038/482477a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22358833" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Culture Techniques ; Cellular Microenvironment/*radiation effects ; Extracellular Matrix/radiation effects ; Humans ; Hydrogels/chemistry/pharmacology/radiation effects ; *Light ; Regeneration/radiation effects ; Regenerative Medicine/methods ; Signal Transduction/radiation effects ; Stem Cells/cytology/drug effects ; Tissue Engineering/methods
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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