Publication Date:
2008-08-30
Description:
Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774752/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774752/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vijg, Jan -- Campisi, Judith -- P01 AG017242/AG/NIA NIH HHS/ -- P01 AG017242-060003/AG/NIA NIH HHS/ -- P01 AG017242-070003/AG/NIA NIH HHS/ -- P01 AG017242-080003/AG/NIA NIH HHS/ -- P01 AG017242-090003/AG/NIA NIH HHS/ -- P01 AG017242-100003/AG/NIA NIH HHS/ -- P30 AG025708-04/AG/NIA NIH HHS/ -- England -- Nature. 2008 Aug 28;454(7208):1065-71. doi: 10.1038/nature07216.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA. jvijg@aecom.yu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18756247" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/drug effects/genetics/*physiology
;
Animals
;
Biological Evolution
;
Disease
;
Humans
;
Life Expectancy/trends
;
Longevity/drug effects/genetics/*physiology
;
Phenotype
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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