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  • Springer  (67)
  • Nature Publishing Group  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Transport of K+ and other cations across phospholipid membranes by nonesterified fatty acids (1994)
    Springer
    The journal of membrane biology 141 (1994), S. 21-28 
    Details
    ISSN: 1432-1424
    Keywords: Fatty acids ; Liposomes ; Cation transport ; Membrane transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The rate of change of internal pH and transmembrane potential has been monitored in liposomes following the external addition of various cation salts. Oleic acid increases the transmembrane movement of H+ following the imposition of a K+ gradient. An initial fast change in internal pH is seen followed by a slower rate of alkalinization. High concentrations of the fatty acid enhance the rate comparable to that seen in the presence of nigericin in contrast to the effect of FCCP (carbonyl cyanide p-(tri-fluoromethoxy)phenyl hydrazone) which saturates at an intermediate value. The ability of nonesterified fatty acids to catalyze the movement of cations across the liposome membrane increases with the degree of unsaturation and decreases with increasing chain length. Li and Na salts cause a similar initial fast pH change but have less effect on the subsequent slower rate. Similarly, the main effect of divalent cation salts is on the initial fast change. The membrane potential can enhance or inhibit cation transport depending on its polarity with respect to the cation gradient. It is concluded that nonesterified fatty acids have the capability to complex with, and transport, a variety of cations across phospholipid bilayers. However, they do not act simply as proton/cation exchangers analogous to nigericin nor as protonophores analogous to FCCP. The full cycle of ionophoric action involves a combination of both functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232870
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  • 2
    Electronic Resource
    Electronic Resource
    Personality and theophylline pharmacokinetics (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 429-431 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; personality measures ; pharmacokinetics ; volunteers ; patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thirteen volunteers received an iv dose of theophylline followed by blood sampling for 8 h to calculate pharmacokinetic parameters. Ten patients with asthma undergoing chronic dosing with slow release aminophylline underwent 12 h of blood sampling to calculate theophylline clearance. Both groups completed an Eysenck Personality Inventory (EPI) from which was derived scores for neuroticism (N) and extroversion (E). Using multiple regression analysis no independent effect of either N or E score on theophylline clearance or half-life could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544362
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  • 3
    Electronic Resource
    Electronic Resource
    The disposition of inhaled lysine theophylline in volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543500
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  • 4
    Electronic Resource
    Electronic Resource
    The relationship between clearance of theophylline and age within the adult age range (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 177-179 
    Details
    ISSN: 1432-1041
    Keywords: theophylline clearance ; age ; adult age range ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547418
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  • 5
    Electronic Resource
    Electronic Resource
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 312-313 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A LETTER appeared in NATURE of Oct. 24, 1931, signed by Messrs. Leakey, Hopwood, and Reck, in which, among other conclusions, it is stated that “there is no possible doubt that the human skeleton came from Bed No. 2 and not from Bed No. 4”. This must be taken to mean that the skeleton is to be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/129312b0
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of Thyroxine on the Swelling of Mitochondria isolated from Various Tissues of the Rat (1956)
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 1119-1119 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Not all tissues respond in the same degree to the in vivo administration of thyroxine. Gordon and Heming8 found that the oxygen consumption of slices of liver, kidney, diaphragm and heart from thyrotoxic rats was significantly greater than normal, while that of slices of spleen, brain and testis ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1781119a0
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  • 7
    Electronic Resource
    Electronic Resource
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 903-903 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE are glad to find from Dr. Leakey's letter in NATURE of May 14 that he is in agreement with us in regarding the Oldoway skeleton as an artificial burial, and regret that, in common with everyone else whom we have consulted in this matter, we interpreted his original letter in NATURE of Oct. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/129903a0
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  • 8
    Electronic Resource
    Electronic Resource
    Misidentified cell (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 311-312 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR—Because the cell line TE671 is said to originate from an early culture of a human medulloblastoma1, it has been widely used to investigate this tumour type and as a model for primitive neural cells in general. And because the cell line can be infected by the AIDS virus HIV2 (in a way ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/337311c0
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  • 9
    Electronic Resource
    Electronic Resource
    Polymorphisms of the Vitamin D Receptor, Infant Growth, and Adult Bone Mass (1997)
    Springer
    Calcified tissue international 60 (1997), S. 233 -235 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone density — Vitamin D receptor — Polymorphism — Growth — Genetic.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Family and twin studies have demonstrated a strong genetic component to the development of peak bone mass. Early fetal and infant environment has also been shown to influence bone mass through an effect on skeletal size and mineral content. We report a retrospective study that has examined whether early infant growth is regulated by genetic factors shown to be associated with bone mass. We have determined the vitamin D receptor (VDR) gene alleles for 66 women (mean age 65.5 years) on whom detailed birth records were available. There was a statistically significant trend (P= 0.04) for VDR genotype against weight at the age of 1 year, with the ``tt'' homozygote group having 7% higher weight. We conclude that early fetal or infant environment may interact with an individual's underlying genotype to program early skeletal growth, and that this may track through later life to influence adult characteristics. Further prospective studies are required, however, to fully clarify the precise environmental and genetic mechanisms underlying these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900220
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  • 10
    Electronic Resource
    Electronic Resource
    The Relationship Between Childhood Growth, Bone Mass, and Muscle Strength in Male and Female Adolescents (1997)
    Springer
    Calcified tissue international 60 (1997), S. 405 -409 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone mineral density — Bone mineral content — Childhood growth — Dual X-ray absorptiometry — Muscle strength.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. In this population-based study, the relationship between childhood weight and height, and adolescent bone mass and muscle strength have been studied in 39 girls and 48 boys. Total body and femoral neck bone mass measurements (bone mineral content, BMC and bone mineral density, BMD) were made by dual X-ray absorptiometry. Quadriceps muscle strength was measured. Mean age at the time of measurement was 15.1 years for girls and boys. Results were individually linked to data on childhood (birth to 6 years of age) weight and height, taken from community health records. Childhood weight was found to be predictive of adolescent total body BMC (TBMC). However, this was not the case when correlating childhood weight and total body BMD (TBMD), suggesting that growth determines the size of the skeleton, whereas the density within that bone envelope is to a greater extent governed by other factors. Further, in a multiple regression model we found that the combined effect of childhood weight and height was significantly correlated with adolescent quadriceps muscle strength.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900253
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