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  • 1
    Electronic Resource
    Electronic Resource
    Sulphate aerosols and climate (1989)
    [s.l.] : Nature Publishing Group
    Nature 340 (1989), S. 438-438 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Schwartz1 proposes that because aerosol sulphate concentrations are consi-derably higher in the industrialized North-ern Hemisphere (NH) than in the Southern Hemisphere (SH), the climatic effect should be observed in the difference between the hemispheric temperature trends. Based on data ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/340438a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Smudging the fingerprints (1994)
    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 380-381 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IF scientific knowledge is loosely defined as 'understanding gained by the observation and classification of facts so as to be able to verify hypotheses', then scientific understanding of the climate effects of increasing greenhouse gases now depends on whether we can confirm projections of climate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/371380a0
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  • 3
    Electronic Resource
    Electronic Resource
    Trends in high-frequency climate variability in the twentieth century (1995)
    [s.l.] : Nature Publishing Group
    Nature 377 (1995), S. 217-220 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Changes in interannual and intraseasonal temperature vari-ability and the frequency distribution of precipitation were calcu-lated within several countries. Stations used included: a network of 187 well-distributed stations of the highest quality predomi-nantly from the USA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/377217a0
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  • 4
    Electronic Resource
    Electronic Resource
    Climate (communication arising) Impact of land-use change on climate (2004)
    [s.l.] : Nature Publishing Group
    Nature 427 (2004), S. 213-214 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Urbanization and other changes in land use have an impact on surface-air temperatures. Kalnay and Cai report that the observed surface-temperature trend in part of the United States exceeds the trend in the NCEP/NCAR 50-year reanalysis (NNR) and conclude that changes in land use account for the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/427213b
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  • 5
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    Jimena: efficient computing and system state identification for genetic regulatory networks (2013)
    BioMed Central
    Details
    Publication Date: 2013-10-13
    Description: Background: Boolean networks capture switching behavior of many naturally occurring regulatory networks. For semi-quantitative modeling, interpolation between ON and OFF states is necessary. The high degree polynomial interpolation of Boolean genetic regulatory networks (GRNs) in cellular processes such as apoptosis or proliferation allows for the modeling of a wider range of node interactions than continuous activator-inhibitor models, but suffers from scaling problems for networks which contain nodes with more than ~10 inputs. Many GRNs from literature or new gene expression experiments exceed those limitations and a new approach was developed. Results: (i) As a part of our new GRN simulation framework Jimena we introduce and setup Boolean-tree-based data structures; (ii) corresponding algorithms greatly expedite the calculation of the polynomial interpolation in almost all cases, thereby expanding the range of networks which can be simulated by this model in reasonable time. (iii) Stable states for discrete models are efficiently counted and identified using binary decision diagrams. As application example, we show how system states can now be sampled efficiently in small up to large scale hormone disease networks (Arabidopsis thaliana development and immunity, pathogen Pseudomonas syringae and modulation by cytokinins and plant hormones). Conclusions: Jimena simulates currently available GRNs about 10-100 times faster than the previous implementation of the polynomial interpolation model and even greater gains are achieved for large scale-free networks. This speed-up also facilitates a much more thorough sampling of continuous state spaces which may lead to the identification of new stable states. Mutants of large networks can be constructed and analyzed very quickly enabling new insights into network robustness and behavior.
    Electronic ISSN: 1471-2105
    Topics: Biology , Computer Science
    Published by BioMed Central
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