Publication Date:
2011-08-24
Description:
Lipid accumulation in organs is strongly associated with insulin resistance. However, the causal relationship is uncertain. For hepatic steatosis, this relationship has given rise to many studies and theories. One hypothesis, suggested as unifying (1), posits simply that accumulation of diacylglycerol induces hepatic insulin resistance by interfering with insulin signaling.We previously tested the relationship between hepatic steatosis and insulin resistance by generating transgenic mice that overexpress triacylglycerol (TG) synthesis enzymes [acyl-CoA:diacylglcyerol acyltransferases (DGATs)] in the liver (2). Analysis of two lines that overexpressed DGAT2 (low- and high-expressors) refuted the DG hypothesis: hepatic DG accumulation (and other lipids such as TG,...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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